| 赵小燕,张 伟,王晋平,郭 飞,张 倩.术前修正衰弱指数联合C反应蛋白/白蛋白比值、中性粒细胞/淋巴细胞比值对老年结直肠癌患者术后谵妄发生风险的评估价值[J].,2022,(19):3735-3739 |
| 术前修正衰弱指数联合C反应蛋白/白蛋白比值、中性粒细胞/淋巴细胞比值对老年结直肠癌患者术后谵妄发生风险的评估价值 |
| Evaluation Value of Preoperative Modified Frailty Index Combined with C-Reactive Protein/Albumin Ratio and Neutrophil Lymphocyte Ratio on the Risk of Postoperative Delirium in Elderly Patients with Colorectal Cancer |
| 投稿时间：2022-02-28 修订日期：2022-03-23 |
| DOI：10.13241/j.cnki.pmb.2022.19.026 |
| 中文关键词: 老年 结直肠癌 谵妄 修正衰弱指数 CAR NLR |
| 英文关键词: Elderly Colorectal cancer Delirium Modified frailty index CAR NLR |
| 基金项目:河南省医学科技攻关项目（201503037） |
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| 中文摘要: |
| 摘要 目的：探讨术前修正衰弱指数（mFI）联合C反应蛋白/白蛋白比值（CAR）、中性粒细胞/淋巴细胞比值（NLR）预测老年结直肠癌患者术后谵妄发生风险的价值。方法：选择2020年1月至2021年12月郑州大学第一附属医院收治的352例行腹腔镜手术治疗的老年结直肠癌患者，根据术后谵妄发生情况将患者分为谵妄组（63例）和无谵妄组（289例）。术前采用mFI评估衰弱状态，检测C反应蛋白、白蛋白、中性粒细胞计数和淋巴细胞计数，计算CAR和NLR。分析影响老年结直肠癌患者术后发生谵妄的危险因素以及mFI、CAR和NLR预测老年结直肠癌患者术后发生谵妄的价值。结果：谵妄组mFI、CAR、NLR大于无谵妄组（P＜0.05）。年龄、饮酒史、脑血管病史、精神病史、术后转重症监护病房（ICU）比例高于无谵妄组（P＜0.05）。年龄、mFI、CAR、NLR升高是老年结直肠癌患者术后发生谵妄的危险因素（P＜0.05）。联合mFI、CAR、NLR预测老年结直肠癌患者术后发生谵妄的曲线下面积为0.835，高于单独mFI、CAR、NLR预测的0.688、0.741、0.733。结论：mFI、CAR、NLR升高是老年结直肠癌患者术后发生谵妄的危险因素，三指标联合检测有助于评估老年结直肠癌患者术后发生谵妄的风险。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the value of preoperative modified frailty index (mFI) combined with C-reactive protein/albumin ratio (CAR) and neutrophil/lymphocyte ratio (NLR) in predicting postoperative delirium in elderly patients with colorectal cancer. Methods: 352 elderly patients with colorectal cancer who underwent laparoscopic surgery in The First Affiliated Hospital of Zhengzhou University from January 2020 to December 2021 were selected. According to the occurrence of postoperative delirium, the patients were divided into delirium group (63 cases) and non delirium group (289 cases). Before operation, mFI was used to evaluate the delirium state, C-reactive protein, albumin, neutrophil count and lymphocyte count were detected, and CAR and NLR were calculated. The risk factors of postoperative delirium in elderly patients with colorectal cancer and the value of mFI, CAR and NLR in predicting postoperative delirium in elderly patients with colorectal cancer were analyzed. Results: The mFI, CAR and NLR in delirium group were higher than those in non delirium group (P＜0.05), and the proportion of age, drinking history, cerebrovascular history, psychiatric history and postoperative transfer to intensive care unit (ICU) were higher than those in non delirium group (P＜0.05). Age, mFI, CAR and NLR increased were risk factors for postoperative delirium in elderly patients with colorectal cancer (P＜0.05). The area under curve of combining mFI, CAR and NLR to predict postoperative delirium in elderly patients with colorectal cancer was 0.835, which was higher than 0.688, 0.741 and 0.733 predicted by mFI, CAR and NLR alone. Conclusion: The increase of mFI, CAR and NLR are risk factors for postoperative delirium in elderly patients with colorectal cancer, combined detection of the three indicators is helpful to evaluate the risk of postoperative delirium in elderly patients with colorectal cancer. |
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