| 张晶晶,王 超,王宏伟,齐凤娜,张 超,任素锋,李 磊,白京红,齐素青.无托槽隐形矫治器与固定矫治器对牙周病正畸治疗患者龈下菌群、龈沟液炎症因子和氧化应激的影响[J].,2023,(10):1945-1949 |
| 无托槽隐形矫治器与固定矫治器对牙周病正畸治疗患者龈下菌群、龈沟液炎症因子和氧化应激的影响 |
| Effects of Non Bracket Invisible Appliance and Fixed Appliance on Subgingival Flora, Gingival Crevicular Fluid Inflammatory Factors and Oxidative Stress in Patients with Periodontal Disease Undergoing Orthodontic Treatment |
| 投稿时间：2022-11-07 修订日期：2022-11-28 |
| DOI：10.13241/j.cnki.pmb.2023.10.027 |
| 中文关键词: 无托槽隐形矫治器 固定矫治器 牙周病 正畸治疗 龈下菌群 炎症因子 氧化应激 |
| 英文关键词: Non bracket invisible appliance Fixed appliance Periodontal disease Orthodontic treatment Subgingival flora Inflammatory factors Oxidative stress |
| 基金项目:河北省医学科学研究课题计划项目（20200030） |
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| 中文摘要: |
| 摘要 目的：对比固定矫治器与无托槽隐形矫治器对牙周病正畸治疗患者龈沟液炎症因子、龈下菌群和氧化应激的影响。方法：选取2016年1月～2021年10月于河北省眼科医院口腔正畸科接受正畸治疗的112例牙周病患者，根据矫治器的不同分为对照组（固定矫治器，n=54）和实验组（无托槽隐形矫治器，n=58）。对比两组牙周健康指标、龈下菌群、龈沟液炎症因子、氧化应激指标和疼痛评分的变化情况。结果：两组矫治10个月后牙龈指数、菌斑指数、龈沟出血指数、牙周探诊深度下降，且实验组低于对照组（P<0.05）。实验组矫治10个月后牙龈卟啉单胞菌（Pg）、具核梭杆菌（Fn）、福塞斯坦氏菌（Tf）和中间型普里沃菌（Pi）含量低于对照组（P<0.05）。两组矫治10个月后肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素1β（IL-1β）下降，且实验组低于对照组（P<0.05）。两组矫治10个月后丙二醛（MDA）、活性氧（ROS）水平下降，且实验组低于对照组；超氧化物歧化酶（SOD）升高，且实验组高于对照组（P<0.05）。两组矫治1 d、7 d后疼痛视觉模拟评分（VAS）评分升高后下降，且实验组低于对照组（P<0.05）。结论：无托槽隐形矫治器与固定矫治器对牙周病正畸治疗患者均有较好的疗效，其中无托槽隐形矫治器在改善牙周健康指标、龈下菌群、龈沟液炎症因子和氧化应激等方面的效果较为显著。 |
| 英文摘要: |
| ABSTRACT Objective: To compare the effects of fixed appliance and non bracket invisible appliance on gingival crevicular fluid inflammatory factors, subgingival flora and oxidative stress in patients with periodontal disease undergoing orthodontic treatment. Methods: 112 patients with periodontal disease who received orthodontic treatment in the Orthodontic Department of Hebei Provincial Eye Hospital from January 2016 to October 2021 were selected, and they were divided into the control group (fixed appliance, n=54) and the experimental group (non bracket invisible appliance, n=58) according to the different of appliance. The changes of periodontal health indicators, subgingival microflora, gingival crevicular fluid inflammatory factors, oxidative stress indicators and pain scores were compared in the two groups. Results: 10 months after correction, the gingival index, plaque index, gingival sulcus bleeding index and periodontal probing depth in the two groups decreased, and the experimental group was lower than the control group(P<0.05). 10 months after correction, the contents of Porphyromonas gingivalis (Pg), Fusobacterium nucleatum (Fn), Pseudomonas forsythiae (Tf) and Prevotella intermedia (Pi) in the experimental group were lower than those in the control group (P<0.05). The tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) in the two groups at 10 months after correction decreased, and the experimental group was lower than the control group (P<0.05). 10 months after correction, the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) in two groups decreased, and the experimental group was lower than the control group. Superoxide dismutase (SOD) increased, and the experimental group was higher than the control group(P<0.05). The visual analogue score(VAS) of pain in the two groups increased and decreased at 1d and 7d after correction, and the experimental group was lower than the control group(P<0.05). Conclusion: Both non bracket invisible appliance and fixed appliance have good curative effect on periodontal orthodontic treatment, among which the non bracket invisible appliance has a significant effect on improving periodontal health indicators, subgingival microflora, inflammatory factors of gingival crevicular fluid and oxidative stress. |
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