| 戴蓉芳,徐明然,胡 颖,施惠华,冯月英.血清尿酸、白介素6、P-tau181与阿尔茨海默病患者认知功能、日常生活能力和预后的关系分析[J].,2023,(8):1447-1452 |
| 血清尿酸、白介素6、P-tau181与阿尔茨海默病患者认知功能、日常生活能力和预后的关系分析 |
| Relationship Analysis between Serum Uric Acid, Interleukin-6, P-tau181 and Cognitive Function, Ability of Daily Living and Prognosis in Patients with Alzheimer's Disease |
| 投稿时间：2022-10-23 修订日期：2022-11-18 |
| DOI：10.13241/j.cnki.pmb.2023.08.009 |
| 中文关键词: 阿尔茨海默病 尿酸 白细胞介素-6 P-tau181 认知功能 预后 |
| 英文关键词: Alzheimer's disease Uric acid Interleukin-6 P-tau181 Cognitive function Prognosis |
| 基金项目:上海市科学技术委员会科研计划项目（17DZ1941606）；上海市黄浦区科委科研项目（HKM201912） |
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| 中文摘要: |
| 摘要 目的：探讨血清尿酸（UA）、白细胞介素-6（IL-6）、磷酸化Tau181（P-tau181）与阿尔茨海默病（AD）患者认知功能、日常生活能力和预后的关系。方法：选择2018年5月至2021年1月上海交通大学医学院附属第九人民医院与上海交通大学医学院附属第九人民医院黄浦分院收治的98例AD患者（AD组）和71例门诊体检的健康志愿者（对照组），检测血清UA、IL-6、P-tau181水平，使用简易智力状态检查量表（MMSE）、蒙特利尔认知评估量表（MoCA）评估患者认知功能，Barthel指数（BI）评估患者日常生活能力。所有患者出院后随访1年，统计随访期间不良预后发生情况。Pearson相关性分析UA、IL-6、P-tau181与MMSE、MoCA、BI的相关性，多因素Logistic回归分析AD患者预后不良的危险因素。结果：AD组血清UA水平和MMSE、MoCA评分、BI低于对照组（P＜0.05），IL-6、P-tau181水平高于对照组（P＜0.05）。AD患者血清UA水平与MMSE、MoCA评分、BI呈正相关（P＜0.05），IL-6、P-tau181水平与MMSE、MoCA评分、BI呈负相关（P＜0.05）。多因素Logistic回归分析结果显示：长期卧床、AD痴呆阶段、高水平IL-6、高水平P-tau181是AD患者预后不良的危险因素（P＜0.05），高水平UA是保护因素（P＜0.05）。结论：AD患者血清UA水平降低，IL-6、P-tau181水平升高，且与认知功能障碍、日常生活能力降低以及预后不良有关，检测血清UA、IL-6、P-tau181可辅助评估AD病情和预后。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum uric acid (UA), interleukin-6 (IL-6), phosphorylated Tau181 (P-tau181) and cognitive function, daily living ability and prognosis in patients with Alzheimer's disease (AD). Methods: From May 2018 to January 2021,98 patients with AD (AD group) who were admitted to Ninth People's Hospital, Shanghai Jiaotong University School of Medicine and Huangpu Branch of Ninth People's Hospital,Shanghai Jiaotong University School of Medicine and 71 healthy volunteers for outpatient physical examination (control group) were selected, serum UA, IL-6 and P-tau181 levels were detected, and the cognitive function of patients was assessed with the Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment Scale (MoCA), and the ability of daily living of patients was assessed with the Barthel index (BI). All patients were followed up for 1 year after discharge, and the adverse prognosis during the follow-up period was counted. Pearson correlation analysis showed the correlation between UA, IL-6, P-tau181 and MMSE, MoCA, BI. Multivariate Logistic regression analysis showed the risk factors of poor prognosis in patients with AD. Results: Serum UA level, MMSE, MoCA score and BI in the AD group were lower than those in the control group (P<0.05), while IL-6 and P-tau181 levels were higher than those in control group (P<0.05). Serum UA level in patients with AD was positively correlated with MMSE, MoCA score and BI(P<0.05), while IL-6 and P-tau181 levels were negatively correlated with MMSE, MoCA score and BI(P<0.05). Multivariate Logistic regression analysis showed that long-term bed rest, stage of AD dementia, high level of IL-6 and high level of P-tau181 were risk factors for poor prognosis of patients with AD (P<0.05), and high level of UA was protective factor (P<0.05). Conclusion: The serum UA level in patients with AD is decreased, and the IL-6 and P-tau181 levels are increased, which are related to cognitive dysfunction, decreased ability of daily living and poor prognosis. The detection of serum UA, IL-6 and P-tau181 can assist in evaluating the condition and prognosis of AD. |
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