| 宋淑然,高军萍,付 洁,靳建坤,刘 菲.血清GDF-15、FGF21与非酒精性脂肪性肝病患者肝纤维化和代谢综合征的关系研究[J].,2023,(10):1915-1919 |
| 血清GDF-15、FGF21与非酒精性脂肪性肝病患者肝纤维化和代谢综合征的关系研究 |
| Relationship Study between Serum GDF-15 and FGF21 and Hepatic Fibrosis and Metabolic Syndrome in Patients with Nonalcoholic Fatty Liver Disease |
| 投稿时间：2022-11-06 修订日期：2022-11-30 |
| DOI：10.13241/j.cnki.pmb.2023.10.021 |
| 中文关键词: 非酒精性脂肪性肝病 GDF-15 FGF21 肝纤维化 代谢综合征 |
| 英文关键词: Nonalcoholic fatty liver disease GDF-15 FGF21 Liver fibrosis Metabolic syndrome |
| 基金项目:河北省卫生健康委员会科研基金项目（20160552） |
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| 中文摘要: |
| 摘要 目的：研究血清生长分化因子15（GDF-15）、成纤维细胞生长因子21（FGF21）与非酒精性脂肪性肝病（NAFLD）患者肝纤维化和代谢综合征（MS）的关系。方法：选取我院2019年1月～2021年2月收治的102例NAFLD患者记作研究组。另选取同期健康体检志愿者100例作为对照组。比较两组血清GDF-15、FGF21与肝纤维化指标水平，并采用Pearson相关性分析明确血清GDF-15、FGF21与肝纤维化指标水平的关系。此外，将研究组患者按照是否并发MS分为MS组以及非MS组，比较MS组以及非MS组血清GDF-15、FGF21水平以及基线资料。采用多因素Logistic回归分析NAFLD并发MS的影响因素。结果：研究组血清GDF-15、FGF21水平高于对照组（均P＜0.05）。研究组血清透明质酸（HA）、层粘连蛋白（LN）、Ⅲ型前胶原（PCⅢ）以及Ⅳ型胶原（ⅣC）水平高于对照组（均P＜0.05）。经Pearson相关性分析发现，血清GDF-15、FGF21水平与血清HA、LN、PCⅢ、ⅣC水平均呈正相关关系（均P＜0.05）。经单因素分析发现，血清天冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、GDF-15、FGF21水平以及体质量指数、空腹血糖（FPG）、餐后2小时血糖（2hPG）、收缩压（SBP）、舒张压（DBP）、甘油三酯（TG）均和MS有关（均P＜0.05）。经多因素Logistic回归分析发现，血清AST、ALT升高是NAFLD并发MS的保护因素，而体质量指数、GDF-15、FGF21、FPG、2hPG、SBP、DBP、TG升高均是NAFLD并发MS的危险因素（均P＜0.05）。结论：血清GDF-15、FGF21与NAFLD患者肝纤维化以及MS均密切相关，可作为预测NAFLD患者肝纤维化以及MS的辅助性生物学指标。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between serum growth differentiation factor 15 (GDF-15), fibroblast growth factor 21 (FGF21) and liver fibrosis and metabolic syndrome (MS) in patients with nonalcoholic fatty liver disease (NAFLD). Methods: 102 patients with NAFLD who were admitted to our hospital from January 2019 to February 2021 were enrolled as the study group. Another 100 physical examination volunteers in the same period were selected as the control group. Serum GDF-15, FGF21 and liver fibrosis indicators levels were compared in the two groups, and Pearson correlation analysis was used to determine the relationship between serum GDF-15, FGF21 and liver fibrosis indicators levels. In addition, patients in the study group were divided into MS group and non-MS group according to whether they had concurrent MS. Serum GDF-15 and FGF21 levels and baseline data in the MS group and non-MS group were compared. Multivariate Logistic regression analysis was used to determine the influencing factors of NAFLD complicated with MS. Results: The serum GDF-15 and FGF21 levels in the study group were higher than those in the control group (all P<0.05). The serum hyaluronic acid (HA), laminin (LN), type Ⅲ precollagen (PCⅢ) and type Ⅳ collagen (ⅣC) levels in the study group were higher than those in the control group (all P<0.05). Pearson correlation analysis showed that serum GDF-15 and FGF21 levels were positively correlated with serum HA, LN, PCⅢ and ⅣC levels (all P<0.05). Univariate analysis showed that serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), GDF-15 and FGF21, as well as body mass index, fasting blood glucose (FPG), 2-hour postprandial blood glucose (2hPG), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG) were correlated with MS(all P<0.05). Multivariate Logistic regression analysis showed that the increase of serum AST and ALT was the protective factor for NAFLD complicated with MS, while the increase of body mass index, GDF-15, FGF21, FPG, 2hPG, SBP, DBP and TG was the risk factor for NAFLD complicated with MS (all P<0.05). Conclusion: Serum GDF-15 and FGF21 are closely related to liver fibrosis and MS in patients with NAFLD, and which can be used as auxiliary biological indicators to predict liver fibrosis and MS in patients with NAFLD. |
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