| 郭 鑫,林曼霞,旦慧文,于 佳,丁树颜,朱 萍.血清VEGF-A、sHLA-G、Syndecan-1水平与子宫内膜异位症患者疾病分期和痛经程度的相关性及其联合检测的诊断价值研究[J].,2022,(20):3892-3896 |
| 血清VEGF-A、sHLA-G、Syndecan-1水平与子宫内膜异位症患者疾病分期和痛经程度的相关性及其联合检测的诊断价值研究 |
| The Correlation between the Levels of Serum VEGF-A, sHLA-G, Syndecan-1 and Disease Stages and Dysmenorrhea Degree in Patients with Endometriosis and the Diagnostic Value Study of its Combined Detection |
| 投稿时间：2022-03-28 修订日期：2022-04-24 |
| DOI：10.13241/j.cnki.pmb.2022.20.018 |
| 中文关键词: 子宫内膜异位症 VEGF-A sHLA-G Syndecan-1 疾病分期 痛经程度 诊断价值 |
| 英文关键词: Endometriosis VEGF-A sHLA-G Syndecan-1 Disease stage Dysmenorrhea degree Diagnostic value |
| 基金项目:山东省自然科学基金项目（ZR2017MH1108） |
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| 中文摘要: |
| 摘要 目的：探讨血清血管内皮生长因子-A（VEGF-A）、可溶性人类白细胞抗原-G（sHLA-G）、多配体蛋白多糖-1（Syndecan-1）水平与子宫内膜异位症（EMS）患者疾病分期和痛经程度的相关性及其联合检测的诊断价值。方法：选取2018年1月～2021年12月我院收治的120例EMS患者作为观察组，另取同期女性健康体检者120例作为对照组。检测并比较两组血清VEGF-A、sHLA-G、Syndecan-1水平。此外，分别对比不同疾病分期、不同痛经程度EMS患者上述三项指标水平的差异。采用Spearman相关系数分析血清VEGF-A、sHLA-G、Syndecan-1水平与疾病分期、痛经程度的相关性。以受试者工作特征（ROC）曲线分析上述三项指标联合检测对EMS的诊断效能。结果：观察组血清VEGF-A、sHLA-G、Syndecan-1水平均高于对照组（P＜0.05）。R-AFS分期为Ⅲ～Ⅳ期的EMS患者其血清VEGF-A、sHLA-G、Syndecan-1水平均高于Ⅰ～Ⅱ期患者（P＜0.05）。痛经程度为中度和重度的EMS患者其血清VEGF-A、sHLA-G、Syndecan-1水平均高于轻度痛经患者，且重度痛经患者上述指标水平均高于中度痛经患者（P＜0.05）。Spearman相关性分析结果显示：EMS患者的血清VEGF-A、sHLA-G、Syndecan-1水平与疾病分期、痛经程度均呈正相关（P＜0.05）。ROC曲线分析结果显示：血清VEGF-A、sHLA-G、Syndecan-1联合检测诊断EMS的曲线下面积为0.894，明显高于三指标单独检测。结论：EMS患者血清VEGF-A、sHLA-G、Syndecan-1均存在异常高表达，且和疾病分期以及痛经程度有关，可能有助于临床EMS诊断及病情评估。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between the levels of serum vascular endothelial growth factor-A (VEGF-A), soluble human leukocyte antigen-G (sHLA-G), Syndecan-1 and the disease stages and dysmenorrhea degree in patients with endometriosis (EMS) and the diagnostic value of its combined detection. Methods: 120 patients with EMS who were treated in our hospital from January 2018 to December 2021 were selected as the observation group, and 120 female physical examiners in the same period were selected as the control group. The levels of serum VEGF-A, sHLA-G and Syndecan-1 were detected and compared between the two groups. In addition, the differences of the above three indexes in patients with EMS with different disease stages and different dysmenorrhea degree were compared. Spearman correlation coefficient was used to analyze the correlation between the levels of serum VEGF-A, sHLA-G and Syndecan-1 and disease stage and dysmenorrhea degree. Using receiver operating characteristic (ROC) curve to analyze the diagnostic efficiency of the above three indexes in the combined detection of EMS. Results: The levels of serum VEGF-A, sHLA-G and Syndecan-1 in the observation group were higher than those in the control group (P＜0.05). The levels of serum VEGF-A, sHLA-G and Syndecan-1 in patients with EMS with R-AFS stage Ⅲ～Ⅳ were higher than those in patients with stage Ⅰ～Ⅱ (P＜0.05). The levels of serum VEGF-A, sHLA-G and Syndecan-1 in patients with EMS with moderate and severe dysmenorrhea were higher than those in patients with mild dysmenorrhea, and the levels of the above indexes in patients with severe dysmenorrhea were higher than those in patients with moderate dysmenorrhea (P＜0.05). Spearman correlation analysis showed that the levels of serum VEGF-A, sHLA-G and Syndecan-1 in patients with EMS were positively correlated with disease stage and dysmenorrhea degree (P＜0.05). ROC curve analysis showed that the area under the curve of serum VEGF-A, sHLA-G and Syndecan-1 in the diagnosis of EMS was 0.894, which was significantly higher than that of the three indexes alone. Conclusion: Serum VEGF-A, sHLA-G and Syndecan-1 in patients with EMS have abnormally high expression, which is related to disease stage and dysmenorrhea degree, which may be helpful for clinical EMS diagnosis and condition evaluation. |
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