| 徐维慧,张 彬,马 玲,邹 晖,杨欢欢,孙 坚.不同病情严重程度急性脑梗死患者肠道屏障功能指标、炎性指标的变化及临床意义[J].,2022,(21):4153-4156 |
| 不同病情严重程度急性脑梗死患者肠道屏障功能指标、炎性指标的变化及临床意义 |
| Changes and Clinical Significance of Intestinal Barrier Function Indexes and Inflammatory Indexes in Patients with Acute Cerebral Infarction with Different Severity of Disease |
| 投稿时间：2022-04-23 修订日期：2022-05-18 |
| DOI：10.13241/j.cnki.pmb.2022.21.028 |
| 中文关键词: 急性脑梗死 肠道屏障功能 炎性指标 病情严重程度 相关性 |
| 英文关键词: Acute cerebral infarction Intestinal barrier function Inflammatory indicators Severity of disease Correlation |
| 基金项目:江苏省自然科学基金项目（BK20170385）；南通市科技局科技项目（HS2020001） |
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| 中文摘要: |
| 摘要 目的：探讨不同病情严重程度急性脑梗死（ACI）患者肠道屏障功能指标、炎性指标的变化及临床意义。方法：选择2020年7月至2021年8月我院收治的ACI患者80例为病例组，根据病情严重程度分为轻症组（62例）和重症组（18例），另选择同期在我院健康体检者60例为对照组。检测所有受试者的肠道屏障功能指标[内毒素（ET）、D-乳酸（D-LA）、二胺氧化酶（DAO）]和炎性指标[白细胞计数（WBC）、中性粒细胞百分比（NEU%）、C反应蛋白（CRP）、降钙素原（PCT）]水平，对比病例组与对照组、轻症组与重症组上述指标水平差异，并分析上述指标水平与病情严重程度的相关性。结果：病例组的ET、D-LA、DAO及WBC、NEU%、CRP、PCT水平均高于对照组（P＜0.05）；重症组的ET、D-LA、DAO及WBC、NEU%、CRP、PCT水平均高于轻症组（P＜0.05）；ACI患者的ET、D-LA、DAO及WBC、NEU%、CRP、PCT水平与病情严重程度呈正相关（P＜0.05）。结论：ACI患者肠道屏障功能指标、炎性指标水平异常增高，增高程度与患者病情严重程度呈正相关，早期检测肠道屏障功能指标、炎性指标有助于ACI病情判断，可为临床治疗提供一定参考依据。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the changes and clinical significance of intestinal barrier function indexes and inflammatory indexes in patients with acute cerebral infarction (ACI) with different severity of disease. Methods: 80 patients with ACI who were treated in our hospital from July 2020 to August 2021 were selected as the case group, they were divided into mild group (62 cases) and severe group (18 cases) according to the severity of disease, and 60 healthy persons who underwent physical examination in our hospital in the same period were selected as the control group. The levels of intestinal barrier function indexes [endotoxin (ET), D-lactic acid (D-LA), diamine oxidase (DAO)] and inflammatory indexes [white blood cell count (WBC), percentage of neutrophils (NEU%), C-reactive protein (CRP) and procalcitonin (PCT)] were measured in all subjects. The differences of the above indexes between case group and control group, mild group and severe group were compared, and the correlation between the above indexes and the severity of disease was analyzed. Results:: The levels of ET, D-LA, DAO, WBC, NEU%, CRP and PCT in the case group were higher than those in the control group (P＜0.05). The levels of ET, D-LA, DAO, WBC, NEU%, CRP and PCT in severe group were higher than those in mild group (P＜0.05). The levels of ET, D-LA, DAO, WBC, NEU%, CRP and PCT in patients with ACI were positively correlated with the severity of disease (P＜0.05). Conclusion: The levels of intestinal barrier function indexes and inflammatory indexes in patients with ACI are abnormally increased, and the degree of increase is positively correlated with the patient's severity of disease. Early detection of intestinal barrier function indexes and inflammatory indexes is helpful to judge the condition of ACI, and which can provide a certain reference basis for clinical treatment. |
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