| 于利雅,彭 蕾,罗 婷,黄陈程,王兆霞.帕金森病患者睡眠障碍与脑电图活动、神经心理学指标和健康相关生活质量的关系研究[J].,2022,(20):3863-3867 |
| 帕金森病患者睡眠障碍与脑电图活动、神经心理学指标和健康相关生活质量的关系研究 |
| Relationship Study between Sleep Disorders and EEG Activity, Neuropsychological Indicators and Health-Related Quality of Life in Patients with Parkinson's Disease |
| 投稿时间：2022-04-19 修订日期：2022-05-15 |
| DOI：10.13241/j.cnki.pmb.2022.20.012 |
| 中文关键词: 帕金森病 睡眠障碍 脑电图活动 神经心理学 健康相关生活质量 |
| 英文关键词: Parkinson's disease Sleep disorders EEG activity Neuropsychology Health-related quality of life |
| 基金项目:江苏省卫生厅科研基金项目（2016013517） |
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| 摘要 目的：研究帕金森病（PD）患者睡眠障碍与脑电图活动、神经心理学指标和健康相关生活质量的关系。方法：选择我院2018年5月～2021年5月收治100例PD患者。将其根据匹兹堡睡眠质量指数（PSQI）评分的差异分作睡眠障碍组（PSQI评分＞7分）68例及无睡眠障碍组（PSQI评分≤7分）32例。比较两组脑电图活动、神经心理学指标以及39项帕金森病生活质量调查表（PDQ39）评分，并分析PSQI评分与脑电图活动、神经心理学指标及PDQ39评分的相关性。结果：睡眠障碍组的δ波和θ波相对功率值高于无睡眠障碍组，而β1、β2两个频段的相对功率值低于无睡眠障碍组（P＜0.05）；睡眠障碍组脑电图轻度异常、中度异常以及重度异常的患者比例高于无睡眠障碍组，而脑电图正常的患者比例低于无睡眠障碍组（P＜0.05）。睡眠障碍组蒙特利尔认知评估中文量表（MoCA）评分低于无睡眠障碍组，而汉密尔顿焦虑量表（HAMA）、汉密尔顿抑郁量表（HAMD）评分均高于无睡眠障碍组（P＜0.05）。睡眠障碍组PDQ39各项目评分及总分均高于无睡眠障碍组（P＜0.05）。经Pearson及Spearman相关性分析可得：PD患者的PSQI评分与脑电图异常程度、HAMA评分、HAMD评分及PDQ39评分均呈正相关，而与MoCA评分呈负相关（P＜0.05）。结论：睡眠障碍可能对PD患者认知功能造成损害，加剧焦虑、抑郁等负性情绪，并降低其健康相关生活质量，监测脑电图活动可在一定程度上判断PD患者睡眠障碍严重程度。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between sleep disorders and EEG activity, neuropsychological indicators and health-related quality of life in patients with Parkinson's disease (PD). Methods: 100 patients with PD who were treated in our hospital from May 2018 to May 2021 were selected. According to the difference of Pittsburgh sleep Quality Index (PSQI) score, 68 patients were divided into sleep disorder group (PSQI score > 7 scores), and 32 cases were divided into non sleep disorder group (PSQI score ≤ 7 scores). EEG activity, neuropsychological indicators and 39 Parkinson's disease Quality of Life Questionnaire (PDQ39) scores were compared between the two groups, and the correlation between PSQI score and EEG activity, neuropsychological indicators and PDQ39 score were analyzed. Results: The relative power values of δ wave and θ wave in the sleep disorder group were higher than those in the non sleep disorder group, while the relative power values of β1 and β2 bands were lower than those in the non sleep disorder group (P＜0.05). The proportion of patients with mild abnormal, moderate abnormal and severe abnormal EEG in sleep disorder group were higher than that in the non sleep disorder group, while the proportion of patients with normal EEG was lower than that in the non sleep disorder group (P＜0.05). The scores of Montreal Cognitive Assessment Chinese Scale (MoCA) in the sleep disorder group were lower than those in the non sleep disorder group, while the scores of Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) were higher than those in the non sleep disorder group (P＜0.05). The scores and total scores of PDQ39 items in the sleep disorder group were higher than those in the non sleep disorder group (P＜0.05). Pearson and Spearman correlation analysis showed that PSQI score of patients with PD was positively correlated with EGG abnormal, HAMA score, HAMD score and PDQ39 score, but negatively correlated with MoCA score (P＜0.05). Conclusion: Sleep disorder may damage cognitive function of patients with PD, aggravate negative emotions such as anxiety and depression, and reduce their health-related quality of life. Monitoring EEG activity can judge the severity of sleep disorder in patients with PD to a certain extent. |
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