| 秦海荣,秦 艳,王晓林,冀 璐,毛晓玲.手足口病合并脑炎患儿外周血T淋巴细胞亚群、血清VCAM-1及CRP的表达水平及其检测价值分析[J].,2023,(2):336-339 |
| 手足口病合并脑炎患儿外周血T淋巴细胞亚群、血清VCAM-1及CRP的表达水平及其检测价值分析 |
| Expression Levels of Peripheral Blood T Lymphocyte Subsets, Serum VCAM-1 and CRP in Children with Hand, Foot and Mouth Disease Combined with Encephalitis and Their Detection Value |
| 投稿时间：2022-05-06 修订日期：2022-06-03 |
| DOI：10.13241/j.cnki.pmb.2023.02.025 |
| 中文关键词: 手足口病 脑炎 外周血 T淋巴细胞亚群 血管细胞粘附分子-1 C-反应蛋白 |
| 英文关键词: Hand, Foot and mouth disease Encephalitis Peripheral blood T lymphocyte subsets Vascular cell adhesion molecule-1 C-reactive protein |
| 基金项目:山西省重点研发计划项目（201803D31163） |
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| 中文摘要: |
| 摘要 目的：探讨与分析手足口病（HFMD）合并脑炎患儿外周血T淋巴细胞亚群、血清VCAM-1及CRP的表达水平及其检测价值。方法：2017年4月到2020年10月选择在本院诊治的手足口病合并脑炎患儿42例作为合并组，同期选择手足口病不合并脑炎患儿68例作为对照组，检测两组外周血T淋巴细胞亚群、血清血管细胞粘附分子-1（VCAM-）及C-反应蛋白（CRP）表达水平，并判断检测价值与进行相关性分析。结果：合并组的CD4+、CD8+T淋巴细胞相对比例都明显少于对照组（P<0.05）。合并组的血清VCAM-1及CRP含量明显高于对照组（P<0.05）。在80例患儿中，Spearsman分析显示CD4+、CD8+T淋巴细胞相对比例和血清VCAM-1、CRP含量都与手足口病合并脑炎的发生存在相关性（P<0.05）。二分类Logistic回归分析显示CD4+、CD8+T淋巴细胞相对比例和血清VCAM-1、CRP含量都为导致手足口病合并脑炎发生的重要因素（P<0.05）。结论：手足口病合并脑炎患儿多伴随有外周血T淋巴细胞亚群异常与血清VCAM-1、CRP的高表达，CD4+、CD8+T淋巴细胞相对比例、血清VCAM-1、CRP含量都为导致手足口病合并脑炎发生的重要因素。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate and analysis the expression levels and detection value of peripheral blood T lymphocyte subsets, serum VCAM-1 and CRP in children with hand-foot-mouth disease (HFMD) combined with encephalitis. Methods: From April 2017 to October 2020, 42 cases of children with HFMD and encephalitis who were diagnosed and treated in our hospital were selected as the combined group, and 68 children with HFMD without encephalitis were selected as the control group during the same period. The expression levels of peripheral blood T lymphocyte subsets, serum Vascular Cell Adhesion Molecule-1 (VCAM-1) and C-reactive protein (CRP) in the peripheral blood of the group were determined, and the detection value were judged and given correlation analysis. Results: The relative proportions of CD4+ and CD8+T lymphocytes in the combined group were lower than those in the control group (P<0.05). The serum VCAM-1 and CRP levels in the combined group were significantly higher than those in the control group (P<0.05). In the 80 children, Spearsman analysis showed that the relative proportions of CD4+ and CD8+T lymphocytes and the levels of serum VCAM-1 and CRP were correlated with the occurrence of HFMD combined with encephalitis (P<0.05). Binary Logistic regression analysis showed that the relative proportions of CD4+ and CD8+T lymphocytes and the levels of serum VCAM-1 and CRP were important factors for the occurrence of HFMD combined with encephalitis (P<0.05). Conclusion: Children with hand, foot and mouth disease combined with encephalitis are often accompanied by abnormal peripheral blood T lymphocyte subsets and high expression of serum VCAM-1 and CRP. It is an important factor leading to the occurrence of hand, foot and mouth disease combined with encephalitis. |
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