| 贾安佩,江 帆,孙莉静,单剑萍,蒋更如.原发性肾病综合征合并血栓栓塞的临床研究[J].,2023,(10):1988-1992 |
| 原发性肾病综合征合并血栓栓塞的临床研究 |
| Research of Thromboembolism Complications in Primary Nephrotic Syndrome |
| 投稿时间：2022-12-09 修订日期：2022-12-30 |
| DOI：10.13241/j.cnki.pmb.2023.10.036 |
| 中文关键词: 肺通气灌注扫描 血栓栓塞 肾病综合征 发生率 危险因素 |
| 英文关键词: Nephrotic syndrome Thromboembolic Pulmonary Ventilation / Perfusion imaging Incidence Risk factor |
| 基金项目:国家自然科学基金面上项目（81270823） |
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| 中文摘要: |
| 摘要 目的：肺栓塞及下肢深静脉血栓是影响肾病综合征(Nephrotic Syndrome，NS)预后的重要因素，但在其发生率以及治疗方面仍存在争议。本文将通过回顾性的病例研究对NS患者中血栓栓塞事件的发生率、危险因素以及是否需要早期干预等问题进行探讨。方法：收集上海交通大学医学院附属新华医院肾内科2014年1-12月诊断为原发性NS患者，并同时收集患者基本临床信息，血栓检查结果以及NS相关血液及尿液检查结果等在内的临床资料，采用多种统计方法分析血栓发生率及其危险因素，并进一步讨论NS患者的预防性抗凝措施。结果：NS患者下肢静脉血栓或肺栓塞的发生率均为15.4%，两种血栓同时发生的概率为9.6%。NS患者血栓事件的发生率与D-二聚体、血浆白蛋白、病程、病理类型呈明显相关，且具有统计学意义。结论：NS患者血栓栓塞的发生率与D-二聚体、血浆白蛋白、病程、病理类型呈显著相关，膜性肾病患者血栓栓塞发生率最高。如NS患者合并高危因素，建议定期筛查，综合评估后预防性抗凝。 |
| 英文摘要: |
| ABSTRACT Objective: Although thromboembolic events usually occurs in nephrotic syndrome (Nephrotic Syndrome, NS), the incidence and risk factors is still debatable. To further study the relevant problem, we performed a series of clinical research. Methods: All the NS patients between January to December in 2014 enrolled in nephrology department of Xinhua hospital were contained. The clinical data such as gender, duration of disease, pathological type, 24-hour urinary protein quantification, low density lipoprotein, platelet, plasma albumin, D-D dimer, fibrinogen were all collected. Variance analysis, T-test and Logistic regression analysis were all used to analyze the incidence of thrombosis and its risk factors. Meanwhile, the preventive anticoagulation measures for NS patients were further discussed. Results: Both of the incidences of PE and lower extremity DVT in NS were 15.4%. The incidence of cooccurrence of PE and DVT was 9.6%. The incidence of PE and DVT was significantly correlated with D-dimer, plasma albumin, course of disease and pathological type, which had statistical significance. Conclusion: The incidence of thrombosis in NS patients was significantly correlated with D-dimer, plasma albumin, duration of disease and pathological type, NS patients with high incidence of thromboembolism is suggested anticoagulation. |
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