| 常 琳,高永红,赵 洲,连雪梅,李亚男.血清Klotho蛋白、视锥蛋白样蛋白-1、高迁移率族蛋白1与阿尔茨海默病患者认知功能和预后不良的关系[J].,2023,(9):1706-1711 |
| 血清Klotho蛋白、视锥蛋白样蛋白-1、高迁移率族蛋白1与阿尔茨海默病患者认知功能和预后不良的关系 |
| Relationship between Serum Klotho Protein, Visinin-Like Protein 1, High Mobility Group Box 1 Protein and Cognitive Function and Poor Prognosis in Patients with Alzheimer's Disease |
| 投稿时间：2022-10-07 修订日期：2022-10-30 |
| DOI：10.13241/j.cnki.pmb.2023.09.021 |
| 中文关键词: 阿尔兹海默病 高迁移率族蛋白1 视锥蛋白样蛋白-1 Klotho蛋白 认知功能 预后 |
| 英文关键词: Alzheimer's disease High mobility group box 1 protein Visinin-like protein 1 Klotho protein Cognitive function Prognosis |
| 基金项目:北京市自然科学基金项目（8183291） |
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| 中文摘要: |
| 摘要 目的：探讨阿尔兹海默病（AD）患者血清Klotho蛋白、视锥蛋白样蛋白-1（VILIP-1）、高迁移率族蛋白1（HMGB1）与认知功能及预后的关系。方法：选取2019年4月-2021年5月在我院接受治疗的136例AD患者作为AD组，另选取150例同时期在我院进行体检的健康志愿者作为对照组，应用酶联免疫吸附法检测两组血清Klotho蛋白、VILIP-1、HMGB1表达水平，采用简易精神状态检查量表（MMSE）评估两组认知功能，采用Pearson相关性分析以上三指标与MMSE评分之间的关系；AD患者根据治疗1年后的预后情况分为预后良好组（n=74）与预后不良组（n=62），应用单因素、多因素Logistic回归分析引发AD患者预后不良的危险因素；采用受试者工作特征（ROC）曲线评估血清Klotho蛋白、VILIP-1、HMGB1联合检测对AD患者预后的预测效能。结果：AD组的MMSE评分、血清Klotho蛋白水平显著低于对照组，而血清VILIP-1及HMGB1水平显著高于对照组（均P＜0.05）；Pearson相关性结果显示血清Klotho蛋白水平与MMSE评分之间呈显著正相关（P＜0.05），而血清VILIP-1、HMGB1水平与MMSE评分之间呈显著负相关（均P＜0.05）；多因素Logistic回归分析显示血清VILIP-1、HMGB1水平升高是引发AD患者预后不良的独立危险因素，而血清Klotho蛋白水平升高是其保护因素（P＜0.05）；ROC曲线显示 Klotho蛋白、VILIP-1、HMGB1联合检测AD患者曲线下面积为0.839，敏感度为80.65%，特异度为83.78%。结论：血清Klotho蛋白、VILIP-1、HMGB1表达水平与AD患者认知功能和预后均具有较强的关联性，临床可以通过联合检测以上三指标辅助评估AD患者的预后。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum Klotho protein, visinin-like protein 1 (VILIP-1), high mobility group box 1 protein (HMGB1) and cognitive function and prognosis in patients with Alzheimer's disease (AD). Methods: 136 patients with AD who received treatment in our hospital from April 2019 to May 2021 were selected as the AD group, and another 150 healthy volunteers who underwent physical examination in our hospital during the same period were selected as the control group. The expression levels of serum Klotho protein, VILIP-1 and HMGB1 in the two groups were detected by enzyme-linked immunosorbent assay. The cognitive function in the two groups was assessed by the Mini-Mental State Examination Scale (MMSE), and the relationship between the above three indicators and MMSE score was analyzed by Pearson correlation. The patients with AD were divided into good prognosis group (n=74) and poor prognosis group (n=62) according to the prognosis at 1 year after treatment. Univariate and multivariate Logistic regression were used to analyze the risk factors of poor prognosis in patients with AD. Receiver operating characteristic (ROC) curve was used to evaluate the predictive efficacy of combined detection of serum Klotho protein, VILIP-1 and HMGB1 in patients with AD. Results: MMSE score and serum Klotho protein level in the AD group were significantly lower than those in the control group, while serum VILIP-1 and HMGB1 levels were significantly higher than those in the control group (all P＜0.05). Pearson correlation results showed that serum Klotho protein level was significantly positively correlated with MMSE score (P＜0.05), while serum VILIP-1 and HMGB1 levels were significantly negatively correlated with MMSE score (all P＜0.05). Multivariate Logistic regression analysis showed that increased serum VILIP-1 and HMGB1 levels were independent risk factors for poor prognosis in patients with AD, while increased serum Klotho protein level was a protective factor (P＜0.05). ROC curve showed that the area under the curve of Klotho protein, VILIP-1 and HMGB1 in the combined detection of patients with AD was 0.839, the sensitivity was 80.65%, and the specificity was 83.78%. Conclusion: The serum Klotho protein, VILIP-1 and HMGB1 expression levels are strongly correlated with the cognitive function and prognosis of patients with AD, and the above three indicators can be used to assist the prognosis assessment of patients with AD. |
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