| 王冰心,曹海育,李建英,孙 静,杨 培.奥洛他定联合金蝉止痒颗粒治疗对湿疹患者皮肤损伤、皮肤屏障功能及炎症因子的影响[J].,2023,(13):2591-2595 |
| 奥洛他定联合金蝉止痒颗粒治疗对湿疹患者皮肤损伤、皮肤屏障功能及炎症因子的影响 |
| Effect of Olotadine Combined with Jinchan Zhiyang Granules on Skin Damage, Skin Barrier Function and Inflammatory Factors in Patients with Eczema |
| 投稿时间：2023-01-28 修订日期：2023-02-27 |
| DOI：10.13241/j.cnki.pmb.2023.13.039 |
| 中文关键词: 蝉止痒颗粒 湿疹 皮肤损伤 皮肤屏障功能 炎症因子 |
| 英文关键词: Cicada antipruritic granules Eczema Skin damage Skin barrier function Inflammatory factors |
| 基金项目:2018年河北省卫健委重点科技研究计划项目（20181009） |
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| 中文摘要: |
| 摘要 目的：探究金蝉止痒颗粒辅助治疗对湿疹患者皮肤损伤、皮肤屏障功能及炎症因子的影响。方法：选取2020年6月~2022年5月来我院皮肤科就诊治疗的120例慢性湿疹的患者，按照治疗方式的不同分为对照组（n=60）与观察组（n=60），其中对照组口服奥洛他定治疗，观察组在对照治疗基础之上加服金蝉止痒颗粒。对比两组患者治疗后的临床疗效、湿疹皮肤损伤严重程度评分皮肤屏障功能和炎性因子水平的变化。记录并比较两组患者的不良反应发生情况。结果：观察组总有效率（95.00%）显著高于对照组总有效率（60.00%），差异有统计学意义（P<0.05）。治疗后与治疗前相比，两组患者瘙痒评分、皮损面积评分及EASI评分均显著下降，且观察组各项指标优于对照组，有统计学意义（P<0.05）。两组患者TEWL指标显著降低，而WCSC和SC指标显著升高，且观察组上述指标显著优于对照组，差异均有统计学意义（P<0.05）。两组患者血清IL-2水平明显升高，而IL-4、TNF-α水平显著降低，且观察组较对照组变化更为明显，差异均有统计学意义（P<0.05）。对照组患者的不良反应发生率为5.00%，治疗组为3.33%，两组比较无统计学意义（P>0.05）。结论：奥洛他定联合金蝉止痒颗粒治疗湿疹能够减少皮肤损伤，修复湿疹患者皮肤屏障损伤，调节血清炎症因子的变化，改善湿疹患者临床症状。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Jinchan Zhiyang Granule on skin damage, skin barrier function and inflammatory factors in patients with eczema. Methods: 120 patients with chronic eczema who came to the dermatology department of our hospital from June 2020 to May 2022 were selected and divided into the control group (n=60) and the observation group (n=60) according to the different treatment methods. The control group was treated by oral administration of olatadine, and the observation group was treated by Jinchan Zhiyang Granule on the basis of the control treatment The clinical efficacy, skin barrier function and inflammatory factor level of eczema skin damage severity score were compared between the two groups after treatment. The adverse reactions of the two groups were recorded and compared. Results: The total effective rate of the observation group(95.00%) was significantly higher than that of the control group (60.00%), the difference was statistically significant(P<0.05). After treatment, compared with before treatment, the itching score, lesion area score and EASI score of patients in both groups decreased significantly, and all indicators in the observation group were better than those in the control group, with statistical significance (P<0.05). TEWL index of the two groups decreased significantly, while WCSC and SC index increased significantly, and the above indexes of the observation group were significantly better than those of the control group, the difference was statistically significant(P<0.05). The level of serum IL-2 was significantly increased in the two groups, while IL-4 and TNF-α The level was significantly reduced, and the change in the observation group was more obvious than that in the control group, the difference was statistically significant(P<0.05). The incidence of adverse reactions in the control group was 5.00%, while that in the treatment group was 3.33%. There was no significant difference between the two groups(P>0.05). Conclusion: Olotadine combined with Jinchan Zhiyang Granules can reduce the skin damage, repair the skin barrier damage, regulate the changes of serum inflammatory factors, and improve the clinical symptoms of patients with eczema. |
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