| 张凯歌,张燕子,陈 静,邢 斐,刘 茜.肺炎支原体肺炎患儿血清sB7-H3含量与细胞因子水平及病情严重程度的相关性研究[J].,2023,(1):127-131 |
| 肺炎支原体肺炎患儿血清sB7-H3含量与细胞因子水平及病情严重程度的相关性研究 |
| Study of Correlation of Serum sB7-H3 with Cytokines in Children with Mycoplasma Pneumoniae Pneumonia |
| 投稿时间：2022-04-06 修订日期：2022-04-28 |
| DOI：10.13241/j.cnki.pmb.2023.01.025 |
| 中文关键词: 肺炎支原体肺炎 可溶性共刺激分子B7-H3 细胞因子 相关性 |
| 英文关键词: Mycoplasma pneumoniae pneumonia Soluble co-stimulatory molecule B7-H3 Cytokines Correlation |
| 基金项目:陕西省科技厅自然科学基础研究项目（2021JM-259） |
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| 中文摘要: |
| 摘要 目的：研究肺炎支原体肺炎（mycoplasma pneumoniae pneumonia, MPP）患儿血清可溶性共刺激分子B7-H3（soluble co-stimulatory molecule B7-H3, sB7-H3）含量与细胞因子水平及病情严重程度的相关性。方法：收集2019年3月至2020年6月期间我院收治的MPP患儿共96例，根据患儿病情严重程度分为轻症MPP组和重症MPP组，另选取同期于我院体检中心体检的健康儿童50例作为对照组。收集所有受试者的一般资料、主要临床表现、临床指标及细胞因子水平，对各指标进行Pearson相关性分析和多元逐步回归分析。结果：与对照组相比，MPP组患儿的白细胞计数（white blood cell, WBC）、中性粒细胞计数（neutrophil, NE）、红细胞沉降率（erythrocyta sedimentation rate, ESR）、C反应蛋白（C-reactive protein,CRP）、sB7-H3、粒细胞-巨噬细胞集落刺激因子（granulocyte-macrophage colony stimulating factor, GM-CSF）、干扰素-γ（interferon-γ, IFN-γ）、白介素-10（interleukin-10，IL-10）和白介素-17A（interleukin-17A，IL-17A）均较高（P＜0.05）；与轻症MPP组患儿相比，重症MPP组患儿的WBC、NE、ESR、CRP、sB7-H3、GM-CSF、IFN-γ、IL-10和IL-17A均较高（P＜0.05）。Pearson相关性分析结果表明，sB7-H3与WBC、NE、ESR、CRP、GM-CSF、IFN-γ、IL-10和IL-17A呈正相关（P＜0.05）。多元线性回归分析显示，GM-CSF（β=0.103，P＜0.001）、IFN-γ（β=0.121，P＜0.001）、IL-10（β=0.026，P＜0.001）和IL-17A（β=0.093，P＜0.001）是sB7-H3的独立影响因素。结论：MPP患儿血清sB7-H3、GM-CSF、IFN-γ、IL-10和IL-17A与MPP的病情严重程度密切相关，且sB7-H3的表达水平与GM-CSF、IFN-γ、IL-10和IL-17A的水平呈正相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation of serum soluble co-stimulatory molecule B7-H3(sB7-H3) with cytokines and severity of disease in children with mycoplasma pneumoniae pneumonia(MPP). Methods: 96 children with MPP admitted to our hospital from March 2019 to June 2020 were divived into mild MPP group and severe MPP group according to the disease condition, 50 healthy children were collected as control group in addition. The general information, main clinical manifestations, clinical indicators and cytokine levels of all subjects were collected, and Pearson correlation analysis and multiple stepwise regression analysis were performed on each indicator. Results: As compared with control group, the expression levels of white blood cell(WBC), neutrophil(NE), erythrocyta sedimentation rate(ESR), C-reactive protein(CRP), sB7-H3, granulocyte-macrophage colony stimulating factor(GM-CSF), interferon-γ(IFN-γ), interleukin-10(IL-10) and interleukin-17A(IL-17A) were higher(P＜0.05); and the expression levels of WBC, NE, ESR, CRP, sB7-H3, GM-CSF, IFN-γ, IL-10 and IL-17A of severe MPP group were higher than mild MPP group(P＜0.05). The correlation analysis showed that the expression levels of sB7-H3 was positively correlated with WBC, NE, ESR, CRP, GM-CSF, IFN-γ, IL-10 and IL-17A (P＜0.05), multiple linear regression analysis showed that the expression levels of sB7-H3 was independently associated with GM-CSF(β=0.103, P＜0.001), IFN-γ(β=0.121, P＜0.001), IL-10(β=0.026, P＜0.001) and IL-17A(β=0.093, P＜0.001). Conclusion: The serum sB7-H3, GM-CSF, IFN-γ, IL-10 and IL-17A were closely correlated with disease condition in children with MPP, and the expression level of sB7-H3 was positively correlated with GM-CSF, IFN-γ, IL-10 and IL-17A. |
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