| 李雪龙,于剑锋,王燕斌,张东磊,刘 晓.血清sCD44v6、HLA-G、G-17、Hp-IgG联合检测在胃癌与癌前病变筛查中的临床价值探讨[J].,2022,(22):4258-4262 |
| 血清sCD44v6、HLA-G、G-17、Hp-IgG联合检测在胃癌与癌前病变筛查中的临床价值探讨 |
| Discussion on the Clinical Value of Serum sCD44v6, HLA-G, G-17 and Hp-IgG Combined Detection in Screening Gastric Cancer and Precancerous Lesions |
| 投稿时间：2022-06-20 修订日期：2022-07-15 |
| DOI：10.13241/j.cnki.pmb.2022.22.011 |
| 中文关键词: 胃癌 癌前病变 sCD44v6 HLA-G G-17 Hp-IgG 筛查 |
| 英文关键词: Gastric cancer Precancerous lesions sCD44v6 HLA-G G-17 Hp-IgG Screening |
| 基金项目:北京市科技计划首都临床特色应用研究与成果推广项目（Z171100001017054） |
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| 中文摘要: |
| 摘要 目的：探讨血清可溶性CD44变体6（sCD44v6）、人类白细胞抗原-G（HLA-G）、胃泌素-17（G-17）、幽门螺杆菌-免疫球蛋白G（Hp-IgG）联合检测在胃癌与癌前病变筛查中的临床价值。方法：选择2019年2月至2022年2月期间首都医科大学附属北京朝阳医院消化内科收治的121例胃癌癌前病变患者（癌前病变组）和125例胃癌患者（胃癌组），另选择同期120例健康体检者作为对照组，检测并比较三组间血清sCD44v6、HLA-G、G-17水平以及Hp-IgG阳性率。根据Hp-IgG阳性情况，将胃癌组进一步分为Hp-IgG阳性组与Hp-IgG阴性组，比较两组间血清sCD44v6、HLA-G、G-17水平。应用Spearman秩相关分析胃癌组血清sCD44v6、HLA-G、G-17水平与Hp-IgG阳性率的相关性，应用受试者工作特征（ROC）曲线分析sCD44v6、HLA-G、G-17、Hp-IgG单独鉴别和联合四项指标鉴别胃癌癌前病变与胃癌的价值。结果：胃癌组血清sCD44v6、HLA-G、G-17水平以及Hp-IgG阳性率高于癌前病变组、对照组（P＜0.05），癌前病变组血清sCD44v6、HLA-G、G-17水平以及Hp-IgG阳性率高于对照组（P＜0.05），胃癌组中Hp-IgG阳性组sCD44v6、HLA-G、G-17水平高于Hp-IgG阴性组（P＜0.05）。胃癌组血清sCD44v6、HLA-G、G-17水平与Hp-IgG阳性率呈正相关（rs=0.536、0.492、0.512，P＜0.05）。联合sCD44v6、HLA-G、G-17、Hp-IgG鉴别胃癌癌前病变以及胃癌的曲线下面积为0.863，高于各指标单独鉴别。结论：血清sCD44v6、HLA-G、G-17水平以及Hp-IgG阳性率在胃癌患者与胃癌癌前病变患者中存在明显差异，胃癌患者血清sCD44v6、HLA-G、G-17水平与Hp-IgG阳性有关，联合四项指标检测在胃癌与癌前病变筛查中具有较高的临床价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical value of serum soluble CD44 variant 6 (sCD44v6), human leukocyte antigen G (HLA-G), gastrin-17 (G-17) and Helicobacter pylori immunoglobulin G (Hp-IgG) combined detection in the screening of gastric cancer and precancerous lesions. Methods: 121 patients with precancerous lesions of gastric cancer (precancerous lesions group) and 125 patients with gastric cancer (gastric cancer group) who were treated in the Department of Gastroenterology, Beijing Chaoyang Hospital Affiliated to Capital Medical University from February 2019 to February 2022 were selected, and 120 healthy people in the same period were selected as the control group, the levels of serum sCD44v6, HLA-G, G-17 and the positive rate of Hp-IgG were detected and compared among the three groups. According to the positive status of Hp-IgG, the gastric cancer group was further divided into Hp-IgG positive group and Hp-IgG negative group, the levels of serum sCD44v6, HLA-G and G-17 were compared between the two groups. Spearman rank correlation analysis was conducted to analyze the correlation between serum sCD44v6, HLA-G, G-17 levels and the positive rate of Hp-IgG in patients with gastric cancer, and receiver operating characteristic (ROC) curve was used to analyze the value of sCD44v6, HLA-G, G-17 and Hp-IgG alone or in combination in differentiating precancerous lesions and gastric cancer. Results: The levels of serum sCD44v6, HLA-G and G-17 and the positive rate of Hp-IgG in gastric cancer group were higher than those in precancerous lesion group and control group (P<0.05). The levels of serum sCD44v6, HLA-G and G-17 and the positive rate of Hp-IgG in precancerous lesion group were higher than those in control group (P<0.05). The levels of sCD44v6, HLA-G and G-17 in Hp-IgG-positive group were higher than those in Hp-IgG-negative group (P<0.05). The levels of serum sCD44v6, HLA-G and G-17 were positively correlated with the positive rate of Hp-IgG in gastric cancer group (rs=0.536, 0.492, 0.512, P<0.05). The area under the curve of combining sCD44v6, HLA-G, G-17 and Hp-IgG in the identification of gastric cancer precancerous lesions and gastric cancer was 0.863, which was higher than that of 0.620, 0.672, 0.600 and 0.673 respectively. Conclusion: The levels of serum sCD44v6, HLA-G, G-17 and the positive rate of Hp-IgG in patients with gastric cancer are significantly different from those with precancerous lesions of gastric cancer. The levels of serum sCD44v6, HLA-G, G-17 in patients with gastric cancer were related to the positive rate of Hp-IgG. The combined detection of four indexes has high clinical value in the screening of gastric cancer and precancerous lesions. |
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