| 张慧如,曹 宁,张星光,陈 超,田 乐.合欢解郁汤联合草酸艾司西酞普兰片治疗老年抑郁症患者疗效及对hs-CRP影响[J].,2023,(10):1902-1906 |
| 合欢解郁汤联合草酸艾司西酞普兰片治疗老年抑郁症患者疗效及对hs-CRP影响 |
| Effect of Hehuan Jieyu Decoction Combined with Escitalopram Oxalate Tablets in the Treatment of Senile Depression and Its Effect on hs-CRP |
| 投稿时间：2022-10-19 修订日期：2022-11-15 |
| DOI：10.13241/j.cnki.pmb.2023.10.018 |
| 中文关键词: 合欢解郁汤 草酸艾司西酞普兰片 老年抑郁症 |
| 英文关键词: Hehuan Jieyu Decoction Escitalopram oxalate tablets Elderly depression |
| 基金项目:内蒙古自治区自然科学基金项目（2020MS08048） |
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| 中文摘要: |
| 摘要 目的：探究合欢解郁汤联合草酸艾司西酞普兰片在治疗老年抑郁症患者中的疗效，并分析治疗对患者超敏C反应蛋白（hs-CRP）水平的影响。方法：选择2021年2月至2022年1月在我院接受治疗的80例老年抑郁症患者为研究对象，将其均分为实验组与对照组（各40例），对照组患者接受常规草酸艾司西酞普兰片治疗，实验组患者在对照组基础上加用合欢解郁汤治疗，对比两组患者治疗效果，治疗前后汉密尔顿抑郁量表（HAMD）、匹兹堡睡眠质量指数（PSQI）、自杀意念自评量表（SIOSS）、白细胞介素-6（IL-6）、hs-CRP水平，并记录对比两组患者治疗中不良反应发生率。结果：（1）实验组患者治疗有效率为97.50 %，对照组为85.00 %，两组比较差异明显（P<0.05）；（2）治疗前两组患者HAMD及PSQI评分差异不大，治疗后实验组患者上述量表评分均低于对照组（P<0.05）；（3）治疗前两组患者SIOSS量表各维度评分差异不大（P>0.05），治疗后实验组患者绝望因子、乐观因子、睡眠因子和掩饰因子得分均低于对照组（P<0.05）；（4）治疗前两组患者IL-6和hs-CRP水平差异不大（P>0.05），治疗后实验组IL-6和hs-CRP水平均低于对照组（P<0.05）；（5）两组患者不良反应发生率差异不大（P>0.05）。结论：合欢解郁汤联合草酸艾司西酞普兰片对老年抑郁症具有较好疗效，能改善抑郁症状，降低其自杀风险以及炎症因子水平，同时治疗安全性较高。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the efficacy of Hehuan Jieyu Decoction combined with milnacipran in the treatment of elderly patients with depression, and to analyze the effect of treatment on the level of hypersensitive C-reactive protein (hs-CRP) in patients. Methods: Eighty elderly patients with depression who received treatment in our hospital from February 2021 to January 2022 were selected as the research object, and they were divided into an experimental group and a control group (40 patients in each group) according to the random number table method. Patients in the control group were treated with esccitalopram oxalate tablets, and patients in the experimental group were treated with Hehuan Jieyu Decoction on the basis of the control group. The therapeutic effects of the two groups were compared. The Hamilton Depression Scale (HAMD) and Pittsburgh Sleep Quality Index (PSQI) before and after treatment, Suicide Ideas Self-Assessment Scale (SIOSS), interleukin-6 (IL-6), hs-CRP levels, and record and compare the incidence of adverse reactions in the two groups of patients during treatment. Results: (1) The effective rate of treatment in the experimental group was 97.50% and that in the control group was 85.00 %. The difference between the two groups was significant (P<0.05). (2) The HAMD and PSQI scores of the two groups before treatment were not different. The scores of the above-mentioned scales in the experimental group were lower than those in the control group (P<0.05). (3) The scores of the SIOSS scales of the two groups before treatment were not different (P>0.05). After treatment, the despair factor and optimism of the patients in the experimental group The scores of factor, sleep factor and concealment factor were lower than those of the control group(P<0.05). (4) The levels of IL-6 and hs-CRP of the two groups of patients before treatment were not different (P>0.05). IL-6 and hs-CRP levels were lower than those of the control group (P<0.05). (5) There was no difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Hehuan Jieyu Decoction combined with milnacipran has a good therapeutic effect on senile depression, which can significantly improve patients' depressive symptoms, reduce their suicide risk and inflammatory factor levels, and at the same time, the treatment is safer. |
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