| 周芳怡,孙 莉,单建学,吴 进,凌 超,瞿 慧,成碧薇.金英胶囊联合阿奇霉素对慢性盆腔炎患者盆腔血流动力学、炎症细胞因子和T淋巴细胞亚群的影响[J].,2023,(13):2578-2581 |
| 金英胶囊联合阿奇霉素对慢性盆腔炎患者盆腔血流动力学、炎症细胞因子和T淋巴细胞亚群的影响 |
| Effects of Jinying Capsule Combined with Azithromycin on Pelvic Hemodynamics, Inflammatory Cytokines and T Lymphocyte Subsets in Patients with Chronic Pelvic Inflammatory Disease |
| 投稿时间：2023-01-03 修订日期：2023-01-26 |
| DOI：10.13241/j.cnki.pmb.2023.13.036 |
| 中文关键词: 金英胶囊 阿奇霉素 慢性盆腔炎 盆腔血流动力学 炎症细胞因子 T淋巴细胞亚群 |
| 英文关键词: Jinying capsule Azithromycin Chronic pelvic inflammatory disease Pelvic hemodynamics Inflammatory cytokines T lymphocyte subsets |
| 基金项目:湖南省卫生健康委科研计划项目（20200786） |
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| 中文摘要: |
| 摘要 目的：观察金英胶囊联合阿奇霉素对慢性盆腔炎患者盆腔血流动力学、炎症细胞因子和外周血T淋巴细胞亚群的影响。方法：按照随机数字表法，将2020年3月~2022年9月期间湖南省妇幼保健院收治的147例慢性盆腔炎患者分为对照组（阿奇霉素片治疗，73例）和研究组（金英胶囊联合阿奇霉素片治疗，74例）。对比两组临床指标、盆腔血流动力学、炎症细胞因子和外周血T淋巴细胞亚群水平，同时观察两组不良反应发生情况。结果：与对照组相比，研究组乏力、腰骶疼痛、白带量多等症状缓解时间更短（P<0.05）。与对照组相比，研究组治疗后白细胞介素-10（IL-10）更高，白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）更低（P<0.05）。与对照组相比，研究组治疗后CD8+更低，CD3+、CD4+、CD4++/CD8+更高（P<0.05）。与对照组相比，研究组治疗后卵巢动脉、子宫动脉的阻力指数（RI）更低，卵巢动脉、子宫动脉的脉搏指数（PI）、收缩期峰值流速（PSV）更高（P<0.05）。两组不良反应发生率组间比较无差异（P>0.05）。结论：金英胶囊联合阿奇霉素治疗慢性盆腔炎患者，可促进临床症状改善，可能与改善患者的盆腔血流动力学、炎症细胞因子和外周血T淋巴细胞亚群水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of Jinying capsule combined with azithromycin on pelvic hemodynamics, inflammatory cytokines and peripheral blood T lymphocyte subsets in patients with chronic pelvic inflammatory disease. Methods: According to the method of random number table, 147 patients with chronic pelvic inflammatory disease who were admitted to Hunan Maternal and Child Health Hospital from March 2020 to September 2022 were divided into control group (treated with azithromycin tablets, 73 cases) and study group (treated with Jinying capsule combined with azithromycin tablets, 74 cases). The clinical indexes, pelvic hemodynamics, inflammatory cytokines and peripheral blood T lymphocyte subsets in the two groups were compared, and the occurrence of adverse reactions in the two groups was also observed. Results: Compared with the control group, the relief time of fatigue, lumbosacral pain, high leucorrhea and other symptoms in the study group were shorter (P<0.05). Compared with the control group, the interleukin-10 (IL-10) in the study group after treatment was higher, and the interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) were lower (P<0.05). Compared with the control group, CD8+ in the study group after treatment was lower, and CD3+, CD4+ and CD4+/CD8+ were higher (P<0.05). Compared with the control group, the resistance index (RI) of ovarian artery and uterine artery in the study group after treatment were lower, and the pulse index(PI) and peak systolic flow velocity(PSV) of ovarian artery and uterine artery were higher (P<0.05). There was no difference in the incidence of adverse reactions in the two groups(P>0.05). Conclusion: Jinying capsule combined with azithromycin in the treatment of patients with chronic pelvic inflammatory disease can promote the improvement of clinical symptoms, which may be related to the improvement of pelvic hemodynamics, inflammatory cytokines and peripheral blood T lymphocyte subsets levels. |
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