| 郭 仙,黄 芳,方 立,李莉英,吴 涛,崔腾香.不同康复训练频率对急性心肌梗死患者PCI术后心肺运动耐量、炎症转录因子及生活质量的影响[J].,2023,(6):1196-1200 |
| 不同康复训练频率对急性心肌梗死患者PCI术后心肺运动耐量、炎症转录因子及生活质量的影响 |
| Effects of Different Rehabilitation Training Frequency on Cardiopulmonary Exercise Tolerance, Inflammatory Transcription Factors and Quality of Life in Patients with Acute Myocardial Infarction after PCI |
| 投稿时间：2023-01-03 修订日期：2023-01-28 |
| DOI：10.13241/j.cnki.pmb.2023.06.039 |
| 中文关键词: 康复训练 急性心肌梗死 经皮冠状动脉介入术 心肺功能 运动耐量 炎症转录因子 生活质量 |
| 英文关键词: Rehabilitation training Acute myocardial infarction Percutaneous coronary intervention Cardiopulmonary function Exercise tolerance Inflammatory transcription factors Quality of life |
| 基金项目:湖南省卫生健康委科研计划项目（202203012990） |
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| 摘要 目的：探讨不同康复训练频率对急性心肌梗死（AMI）患者经皮冠状动脉介入（PCI）术后炎症转录因子、心肺运动耐量、生活质量的影响。方法：根据随机数字表法将长沙市第一医院2021年1月-2022年10月期间收治的92例PCI术后行康复训练的AMI患者分为A组（n=31，康复训练12次）、B组（n=31，康复训练24次）、C组（n=30，康复训练36次）。比较三组患者心功能指标[左室收缩末期内径（LVESD）、左心室射血分数（LVEF）、左室舒张末期内径（LVEDD）、运动耐力[6 min步行试验（6MWT）]、肺功能指标[第1秒用力呼气容积（FEV1）、用力肺活量（FVC）、呼气峰值流速（PEF）]、炎症转录因子[可溶性细胞间黏附分子-1（sICAM-1）、核因子-kB（NF-kB）]及生活质量变化情况。结果：B组、C组干预后LVEF、6MWT高于A组，且C组高于B组（P<0.05），B组、C组干预后LVESD、LVEDD小于A组，且C组小于B组（P<0.05）。B组、C组干预后FEV1、FVC、PEF高于A组，且C组高于B组（P<0.05）。B组、C组干预后sICAM-1、NF-kB低于A组，且C组低于B组（P<0.05）。B组、C组干预后健康调查量表（SF-36）各维度评分高于A组，且C组高于B组（P<0.05）。结论：AMI患者PCI术后进行康复训练，可有效改善心肺运动耐量，降低炎症转录因子水平，提高生活质量，且随着康复训练频率的增加，患者的改善效果越好，建议临床康复训练频率应不少于36次。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of different rehabilitation training frequency on inflammatory transcription factors, cardiopulmonary exercise tolerance and quality of life in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Methods: According to random number table method,92 rehabilitation training for patients with AMI in Changsha First Hospital from January 2021 to October 2022 were divided into group A (n=31, 12 times of rehabilitation training), group B (n=31, 24 times of rehabilitation training) and group C (n=30, 36 times of rehabilitation training). Cardiac function indexes [left ventricular end-systolic dimension (LVESD), left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD)], exercise endurance [6min walking test (6MWT)], pulmonary function indexes [forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), peak expiratory flow rate (PEF), inflammatory transcription factors [soluble intercellular adhesion molecule-1 (sICAM-1), nuclear factor-KB (NF-kB)] and quality of life changes of patients in the three groups were compared. Results: After intervention, LVEF and 6MWT in the group B and group C were higher than those in the group A, and the group C was higher than the group B (P<0.05). After intervention, LVESD and LVEDD in the group B and group C were lower than those in the group A, and the group C was lower than the group B (P<0.05). After intervention, FEV1, FVC and PEF in the group B and group C were higher than those in the group A, and the group C was higher than the group B (P<0.05). After intervention, sICAM-1 and NF-kB in the group B and group C were lower than those in the group A, and group C was lower than the group B (P<0.05). The score of each dimension of the Short form 36 Health Survey Questionnaire (SF-36) after intervention in the group B and group C was higher than that in the group A, and the group C was higher than the group B (P<0.05). Conclusion: Rehabilitation training for patients with AMI after PCI can effectively improve cardiopulmonary exercise tolerance, reduce the level of inflammatory transcription factors, and improve the quality of life. With the increase of the rehabilitation training frequency, the better the improvement effect of patients, it is recommended that the clinical rehabilitation training frequency should be no less than 36 times. |
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