| 张晓鸣,刘彦茹,李斌彬,贾 强,刘华清,王志仁.血清连蛋白、高迁移率族蛋白B1水平与双相障碍患者认知功能和肠道菌群相对丰度的相关性分析[J].,2023,(14):2796-2800 |
| 血清连蛋白、高迁移率族蛋白B1水平与双相障碍患者认知功能和肠道菌群相对丰度的相关性分析 |
| Correlation Analysis between Serum Catenin and High Mobility Group Box 1 Levels and Cognitive Function and the Relative Abundance of Intestinal Flora in Patients with Bipolar Disorder |
| 投稿时间：2023-02-23 修订日期：2023-03-18 |
| DOI：10.13241/j.cnki.pmb.2023.14.038 |
| 中文关键词: 双相障碍 连蛋白 高迁移率族蛋白B1 认知功能 肠道菌群相对丰度 相关性 |
| 英文关键词: Bipolar disorder Catenin High mobility group box 1 Cognitive function Relative abundance of intestinal flora Correlation |
| 基金项目:首都卫生发展科研专项项目（2022-2-2133）；北京市医院管理局临床医学发展专项经费资助（XMLX202130） |
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| 中文摘要: |
| 摘要 目的：探讨血清连蛋白、高迁移率族蛋白B1（HMGB1）水平与双相障碍患者认知功能和肠道菌群相对丰度的相关性。方法：选取2018年5月～2021年5月北京回龙观医院收治的80例双相障碍患者，其中狂躁发作43例，抑郁发作37例，分别作为狂躁组、抑郁组，取同期于我院体检的健康志愿者62例作为对照组。比较三组血清连蛋白、HMGB1水平，并采用重复性成套神经心理状态测验（RBANS）评估三组认知功能。收集受试者的粪便标本，经聚合酶链反应（PCR）与测序技术分析肠道菌群相对丰度。利用Pearson线性相关检验分析血清连蛋白、HMGB1水平与RBANS评分及肠道菌群相对丰度的相关性。结果：狂躁组、抑郁组血清连蛋白、HMGB1水平高于对照组，即刻记忆、言语功能、注意、延时记忆、视觉广度评分及RBANS总分均低于对照组（P＜0.05）。狂躁组、抑郁组拟杆菌纲、拟杆菌目相对丰度均低于对照组，大肠埃希菌种相对丰度高于对照组，且狂躁组青春双歧杆菌相对丰度高于对照组、抑郁组，抑郁组青春双歧杆菌相对丰度低于对照组，抑郁组毛螺菌属相对丰度高于狂躁组与对照组（P＜0.05）。血清连蛋白与拟杆菌纲、拟杆菌目呈负相关，与大肠埃希菌种呈正相关（P＜0.05），但与RBANS总分无相关性（P＞0.05）。血清HMGB1与RBANS总分、拟杆菌纲、拟杆菌目呈负相关，与大肠埃希菌种呈正相关（P＜0.05）。结论：双相障碍患者的血清连蛋白、HMGB1水平增高，其中连蛋白与患者认知功能异常无明显关联，而HMGB1与认知功能异常有关，且二者均会影响患者的肠道菌群变化。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between the serum catenin, high mobility group box 1 (HMGB1) levels and cognitive function and the relative abundance of intestinal flora in patients with bipolar disorder. Methods: 80 patients with bipolar disorder who were treated in Beijing Huilongguan Hospital from May 2018 to May 2021 were selected, including 43 cases of manic attack, and 37 cases of depressive attack, respectively as the manic group and the depression group, 62 healthy volunteers who underwent physical examination in our hospital at the same time were taken as the control group. The serum catenin and HMGB1 levels in the three groups were compared. The cognitive function of the three groups was evaluated by Repeatable Battery for the Assessment of Neuropsychologicals Status (RBANS). Fecal samples were collected, and the relative abundance of intestinal flora was analyzed by Polymerase Chain Reaction (PCR) and sequencing. Pearson linear correlation test was used to analyze the correlation between the levels of serum catenin and HMGB1 and RBANS score and the relative abundance of intestinal flora. Results: The serum catenin and HMGB1 levels in the manic group and depression group were higher than those in the control group, and the scores of immediate memory, speech function, attention, delayed memory, visual span and RBANS total score were lower than those in the control group (P<0.05). The relative abundance of Bacteroidia and Bacteroidales in the manic group and depression group were lower than those in the control group, the relative abundance of Escherichia coli was higher than that in the control group, and the relative abundance of Bifidobacterium adolescens in the manic group was higher than that in the control group and depression group. The relative abundance of Bifidobacterium adolescens in the depression group was lower than that in the control group, and the relative abundance of Spirillum in the depression group was higher than that in the manic group and control group(P<0.05). Serum catenin was negatively correlated with Bacteroidia and Bacteroidales, and positively correlated with Escherichia coli (P<0.05), but it has no correlation with the total score of RBANS(P>0.05). Serum HMGB1 was negatively correlated with the RBANS total score, Bacteroidia and Bacteroidales, and positively correlated with Escherichia coli (P<0.05). Conclusion: The serum catenin and HMGB1 levels in patients with bipolar disorder are increased. There is no significant correlation between catenin and cognitive dysfunction, but HMGB1 is related to cognitive dysfunction, and both of them would affect the changes of intestinal flora. |
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