| 费朝霞,李 红,丁明罡,韩 洁,张作仕.2型糖尿病患者血清尿酸、胱抑素C、半乳糖凝集素-3、丝氨酸蛋白酶抑制剂B1与血糖及颈动脉粥样硬化的关系研究[J].,2022,(20):3951-3955 |
| 2型糖尿病患者血清尿酸、胱抑素C、半乳糖凝集素-3、丝氨酸蛋白酶抑制剂B1与血糖及颈动脉粥样硬化的关系研究 |
| Study on the Relationship between Serum Uric Acid, Cystatin C, Galactose Lectin 3 and Serine Protease Inhibitor B1 and Blood Glucose and Carotid Atherosclerosis in Patients with Type 2 Diabetic Mellitus |
| 投稿时间：2022-03-23 修订日期：2022-04-18 |
| DOI：10.13241/j.cnki.pmb.2022.20.030 |
| 中文关键词: 2型糖尿病 尿酸 胱抑素C 半乳糖凝集素-3 丝氨酸蛋白酶抑制剂B1 血糖 |
| 英文关键词: Type 2 diabetes mellitus Uric acid Cystatin C Galectin 3 Serine protease inhibitor B1 Blood glucose |
| 基金项目:山东省医药卫生科技发展项目(202104130109） |
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| 中文摘要: |
| 摘要 目的：研究2型糖尿病（T2DM）患者血清尿酸（UA）、胱抑素C（CysC）、半乳糖凝集素-3（Gal-3）、丝氨酸蛋白酶抑制剂B1（Serpin B1）与血糖及颈动脉粥样硬化（CAS）的关系。方法：选取2020年4月-2022年4月青岛市中医医院内分泌科收治的110例T2DM患者，根据有无CAS分为CAS组36例和非CAS组74例，检测并对比两组血清UA、CysC、Gal-3、Serpin B1水平。通过Pearson/Spearman相关系数分析T2DM患者血清UA、CysC、Gal3、Serpin B1水平与血糖指标的相关性。收集患者基础资料，采用多因素Logistic回归分析T2DM患者发生CAS的影响因素。结果：CAS组血清UA、CysC、Gal-3、Serpin B1水平均明显高于非CAS组（P＜0.05）。CAS组平均年龄大于非CAS组，吸烟史患者比例、空腹血糖、糖化血红蛋白（HbA1c）、胰岛素抵抗指数（HOMA-IR）、低密度脂蛋白胆固醇（LDL-C）水平高于非CAS组（P＜0.05）。相关性分析显示，T2DM患者血清UA、CysC、Gal-3、Serpin B1水平与HbA1c、HOMA-IR呈正相关（P＜0.05）。多因素Logistic回归分析显示，年龄较大、HbA1c、HOMA-IR、血清UA、CysC、Gal3、Serpin B1水平较高是T2DM患者发生CAS的危险因素（P＜0.05）。结论：血清UA、CysC、Gal-3、Serpin B1水平升高与T2DM患者血糖水平有关，同时也是T2DM患者发生CAS的影响因素。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between serum uric acid (UA), cystatin C (CysC), galectin 3 (Gal-3), serine protease inhibitor B1 (Serpin B1) and blood glucose and carotid atherosclerosis (CAS) in patients with type 2 diabetes mellitus (T2DM). Methods: 110 patients with T2DM who were treated in the Department of Endocrinology of Qingdao Hospital of Traditional Chinese Medicine from April 2020 to April 2022 selected, and they were divided into 36 cases in CAS group and 74 cases in non CAS group according to the presence or absence of CAS. The levels of serum UA, CysC, Gal-3 and Serpin B1 were detected and compared between the two groups. Pearson/Spearman correlation coefficient was used to analyze the correlation between the levels of serum UA, CysC, Gal3, Serpin B1 and blood glucose indexes in patients with T2DM. The basic data of patients were collected, and the influencing factors of CAS in patients with T2DM were analyzed by multivariate Logistic regression. Results: The levels of serum UA, CysC, Gal-3 and Serpin B1 in CAS group were significantly higher than those in non CAS group (P<0.05). The average age of CAS group was higher than that of non CAS group, and the proportion of patients with smoking history, fasting blood glucose, glycosylated hemoglobin (HbA1c), insulin resistance index (HOMA-IR) and low density lipoprotein cholesterol (LDL-C) were higher than those in non CAS group (P<0.05). Correlation analysis showed that the levels of serum UA, CysC, Gal-3 and Serpin B1 in patients with T2DM were positively correlated with HbA1c and HOMA-IR (P<0.05). Multivariate Logistic regression analysis showed that older age, higher levels of HbA1c, HOMA-IR, serum UA, CysC, Gal3 and Serpin B1 were the risk factors of CAS in patients with T2DM (P<0.05). Conclusion: Elevated levels of serum UA, CysC, Gal3 and Serpin B1 are closely associated with blood glucose level of patients with T2DM, and it is also the influencing factor of CAS in patients with T2DM. |
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