| 张 彦,肖卫东,王 竞,杨越秀,金 丽.血清白细胞介素6、脑源性神经营养因子、甘油三酯、5-羟色胺与精神分裂症患者认知功能和攻击行为的关系分析[J].,2023,(1):52-57 |
| 血清白细胞介素6、脑源性神经营养因子、甘油三酯、5-羟色胺与精神分裂症患者认知功能和攻击行为的关系分析 |
| Relationship Analysis between Serum Interleukin-6, Brain-Derived Neurotrophic Factor, Triglycerides, 5-Hydroxytryptamine and Cognitive Function and Aggressive Behavior in Patients with Schizophrenia |
| 投稿时间：2022-07-18 修订日期：2022-08-15 |
| DOI：10.13241/j.cnki.pmb.2023.01.010 |
| 中文关键词: 精神分裂症 白细胞介素6 脑源性神经营养因子 甘油三酯 5-羟色胺 认知功能 攻击行为 影响因素 |
| 英文关键词: Schizophrenia Interleukin 6 Brain-derived neurotrophic factor Triglycerides 5-hydroxytryptamine Cognitive function Aggressive behavior Influencing factors |
| 基金项目:湖北省自然科学基金项目（2014CFB732） |
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| 中文摘要: |
| 摘要 目的：探讨血清白细胞介素6（IL-6）、脑源性神经营养因子（BDNF）、甘油三酯（TG）、5-羟色胺（5-HT）与精神分裂症（SZ）患者认知功能的关系，并分析SZ患者攻击行为的影响因素，研究血清IL-6、TG、BDNF、5-HT与攻击行为的关系。方法：选取2020年1月～2022年1月我院收治的112例SZ患者作为SZ组，根据有无攻击行为分为有攻击行为组31例和无攻击行为组81例，另选取同期41例体检健康者作为对照组，检测血清IL-6、BDNF、TG、5-HT水平，中文版MATRICS共识认知成套测验（MCCB）评估认知功能。采用Pearson/Spearman相关性分析SZ患者血清IL-6、BDNF、TG、5-HT水平与MCCB评分的相关性，多因素Logistic回归分析SZ患者攻击行为的影响因素，受试者工作特征（ROC）曲线分析血清IL-6、BDNF、TG、5-HT水平对SZ患者攻击行为的预测价值。结果：SZ组血清IL-6、TG水平高于对照组，BDNF、5-HT水平和MCCB评分低于对照组（P＜0.05）。Pearson/Spearman相关性分析显示，SZ患者血清IL-6、TG水平与MCCB评分呈负相关（r/rs=-0.569、-0.528，均P＜0.001），BDNF、5-HT水平与MCCB评分呈正相关（r/rs=0.587、0.602，均P＜0.001）。多因素Logistic回归分析显示，PANSS总分增加（OR=1.958，95％CI：1.035～3.704）、IL-6升高（OR=1.015，95％CI：1.041～1.172）、TG升高（OR=1.007，95％CI：1.023～1.135）为SZ患者攻击行为的独立危险因素，MCCB评分增加（OR=0.911，95％CI：0.848～0.979）、BDNF升高（OR=0.792，95％CI：0.656～0.955）、5-HT升高（OR=0.979，95％CI：0.965～0.994）为独立保护因素（均P＜0.05）。ROC曲线分析发现，血清IL-6、BDNF、TG、5-HT水平单独与联合预测SZ患者攻击行为的曲线下面积（AUC）分别为0.765、0.754、0.750、0.748、0.920，四项联合预测SZ患者攻击行为的AUC大于各指标单独预测。结论：SZ患者血清IL-6、TG水平升高和BDNF、5-HT水平降低与认知功能障碍和攻击行为有关，血清IL-6、BDNF、TG、5-HT水平可作为SZ患者攻击行为的辅助预测指标。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the relationship between serum interleukin-6 (IL-6), brain-derived neurotrophic factor (BDNF), triglycerides (TG), 5-hydroxytryptamine (5-HT) and cognitive function in patients with schizophrenia (SZ), and to analyze the influencing factors of aggressive behavior in patients with SZ, and to study the relationship between serum IL-6, TG, BDNF, 5-HT and aggressive behavior. Methods: 112 patients with SZ who were admitted to our hospital from January 2020 to January 2022 were selected as SZ group, they were divided into aggressive behavior group with 31 cases and non-aggressive behavior group with 81 cases according to whether they had aggressive behavior. 41 healthy physical examination people in the same period were selected as the control group. The levels of serum IL-6, BDNF, TG and 5-HT were measured, and the cognitive function was evaluated by the MATRICS Consensus Cognitive Battery (MCCB). Pearson/spearman correlation was used to analyze the correlation between the levels of serum IL-6, BDNF, TG, 5-HT and MCCB score in patients with SZ. Multivariate logistic regression was used to analyze the influencing factors of aggressive behavior in patients with SZ. Receiver operating characteristic(ROC) curve was used to analyze the predictive value of the levels of serum IL-6, BDNF, TG, 5-HT on aggressive behavior in patients with SZ. Results: The levels of serum IL-6 and TG in the SZ group were higher than those in the control group, while the levels of BDNF, 5-HT and MCCB score were lower than those in the control group (P<0.05). Pearson/Spearman correlation analysis showed that the levels of serum IL-6 and TG in patients with SZ were negatively correlated with MCCB score (r/rs=-0.569, -0.528, all P<0.001), while the levels of BDNF and 5-HT were positively correlated with MCCB score (r/rs=0.587, 0.602, all P<0.001). Multivariate Logistic regression analysis showed that the total score of PANSS increased (OR=1.958, 95%CI: 1.035～3.704), IL-6 increased (OR=1.015, 95%CI: 1.041～1.172), TG increased (OR=1.007, 95%CI: 1.023～1.135) were the independent risk factor for aggressive behavior in patients with SZ, with MCCB score increased (OR=0.911, 95%CI: 0.848～0.979) and BDNF increased (OR=0.792, 95%CI: 0.656～0.955) and 5-HT increased (OR=0.979, 95%CI: 0.965～0.994) were independent protective factors (all P<0.05). ROC curve analysis showed that the area under the curve (AUC) of serum IL-6, BDNF, TG and 5-HT levels alone and in combination to predict aggressive behavior in patients with SZ were 0.765, 0.754, 0.750, 0.748 and 0.920, respectively. The AUC of the four combined to predict aggressive behavior in patients with SZ was greater than that of each index alone. Conclusion: The increased levels of serum IL-6 and TG and decreased levels of BDNF and 5-HT in patients with SZ are associated with cognitive dysfunction and aggressive behavior. Serum levels of IL-6, BDNF, TG and 5-HT can be used as auxiliary predictors of aggressive behavior in patients with SZ. |
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