| 黄 建,翟红霞,秦晓新,赵 艳,李 思.维持性血液透析患者合并不宁腿综合征的影响因素分析及有氧运动改善效果的临床研究[J].,2023,(11):2053-2057 |
| 维持性血液透析患者合并不宁腿综合征的影响因素分析及有氧运动改善效果的临床研究 |
| Analysis of Influencing Factors in Maintenance Hemodialysis Patients Complicated with Restless Leg Syndrome and Clinical Study on Improvement Effect of Aerobic Exercise |
| 投稿时间：2022-12-23 修订日期：2023-01-18 |
| DOI：10.13241/j.cnki.pmb.2023.11.010 |
| 中文关键词: 维持性血液透析 不宁腿综合征 影响因素 有氧运动 疗效 |
| 英文关键词: Maintenance hemodialysis Restless leg syndrome Influencing factors Aerobic exercise Curative effect |
| 基金项目:北京市科技计划项目（Z171100000115064） |
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| 中文摘要: |
| 摘要 目的：分析维持性血液透析（MHD）患者合并不宁腿综合征（RLS）的影响因素，并探讨有氧运动对MHD合并RLS患者的改善效果。方法：选取2019年5月~2022年1月在首都医科大学附属北京朝阳医院进行MHD治疗的患者120例为研究对象。根据是否出现RLS将120例MHD患者分为合并RLS组（n=28）和未合并RLS组（n=92）。收集患者的临床资料，多因素Logistic回归分析MHD患者合并RLS的影响因素，并探讨有氧运动对MHD合并RLS患者的改善效果。结果：MHD合并RLS与性别、透析龄、高血压、饮酒史、收缩压、舒张压、血磷、维生素 B12（VitB12）、铁蛋白（SF）、同型半胱氨酸（Hcy）、血镁、β2微球蛋白（β2-MG）有关（P<0.05）。多因素Logistic回归分析结果显示：透析龄偏长、β2-MG偏高、VitB12偏高、Hcy偏高、饮酒史、SF偏低、血镁偏高、性别为女、血磷偏高是MHD合并RLS的危险因素（P<0.05）。干预12周后，MHD合并RLS患者的匹兹堡睡眠质量指数（PSQI）、焦虑自评量表（SAS）、抑郁自评量表（SDS）评分均较干预前下降（P<0.05）。结论：透析龄偏长、β2-MG偏高、VitB12偏高、Hcy偏高、饮酒史、SF偏低、血镁偏高、性别为女、血磷偏高均会增加MHD合并RLS的发生风险。有氧运动应用于MHD合并RLS患者，有助于改善患者的睡眠、抑郁和焦虑状况，效果较好。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the influencing factors of maintenance hemodialysis (MHD) patients complicated with restless leg syndrome (RLS), and to explore the improvement effect of aerobic exercise on MHD patients complicated with RLS. Methods: 120 patients who received MHD treatment in Beijing Chaoyang Hospital Affiliated to Capital Medical University from May 2019 to January 2022 were selected as subjects. According to the presence or absence of RLS, 120 MHD patients were divided into combined with RLS group (n=28) and non-combined with RLS group (n=92). Clinical data of patients were collected, and the influencing factors of MHD patients complicated with RLS were analyzed by multivariate Logistic regression, and the improvement effect of aerobic exercise on MHD patients complicated with RLS was discussed. Results: MHD complicated with RLS were associated with gender, dialysis age, hypertension, drinking history, systolic blood pressure, diastolic blood pressure, blood phosphorus, vitamin B12 (VitB12), ferritin (SF), homocysteine (Hcy), blood magnesium, β2 microglobulin (β2-MG) (P<0.05). The results of multivariate Logistic regression analysis showed that longer dialysis age, higher β2-MG, higher VitB12, higher Hcy, drinking history, lower SF, higher blood magnesium, gender with female and higher blood phosphorus were the risk factors for MHD complicated with RLS(P<0.05). 12 weeks after intervention, Pittsburgh Sleep Quality Index (PSQI), Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS) scores of MHD patients complicated with RLS decreased compared with those before intervention(P<0.05). Conclusion: The longer dialysis age, higher β2-MG, higher VitB12, higher Hcy, drinking history, lower SF, higher blood magnesium, gender with female, higher blood phosphorus all increase the risk of MHD complicated with RLS. Aerobic exercise in MHD patients complicated with RLS can help to improve the patients' sleep, depression and anxiety, and the effect is better. |
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