| 王 星,李小忠,宁 峰,董玉婷,江 静.非小细胞肺癌组织中NF-κB p65与PD-1、PD-L1表达的相关性以及对预后的预测价值分析[J].,2023,(2):313-317 |
| 非小细胞肺癌组织中NF-κB p65与PD-1、PD-L1表达的相关性以及对预后的预测价值分析 |
| Analysis of Correlation between NF-κB p65 and PD-1, PD-L1 in Non-small Cell Lung Cancer Tissues and Its Prognostic Value |
| 投稿时间：2022-05-12 修订日期：2022-06-10 |
| DOI：10.13241/j.cnki.pmb.2023.02.021 |
| 中文关键词: 非小细胞肺癌 核因子-κB 程序性死亡受体1 程序性死亡配体1 |
| 英文关键词: Non-small cell lung cancer Nuclear factor-κB Programmed cell death-1 Programmed death ligand-1 |
| 基金项目:陕西省自然科学基础研究计划项目（2017JQ8027） |
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| 中文摘要: |
| 摘要 目的：研究非小细胞肺癌（NSCLC）组织中核因子-κB（NF-κB）与程序性死亡受体1（PD-1）和程序性死亡配体1（PD-L1）表达的相关性以及对预后的预测价值。方法：回顾性收集2014年7月至2017年6月期间我院收治的NSCLC患者的临床资料和病理组织标本共80例作为研究对象，另选取同期30例癌旁正常肺组织，免疫组化法检测组织中NF-κB p65、PD-1和PD-L1的表达情况，分析PD-1和PD-L1表达的影响因素及与p65的相关性，Logistic回归分析影响患者预后的因素，分析p65、PD-1和PD-L1表达与患者预后的关系。结果：NSCLC组织中的p65、PD-1和PD-L1的阳性表达率均显著高于正常对照组织（P＜0.05）。TNM分期、分化程度、淋巴结是否转移和p65表达为影响PD-1和PD-L1表达的因素（P＜0.05）。Pearson相关性分析结果表明，p65与PD-1、PD-L1呈正相关（P＜0.05）。TNM分期、分化程度、淋巴结转移、p65、PD-1和PD-L1的表达均为影响NSCLC患者预后的独立危险因素。p65、PD-1和PD-L1阴性表达组患者的总生存期（OS）显著长于p65、PD-1和PD-L1阳性表达患者（P＜0.05）。结论：NF-κB p65与PD-1、PD-L1的表达密切相关，p65、PD-1和PD-L1的表达情况对NSCLC患者的预后具有较高的预测价值。 |
| 英文摘要: |
| ABSTRACT Objective: To analysis the correlation between nuclear factor-κB(NF-κB) p65 and programmed cell death-1(PD-1), programmed death ligand-1(PD-L1) in non-small cell lung cancer(NSCLC) tissues and its prognostic value. Methods: 80 NSCLS cases clinical datas and pathological specimens from July 2014 to June 2017 were collected as research objects, another 30 normal lung tissues were collected as control group, the expression of NF-κB p65, PD-1 and PD-L1 in tissues were detected by immunohistochemistry method, the influencing factors of PD-1 and PD-L1 and correlation were analysed, the influencing factors of prognosis were analysed by Logistic regression analysis, the correlation between p65, PD-1, PD-L1 and prognosis was analysed. Results: The positive rates of p65, PD-1 and PD-L1 in NSCLC tissues were higher than in normal control tissues(P＜0.05). TNM stage, differentiation extent, lymph node metastasis, expression of p65 were influencing factors of expressions of PD-1 and PD-L1 (P＜0.05). The correlation analysis showed that p65 was positively correlated with PD-1 and PD-L1(P＜0.05). The prognosis of NSCLC patients were independently associated with TNM stage, differentiation extent, lymph node metastasis, expression of p65, PD-1 and PD-L1(P＜0.05). The overall survival(OS) of negative expression patients of p65, PD-1 and PD-L1 was longer than positive expression patients (P＜0.05). Conclusion: The expression of NF-κB p65 was closely correlated with PD-1 and PD-L1, and the expression of p65, PD-1 and PD-L1 had superior predictive value for prognosis of NSCLC patients. |
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