| 薛伊晴,李 倩,周 洁,张 湘,张 莉.消疬膏对脾胃虚弱证颈部淋巴结核患者CD4+CD25highFoxP3+调节性T淋巴细胞和胃肠激素的影响[J].,2023,(3):510-514 |
| 消疬膏对脾胃虚弱证颈部淋巴结核患者CD4+CD25highFoxP3+调节性T淋巴细胞和胃肠激素的影响 |
| Effect of Xiaoli Ointment on CD4+CD25highFoxP3+ Regulatory T Lymphocytes and Gastrointestinal Hormones in Patients with Cervical Lymph Tuberculosis of Spleen and Stomach Weakness Syndrome |
| 投稿时间：2022-05-21 修订日期：2022-06-18 |
| DOI：10.13241/j.cnki.pmb.2023.03.022 |
| 中文关键词: 消疬膏 脾胃虚弱证 颈部淋巴结核 CD4+CD25highFoxP3+调节性T淋巴细胞 胃肠激素 |
| 英文关键词: Xiaoli ointment Spleen stomach weakness syndrome Cervical lymph tuberculosis CD4+CD25highFoxP3+ regulatory T lymphocytes Gastrointestinal hormone |
| 基金项目:江苏省"十二五"中医重点学科建设项目（苏中医政[2013]30号） |
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| 摘要 目的：研究消疬膏对脾胃虚弱证颈部淋巴结核患者CD4+CD25highFoxP3+调节性T淋巴细胞和胃肠激素的影响。方法：选择南京市中西医结合医院于2020年3月~2022年1月期间收治的颈部淋巴结核患者120例。按照随机数字表法分为对照组（60例）和研究组（60例）。对照组接受常规抗结核方案，研究组接受消疬膏联合常规抗结核方案，两组疗程均为6个月。观察两组治疗前和治疗6个月后的中医证候积分、CD4+CD25highFoxP3+调节性T淋巴细胞相关指标和胃肠激素的变化，记录两组治疗期间用药安全性。结果：两组治疗6个月后肿疡大小、肿疡皮色、面色、纳呆、倦怠乏力、便溏、舌质、脉象评分均下降，且研究组低于对照组（P<0.05）。研究组治疗6个月后CD4+CD25highFoxP3+调节性T淋巴细胞、白介素-10（IL-10）水平低于对照组，γ-干扰素（IFN-γ）水平高于对照组（P<0.05）。研究组治疗6个月后胆囊收缩素（CCK）、胃泌素（GAS）水平低于对照组，胃动素（MTL）水平高于对照组（P<0.05）。研究组的不良反应总发生率低于对照组（P<0.05）。结论：消疬膏治疗脾胃虚弱证颈部淋巴结核患者，可有效改善患者临床症状，可能与调节CD4+CD25highFoxP3+调节性T淋巴细胞和胃肠激素水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the effect of Xiaoli ointment on CD4+CD25highFoxP3+ regulatory T lymphocytes and gastrointestinal hormones in patients with cervical lymph tuberculosis of spleen stomach weakness syndrome. Methods: 120 patients with cervical lymph tuberculosis who were admitted to Nanjing Intergrated Traditional Chinese And Western Medicine Hospital from March 2020 to March 2022 were selected. According to the random number table method, they were divided into control group (60 cases) and study group (60 cases). The control group received routine anti-tuberculosis regimen, and the study group received Xiaoli ointment combined with routine anti-tuberculosis regimen. The course of treatment in the two groups was 6 months. The changes of traditional Chinese medicine syndrome score, CD4+CD25highFoxP3+ regulatory T lymphocyte related indexes and gastrointestinal hormones before and 6 months after treatment were observed in the two groups, and the medication safety during treatment in the two groups was recorded. Results: 6 months after treatment, the swelling size, swellin skin color, complexion, nauseatness, fatigue and lack of strength, loose stool, tongue nature and pulse condition scores in the two groups were all decreased, and the study group was lower than the control group (P<0.05). 6 months after treatment, the levels of CD4+CD25highFoxP3+ regulatory T lymphocytes and interleukin-10(IL-10) in the study group were lower than those in the control group, and the level of interferon-γ (IFN-γ) was higher than that in the control group (P<0.05). 6 months after treatment, the levels of cholecystokinin (CCK) and gastrin (GAS) in the study group were lower than those in the control group, and the level of motilin (MTL) was higher than that in the control group (P<0.05). The total incidence of adverse reactions in the study group was lower than that in the control group (P<0.05). Conclusion: Xiaoli ointment can effectively improve the clinical symptoms of patients with cervical lymph tuberculosis of spleen stomach weakness syndrome, which may be related to the regulation of CD4+CD25highFoxP3+ regulatory T lymphocytes and the levels of gastrointestinal hormone. |
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