| 赵子涵,于 潇,刘鹏飞,王 丽,刘金星.多囊卵巢综合征不孕患者性激素水平与免疫失衡及胰岛素抵抗指数的关系研究[J].,2022,(19):3680-3683 |
| 多囊卵巢综合征不孕患者性激素水平与免疫失衡及胰岛素抵抗指数的关系研究 |
| Relationship Study between Sex Hormone Level, Immune Imbalance and Insulin Resistance Index in Infertile Patients with Polycystic Ovary Syndrome |
| 投稿时间：2022-03-24 修订日期：2022-04-21 |
| DOI：10.13241/j.cnki.pmb.2022.19.015 |
| 中文关键词: 多囊卵巢综合征 不孕 性激素 免疫失衡 胰岛素抵抗 |
| 英文关键词: Polycystic ovary syndrome Infertility Sex hormone Immune imbalance Insulin resistance |
| 基金项目:山东省自然科学基金项目（ZR2019PH053） |
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| 中文摘要: |
| 摘要 目的：探讨多囊卵巢综合征（PCOS）不孕患者性激素水平与免疫失衡及胰岛素抵抗指数的关系。方法：选取2019年1月～2021年12月于山东中医药大学附属医院就诊的88例PCOS不孕患者作为研究组，同期选取健康体检女性80例作为对照组。检测比较两组的性激素、Th1/Th2免疫相关指标以及稳态模型胰岛素抵抗指数（HOMA-IR），采用Pearson相关系数分析PCOS不孕患者性激素与Th1/Th2、HOMA-IR的相关性。结果：研究组的血清黄体生成素（LH）、雌二醇（E2）、睾酮（T）水平及LH/FSH比值均明显高于对照组，而促卵泡激素（FSH）水平低于对照组（P＜0.05）。研究组的外周血干扰素-γ（IFN-γ）水平、Th1细胞比例及Th1/Th2比值均明显高于对照组（P＜0.05），而两组间白细胞介素-4（IL-4）水平和Th2细胞比例无显著差异（P＞0.05）。研究组的空腹血糖（FPG）、空腹胰岛素（FINS）水平及HOMA-IR均明显高于对照组（P＜0.05）。Pearson相关性分析结果显示，PCOS不孕患者的E2、T水平、LH/FSH比值与Th1/Th2比值、HOMA-IR均呈正相关（P＜0.05）。结论：PCOS不孕患者存在胰岛素抵抗及免疫失衡，且胰岛素抵抗、免疫失衡与其性激素表达有关。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the relationship between sex hormone level, immune imbalance and insulin resistance index in infertile patients with polycystic ovary syndrome. Methods: 88 infertile patients with PCOS who were treated in our hospital from January 2019 to December 2021 were selected as the study group, and 80 healthy women were selected as the control group in the same period. The sex hormones, Th1/Th2 immune related indexes and homeostasis model insulin resistance index (HOMA-IR) were detected and compared between the two groups. The correlation between sex hormones and Th1/Th2, HOMA-IR in infertile patients with PCOS was analyzed by Pearson correlation coefficient. Results: The serum luteinizing hormone (LH), estradiol (E2), testosterone (T) and LH/FSH ratio in the study group were significantly higher than those in the control group, while the follicle stimulating hormone (FSH) level was lower than that in the control group (P＜0.05). The interferon -γ (IFN-γ) level, Th1 cell ratio and Th1/Th2 ratio in peripheral blood in the study group were significantly higher than those in the control group (P＜0.05), but there were no significant differences in interleukin-4 (IL-4) level and Th2 cell ratio between the two groups(P>0.05). The fasting plasma glucose (FPG), fasting insulin (FINS) levels and HOMA-IR in the study group were significantly higher than those in the control group(P＜0.05). Pearson correlation analysis showed that E2, T levels, LH/FSH ratio, Th1/Th2 ratio and HOMA-IR were positively correlated in infertile patients with PCOS(P＜0.05). Conclusion: The infertility patients with PCOS have insulin resistance and immune imbalance, and insulin resistance and immune imbalance are related to the expression of sex hormones. |
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