| 燕建锋,姚 娟,高 洁,方 舒,袁 杰.血清NEP、PTX3及H-FABP在慢性心力衰竭的表达水平及与疾病的相关性分析[J].,2023,(2):309-312 |
| 血清NEP、PTX3及H-FABP在慢性心力衰竭的表达水平及与疾病的相关性分析 |
| Expression Level of Serum NEP, PTX3, and H-FABP in Chronic Heart Failure and Its Correlation with Disease |
| 投稿时间：2022-05-22 修订日期：2022-06-17 |
| DOI：10.13241/j.cnki.pmb.2023.02.020 |
| 中文关键词: 慢性心力衰竭 NEP PTX3 H-FABP |
| 英文关键词: Chronic heart failure NEP PTX3 H-FABP |
| 基金项目:新疆维吾尔自治区自然科学基金项目（2017D01C114） |
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| 中文摘要: |
| 摘要 目的：探讨血清脑啡肽酶（NEP）、正五聚蛋白3（PTX3）及心型脂肪酸结合蛋白（H-FABP）在慢性心力衰竭（CHF）的表达水平及其与疾病严重程度的相关性。方法：选入我院2019年10月~2021年10月收治的110例CHF患者作为观察组，并根据美国纽约心脏病学会（NYHA）标准进行心功能分级，另取同期健康志愿者50例作为对照组。比较两组之间、观察组不同心功能分级之间的血清NEP、PTX3及H-FABP的表达水平，并分析三者与CHF严重程度的相关性。出院后随访90 d，记录主要心脏不良事件（MACE）情况。结果：观察组血清NEP和LVEF水平明显低于对照组（P＜0.05），而PTX3、H-FABP及LVEDD显著高于对照组（P＜0.05）；且随着NYHA分级升高，NEP和LVEF逐渐降低（P＜0.05），PTX3、H-FABP及LVEDD逐渐提高（P＜0.05），各组间差异显著（P＜0.05）；相关性分析结果显示：PTX3、H-FABP与NYHA分级和LVEDD存在明显正相关（P<0.05），与LVEF呈明显负相关（P<0.05），NEP与NYHA分级、LVEF和LVEDD均无明显相关性（P＞0.05）。MACE患者血清NEP水平显著低于非MACE患者，血清PTX3和H-FABP水平显著高于非MACE患者，差异有显著意义（P＜0.05）。结论：血清NEP、PTX3和H-FABP均是CHF诊断的重要生物学标志物，尤其是PTX3和H-FABP与病情严重程度和预后存在密切关系，联合检测对CHF早期诊断、病情和预后评估具有重要意义。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression levels of serum enkephalinase (NEP), pentamerin 3 (PTX3) and heart-type fatty acid-binding protein (H-FABP) in chronic heart failure (CHF) and their correlation with disease severity. Methods: 110 patients with CHF Treated in our hospital from October 2019 to October 2021 were selected as the observation group, and their cardiac function was graded according to the standards of New York Heart Association (NYHA), and 50 healthy volunteers in the same period were selected as the control group. The expression levels of serum nep, PTX3 and H-FABP between the two groups and the observation group were compared, and the correlation between them and the severity of CHF was analyzed. The patients were followed up for 90 days after discharge, and the main adverse cardiac events (MACE) were recorded. Results: The levels of serum NEP and LVEF in the observation group were significantly lower than those in the control group (P<0.05), while PTX3, H-FABP and LVEDd were significantly higher than those in the control group(P<0.05). With the increase of NYHA grade, nep and LVEF decreased gradually(P<0.05), while PTX3, H-FABP and LVEDd increased gradually (P<0.05); The results of correlation analysis showed that PTX3 and H-FABP were significantly positively correlated with NYHA grade and LVEDd (P<0.05), negatively correlated with LVEF (P<0.05), and NEP was not significantly correlated with NYHA grade, LVEF and LVEDd (P>0.05). The levels of serum NEP in mace patients were significantly lower than those in non mace patients, and the levels of serum PTX3 and H-FABP were significantly higher than those in non mace patients (P<0.05). Conclusion: Serum nep, PTX3 and H-FABP are important biomarkers for the diagnosis of CHF. In particular, PTX3 and H-FABP are closely related to the severity and prognosis of CHF. Combined detection is of great significance for the early diagnosis, condition and prognosis evaluation of CHF. |
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