| 高凌雲,王百志,王小龙,宋海滨,孟 君.急性失代偿性心力衰竭患者血清CST、CyPA、MSTN表达及其临床意义[J].,2023,(21):4163-4167 |
| 急性失代偿性心力衰竭患者血清CST、CyPA、MSTN表达及其临床意义 |
| Expression and Its Clinical Significance of Serum CST, CyPA and MSTN in Patients with Acute Decompensated Heart Failure |
| 投稿时间：2023-04-08 修订日期：2023-04-30 |
| DOI：10.13241/j.cnki.pmb.2023.21.031 |
| 中文关键词: 急性失代偿性心力衰竭 CST CyPA MSTN 预后 |
| 英文关键词: Acute decompensated heart failure CST CyPA MSTN Prognosis |
| 基金项目:山东省医药卫生科技计划项目（2016WS0668） |
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| 中文摘要: |
| 摘要 目的：探讨急性失代偿性心力衰竭（ADHF）患者血清儿茶酚抑素（CST）、亲环素A（CyPA）、肌肉生长抑制素（MSTN）的表达及其临床意义。方法：选取2021年4月～2022年4月潍坊市人民医院收治的100例ADHF患者为ADHF组，根据预后情况将其分为预后不良组(32例)和预后良好组（68例），另选取50名健康体检志愿者为对照组。采用酶联免疫吸附法检测血清CST、CyPA、MSTN表达。采用多因素Logistic回归分析ADHF患者预后不良的因素，采用受试者工作特征（ROC）曲线分析血清CST、CyPA、MSTN表达对ADHF患者预后不良的评估价值。结果：ADHF组血清CST、CyPA、MSTN表达高于对照组（P＜0.05）。100例ADHF患者预后不良发生率为32.00%。多因素Logistic回归分析显示，纽约心脏协会（NYHA）心功能分级≥Ⅲ级、N末端前体B型钠尿肽（NT-proBNP）、CST、CyPA、MSTN升高为ADHF患者预后不良的独立危险因素，左室射血分数（LVEF）升高为独立保护因素（P＜0.05）。ROC曲线分析显示，血清CST、CyPA、MSTN表达联合评估ADHF患者预后不良的曲线下面积（AUC）大于CST、CyPA、MSTN表达单独评估。结论：血清CST、CyPA、MSTN高表达与ADHF患者预后不良有关，联合血清CST、CyPA、MSTN表达评估ADHF患者预后不良的价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression and its clinical significance of serum catestatin (CST), cyclophilin A (CyPA) and myostatin (MSTN) in patients with acute decompensated heart failure (ADHF). Methods: 100 patients with ADHF who were admitted to Weifang People's Hospital from April 2021 to April 2022 were selected as ADHF group, and they were divided into poor prognosis group（n=32） and good prognosis group(n=68) according to the prognosis, another 50 healthy examination volunteers were selected as control group. Serum CST, CyPA and MSTN expressions were detected by enzyme-linked immunosorbent assay. Multivariate Logistic regression was used to analyze the factors of poor prognosis in patients with ADHF, and receiver operating characteristic (ROC) curve was used to analyze the evaluation value of serum CST, CyPA and MSTN expression on poor prognosis in patients with ADHF. Results: The serum CST, CyPA and MSTN expressions in the ADHF group were higher than those in the control group (P＜0.05). The incidence of poor prognosis in 100 patients with ADHF was 32.00%. Multivariate Logistic regression analysis showed that New York Heart Association (NYHA) cardiac function grade ≥grade Ⅲ, elevated N-terminal precursor B-type natriuretic peptide (NT-proBNP), CST, CyPA and MSTN were independent risk factors for poor prognosis in patients with ADHF. Elevated left ventricular ejection fraction (LVEF) was an independent protective factor (P＜0.05). ROC curve analysis showed that the area under curve (AUC) of combined serum CST, CyPA and MSTN expression in the assessment of poor prognosis of patients with ADHF was greater than that of CST, CyPA and MSTN expression alone evaluation. Conclusion: The serum CST, CyPA and MSTN high expression are associated with poor prognosis in patients with ADHF, the combined serum CST, CyPA and MSTN expression has of high value in evaluating poor prognosis in patients with ADHF. |
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