| 戴沛军,蒲中枢,周新人,云升皓,魏 嘉.肝爽颗粒联合替诺福韦酯对慢性乙型肝炎患者肝纤维化标志物和外周血单个核细胞Nrf2 /HO-1信号通路的影响[J].,2023,(19):3651-3654 |
| 肝爽颗粒联合替诺福韦酯对慢性乙型肝炎患者肝纤维化标志物和外周血单个核细胞Nrf2 /HO-1信号通路的影响 |
| Effects of Ganshuang Granules Combined with Tenofovir Dipivoxil on Hepatic Fibrosis Markers and Nrf2/HO-1 Signaling Pathway of Peripheral Blood Mononuclear Cells of Patients with Chronic Hepatitis B |
| 投稿时间：2023-03-04 修订日期：2023-03-28 |
| DOI：10.13241/j.cnki.pmb.2023.19.010 |
| 中文关键词: 肝爽颗粒 替诺福韦酯 慢性乙型肝炎 肝纤维化 Nrf2/HO-1信号通路 |
| 英文关键词: Ganshuang granules Tenofovir dipivoxil Chronic hepatitis B Hepatic fibrosis Nrf2/HO-1 signaling pathway |
| 基金项目:甘肃省科技计划项目（21JR7RA017） |
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| 中文摘要: |
| 摘要 目的：观察肝爽颗粒联合替诺福韦酯对慢性乙型肝炎（CHB）患者肝纤维化标志物和外周血单个核细胞核因子E2相关因子2（Nrf2）/血红素氧合酶 1（HO-1）信号通路的影响。方法：选择中国人民解放军联勤保障部队第九四〇医院自2020年5月-2022年5月期间收治的80例CHB患者，按照随机数字表法分为对照组（n=40，替诺福韦酯治疗）和观察组（n=40，肝爽颗粒联合替诺福韦酯治疗）。对比两组乙型肝炎病毒（HBV）-脱氧核糖核酸（DNA）转阴率、肝纤维化指标、外周血单个核细胞Nrf2/HO-1信号通路相关指标、肝功能指标、乙型肝炎e抗原（HBeAg）转阴率、不良反应发生率。结果：观察组的HBV-DNA转阴率和HBeAg转阴率均高于对照组（P<0.05）。与对照组相比，观察组治疗3个月后总胆红素（TBIL）、层黏连蛋白（LN）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、Ⅲ型前胶原（PcⅢ）、透明质酸（HA）、Ⅳ型胶原（IV-C）更低，Nrf2 mRNA、HO-1 mRNA更高（P<0.05）。两组不良反应发生率比较无差异（P>0.05）。结论：CHB患者采用肝爽颗粒联合替诺福韦酯治疗，可促进肝功能和肝纤维化标志物水平改善，调节外周血单个核细胞Nrf2/HO-1信号通路。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of Ganshuang granules combined with tenofovir dipivoxil on hepatic fibrosis markers and nuclear factor E2 related factor 2 (Nrf2)/haem oxygenase 1 (HO-1) signaling pathway of peripheral blood mononuclear cells of patients with chronic hepatitis B (CHB). Methods: 80 patients with CHB who were admitted to the 940 Hospital of Joint Logistics Support Force of Chinese People's Liberation Army from May 2020 to May 2022 were selected, and they were divided into control group (n=40, treated with tenofovir dipivoxil) and observation group (n=40, treated with Ganshuang granules combined with tenofovir dipivoxil) according to the random number table method. The hepatitis B virus (HBV) - deoxyribonucleic acid (DNA) negative conversion rate, hepatic fibrosis indexes, relevant indexes of Nrf2/HO-1 signaling pathway of peripheral blood mononuclear cells, hepatic function indexes, hepatitis B e antigen (HBeAg) negative conversion rate, and adverse reaction rate were compared between the two groups. Results: The HBV-DNA negative conversion rate and HBeAg negative conversion rate of the observation group were higher than those of the control group (P<0.05). Compared with the control group, the total bilirubin (TBIL), laminin (LN), alanine aminotransferase (ALT), aspartate aminotransferase (AST), type III procollagen (PcIII), hyaluronic acid (HA), type IV collagen (IV-C) were lower, and the Nrf2 mRNA and HO-1 mRNA were higher of the observation group at 3 months after treatment(P<0.05). There was no difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Patients with CHB are treated with Ganshuang granules combined with tenofovir dipivoxil, which can promote the improvement of hepatic function and hepatic fibrosis markers levels, regulates Nrf2/HO-1 signaling pathway. |
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