| 瞿 慧,张 霞,梁朝明,石小青,葛 静.血清TSPO、Nesfatin-1、AngⅡ与产后抑郁症的关系分析及其预测价值研究[J].,2023,(12):2387-2391 |
| 血清TSPO、Nesfatin-1、AngⅡ与产后抑郁症的关系分析及其预测价值研究 |
| Analysis of Relationship between Serum TSPO, Nesfatin-1, AngⅡ and Postpartum Depression and Their Predictive Value Study |
| 投稿时间：2023-02-04 修订日期：2023-02-25 |
| DOI：10.13241/j.cnki.pmb.2023.12.035 |
| 中文关键词: TSPO Nesfatin-1 AngⅡ 产后抑郁症 预测价值 |
| 英文关键词: TSPO Nesfatin-1 AngⅡ Postpartum depression Predictive value |
| 基金项目:湖南省自然科学基金项目（2019JJ80040） |
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| 中文摘要: |
| 摘要 目的：探讨血清18 kDa 转位蛋白（TSPO）、摄食抑制因子1（Nesfatin-1）、血管紧张素Ⅱ（AngⅡ）与产后抑郁症（PPD）的关系，并分析其预测PPD的价值。方法：选择2020年2月至2022年6月湖南省妇幼保健院收治的187例产妇，产后3周根据爱丁堡产后抑郁量表（EPDS）评分结果将产妇分为抑郁组（≥13分，31例）和无抑郁组（＜12分，156例）。检测产前、产后3 d血清TSPO、Nesfatin-1、AngⅡ水平，单因素和多因素Logistic回归分析PPD的影响因素，受试者工作特征曲线（ROC）分析TSPO、Nesfatin-1、AngⅡ预测PPD的价值。结果：抑郁组产后血清TSPO水平降低，且低于无抑郁组（P＜0.05），血清Nesfatin-1、AngⅡ水平增高，且高于无抑郁组（P＜0.05）。单因素分析显示，抑郁组文化程度高中及以下、夫妻关系紧张、家庭经济收入＜5000元/月、分娩方式为剖宫产比例高于无抑郁组（P＜0.05），新生儿Apgar评分低于无抑郁组（P＜0.05）。多因素Logistic回归分析结果显示低新生儿Apgar评分、文化程度高中及以下、高Nesfatin-1、高AngⅡ、低TSPO是PPD的危险因素（P＜0.05）。TSPO、Nesfatin-1、AngⅡ预测PPD的曲线下面积为0.722、0.736、0.700，联合TSPO、Nesfatin-1、AngⅡ预测PPD的曲线下面积为0.901，高于单独预测。结论：PPD患者血清TSPO水平降低，Nesfatin-1、AngⅡ水平增高，且与PPD的发生有关，联合TSPO、Nesfatin-1、AngⅡ在PPD发生风险的预测方面具有较高价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum 18 kDa translocation protein (TSPO), Nesfatin-1 (Nesfatin-1), angiotensin Ⅱ (AngⅡ) and postpartum depression (PPD), and to analyze their value in predicting PPD. Methods: 187 parturients who were admitted to Hunan Maternal and Child Health Hospital from February 2020 to June 2022 were selected. According to the Edinburgh Postpartum Depression Scale (EPDS), the parturients were divided into depression group (≥13 scores, 31 cases) and non-depression group (<12 scores, 156 cases)in 3 weeks after delivery. Serum levels of TSPO, Nesfatin-1 and AngⅡwere detected 3d before and after delivery. Univariate and multivariate Logistic regression were used to analyze the influencing factors of PPD. Receiver operating characteristic curve (ROC) was used to analyze the value of TSPO, Nesfatin-1 and AngⅡ in predicting PPD. Results: The level of postpartum serum TSPO in the depression group decreased, and was lower than that in the non-depression group (P＜0.05), and the levels of serum Nesfatin-1 and AngⅡincreased, and were higher than those in the non-depression group (P＜0.05). Univariate analysis showed that the proportion of education level high school or below, conjugal relation tension, family economic income < 5000 yuan/month, cesarean section delivery in the depression group were higher than those in the non-depression group (P＜0.05), and the Apgar score of newborn was lower than that in the non-depression group (P＜0.05). Multivariate Logistic regression analysis showed that low Apgar score of newborn, education level high school or below, high Nesfatin-1, high AngⅡ and low TSPO were risk factors for PPD (P＜0.05). The area under the curve predicted by TSPO, Nesfatin-1 and AngⅡ were 0.722, 0.736 and 0.700. Combined with TSPO, Nesfatin-1 and AngⅡ, the area under the curve of PPD was 0.901, which was higher than that predicted by individual indicators. Conclusion: The levels of serum TSPO are decreased in patients with PPD, and the levels of Nesfestatin-1 and AngⅡare increased, which are related to the occurrence of PPD. The combined with TSPO, Nesfestatin-1 and AngⅡ has high value in the prediction of PPD occurrence risk. |
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