| 英 华,王庆红,吴桂花,吴 群,赵颖辉.超声造影联合血清HE4、CA125、TK1、TAP对子宫内膜恶性病变的诊断价值研究[J].,2023,(16):3173-3177 |
| 超声造影联合血清HE4、CA125、TK1、TAP对子宫内膜恶性病变的诊断价值研究 |
| Study on the Diagnostic Value of Contrast Enhanced Ultrasound Combined with Serum HE4, CA125, TK1 and TAP in Endometrial Malignant Lesions |
| 投稿时间：2023-01-28 修订日期：2023-02-22 |
| DOI：10.13241/j.cnki.pmb.2023.16.034 |
| 中文关键词: 子宫内膜恶性病变 超声造影 HE4 CA125 TK1 TAP 诊断价值 |
| 英文关键词: Endometrial malignant lesions Contrast enhanced ultrasound HE4 CA125 TK1 TAP Diagnostic value |
| 基金项目:山东省教育厅科技创新项目（J08LG20） |
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| 中文摘要: |
| 摘要 目的：探讨超声造影联合血清人附睾分泌蛋白4（HE4）、糖类抗原125（CA125）、胸苷激酶1（TK1）、肿瘤异常蛋白（TAP）对子宫内膜恶性病变的诊断价值。方法：选择2019年1月至2022年1月于济南市人民医院超声科行超声造影检查的95例子宫内膜病变患者。检测其血清HE4、CA125、TK1、TAP水平，通过超声造影检查获得造影参数开始增强时间、达峰时间、峰值强度、梯度、TIC曲线下面积（TIC-AUC）。受试者工作特征（ROC）曲线分析超声造影参数联合血清HE4、CA125、TK1、TAP诊断子宫内膜恶性病变的价值。结果：根据病理结果将患者分为恶性组（37例）和良性组（58例），恶性组峰值强度、TIC-AUC、血清HE4、CA125、TK1、TAP水平高于良性组（P＜0.05），恶性组开始增强时间、达峰时间、梯度与良性组比较差异无统计学意义（P＞0.05）。峰值强度、TIC-AUC、HE4、CA125、TK1、TAP 单独诊断子宫内膜恶性病变的曲线下面积为0.767、0.676、0.656、0.691、0.713、0.721，联合诊断子宫内膜恶性病变的曲线下面积为0.896，高于单独指标诊断。结论：超声造影参数峰值强度、TIC-AUC联合血清HE4、CA125、TK1、TAP诊断子宫内膜恶性病变具有较高的价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the diagnostic value of contrast enhanced ultrasound combined with serum human epididymal secreted protein 4 (HE4), carbohydrate antigen 125 (CA125), thymidine kinase 1 (TK1) and tumor abnormal protein (TAP) in endometrial malignant lesions. Methods: From January 2019 to January 2022, 95 patients with endometrial lesions who underwent contrast enhanced ultrasound examination in the Ultrasound Department of the Jinan People's Hospital were selected.The levels of serum HE4, CA125, TK1 and TAP were detected. The starting enhancement time, peak time, peak intensity, gradient and area under the TIC curve (TIC-AUC) of the contrast parameters were obtained through contrast enhanced ultrasound examination. The value of contrast enhanced ultrasound parameters combined with serum HE4, CA125, TK1, TAP in diagnosis endometrial malignant lesions was analyzed by receiver operating characteristic (ROC) curve. Results: According to the pathological results,the patients were divided into malignant group (37 cases) and benign group (58 cases). The peak intensity, TIC-AUC, the levels of serum HE4, CA125, TK1 and TAP in the malignant group were higher than those in the benign group (P＜0.05), there were no significant differences in the beginning enhancement time, peak time and gradient between malignant group and benign group(P>0.05). The area under curve for differential diagnosis of endometrial malignant lesions with peak intensity, TIC-AUC, HE4, CA125, TK1 and TAP was 0.767, 0.676, 0.656, 0.691, 0.713 and 0.721, and the area under curve for diagnosis of endometrial malignant lesions with combined peak intensity, TIC-AUC, HE4, CA125, TK1 and TAP was 0.896, which was higher than that of differential diagnosis with single index. Conclusion: The combination of peak intensity of contrast enhanced ultrasound parameters, TIC-AUC and serum HE4, CA125, TK1, TAP has high value in diagnosis benign and malignant endometrial lesions. |
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