| 林卫佳,袁胜芳,李 峰,于亚楠,刘 洋,邓梅毓,苏 菁,项保利,张志华.复方苦参注射液腔内灌注治疗对恶性胸腔积液患者机体免疫功能及肿瘤标志物水平的影响[J].,2023,(19):3758-3762 |
| 复方苦参注射液腔内灌注治疗对恶性胸腔积液患者机体免疫功能及肿瘤标志物水平的影响 |
| Effect of Intracavitary Perfusion of Compound Sophora Flavescens Injection on the Immune Function and Tumor Markers in Patients with Malignant Pleural Effusion |
| 投稿时间：2023-03-23 修订日期：2023-04-18 |
| DOI：10.13241/j.cnki.pmb.2023.19.032 |
| 中文关键词: 恶性胸腔积液 复方苦参注射液 疗效 免疫功能 肿瘤标志物 |
| 英文关键词: Malignant pleural effusion Compound Sophora flavescens injection Curative effect Immune function Tumor marker |
| 基金项目:河北省医学科学研究课题计划项目（20200525）；河北省张家口市重点研发计划项目（2021046D） |
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| 中文摘要: |
| 摘要 目的：探讨复方苦参注射液腔内灌注治疗对恶性胸腔积液患者机体免疫功能及肿瘤标志物水平的影响。方法：选取河北北方学院附属第一医院2020年12月到2022年12月期间收治的52例恶性胸腔积液患者，将每位患者随机进行编号，获得1～52个编号，按照奇偶法将患者分为对照组（n=26）和观察组（n=26）。对照组采用顺铂腔内灌注治疗，观察组在对照组的基础上联用复方苦参注射液腔内灌注治疗，比较两组患者的治疗效果、T淋巴细胞亚群（CD3+、CD4+、CD4+/CD8+）、癌胚抗原（CEA）、糖类抗原125（CA125）、生活质量改善率以及毒副反应。结果：观察组治疗总有效率73.08%高于对照组的42.31%（P＜0.05）。治疗后观察组的CD3+、CD4+、CD4+/CD8+与治疗前比较明显升高，且高于对照组（P<0.05）。治疗后两组患者的血清CEA、CA125水平与治疗前比较均明显降低，且观察组低于对照组（P<0.05）。观察组生活质量改善率76.92%高于对照组46.15%（P<0.05）。观察组的骨髓抑制、胃肠道反应明显轻于对照组（P<0.05）。结论：复方苦参注射液腔内灌注治疗对恶性胸腔积液患者具有较好的疗效，且可以改善患者机体免疫功能及生活质量，降低血清肿瘤标志物水平和毒副反应。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of intracavitary perfusion of compound Sophora flavescens injection on the immune function and the levels of tumor markers in patients with malignant pleural effusion. Methods: 52 patients with malignant pleural effusionwho were treated in The First Affiliated Hospital of Hebei North University from December 2020 to December 2022 were selected. Each patient was randomly numbered to obtain 1-52 numbers, and were divided into control group (n=26) and observation group (n=26) according to the parity method. The control group were treated with cisplatin by intracavitary perfusion, the observation group were treated with compound Sophora flavescens injection by intracavitary perfusion on the basis of the control group. The treatment effect, T lymphocyte subsets (CD3+, CD4+, CD4+/CD8+), carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), quality of life improvement rate and toxic and side effects were compared between the two groups. Results: The total effective rate of treatment in the observation group was 73.08% higher than 42.31% in the control group(P<0.05). After treatment, the CD3+, CD4+ and CD4+/CD8+ in the observation group were higher than those before treatment, and higher than those in the control group(P<0.05). After treatment, the levels of serum CEA and CA125 in the two groups were significantly lower than those before treatment, and the observation group were lower than that of the control group(P<0.05). The improvement rate of quality of life in the observation group was 76.92% higher than that 46.15% in the control group(P<0.05). The myelosuppression and gastrointestinal reaction in the observation group were significantly lighter than that of the control group (P<0.05). Conclusion: Intracavitary perfusion of compound Sophora flavescens injection has a good effect on patients with malignant pleural effusion, and it can improve immune function and quality of life, reduce serum the levels of tumor markers and toxic and side effects. |
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