| 高玉宝,吴伟伟,朋源凤,姜天鑫,李 飞.通督调神针刺法联合胞磷胆碱对脑梗死后血管性痴呆患者认知功能、血液流变学和脑血流动力学的影响[J].,2022,(17):3347-3350 |
| 通督调神针刺法联合胞磷胆碱对脑梗死后血管性痴呆患者认知功能、血液流变学和脑血流动力学的影响 |
| Effects of Tongdu Tiaoshen Acupuncture Combined with Citicoline on Cognitive Function, Hemorheology and Cerebral Hemodynamics in Patients with Vascular Dementia after Cerebral Infarction |
| 投稿时间：2022-03-09 修订日期：2022-03-31 |
| DOI：10.13241/j.cnki.pmb.2022.17.029 |
| 中文关键词: 通督调神针刺法 胞磷胆碱 脑梗死后血管性痴呆 认知功能 血液流变学 脑血流动力学 |
| 英文关键词: Tongdu tiaosheng acupuncture Citicoline Vascular dementia after cerebral infarction Cognitive function Hemorheology Cerebral hemodynamics |
| 基金项目:国家自然科学基金项目（81001558） |
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| 中文摘要: |
| 摘要 目的：观察通督调神针刺法联合胞磷胆碱对脑梗死后血管性痴呆（VD）患者认知功能、血液流变学和脑血流动力学的影响。方法：选择2018年3月～2021年3月期间安徽中医药大学第二附属医院收治的98例脑梗死后VD患者，采用随机数字表法分为对照组（49例，胞磷胆碱联合传统针刺治疗）和观察组（49例，通督调神针刺法联合胞磷胆碱治疗）。对比两组疗效、认知功能、痴呆症状、日常生活能力、血液流变学和脑血流动力学。结果：观察组的临床总有效率高于对照组（P<0.05）。治疗后，观察组日常活动能力量表（ADL）、长谷川痴呆修正量表（HDS-R）、简易智力状态检查量表（MMSE）评分高于对照组（P<0.05）；观察组血细胞比容、血浆黏度、全血高切黏度、全血低切黏度低于对照组（P<0.05）；观察组收缩期峰值速度（Vmax）、搏动指数（PI）高于对照组；舒张期峰值速度（Vmin）、阻力指数（RI）低于对照组（P<0.05）。结论：胞磷胆碱联合通督调神针刺法治疗脑梗死后VD，可促进其痴呆症状、认知功能和日常生活能力改善，可能与调节血液流变学和脑血流动力学有关。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of Tongdu Tiaoshen acupuncture combined with citicoline on cognitive function, hemorheology and cerebral hemodynamics in patients with vascular dementia (VD) after cerebral infarction. Methods: 98 cases of VD after cerebral infarction who were treated in The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine from March 2018 to March 2021 were selected. They were randomly divided into control group (49 cases, citicoline combined with traditional acupuncture) and observation group (49 cases, Tongdu Tiaoshen acupuncture combined with citicoline). The efficacy, cognitive function, dementia symptoms, activities of daily living, hemorheology and cerebral hemodynamics were compared between the two groups. Results: The total clinical effective rate of the observation group was higher than that of the control group (P<0.05). After treatment, the scores of a ctivity of Daily Living Scale (ADL) and hasegawa dementia correction scale (HDS-R), mini-Mental State Examination (MMSE) in the observation group were higher than those of the control group (P<0.05). The hematocrit, plasma viscosity, whole blood high shear viscosity and whole blood low shear viscosity in the observation group was lower than those of the control group (P<0.05). The peak systolic velocity (Vmax) and pulsatility index (PI) in the observation group were higher than those of the control group. The peak diastolic velocity (Vmin) and resistance index (RI) were lower than those of the control group (P<0.05). Conclusion: Citicolinecombined with Tongdu Tiaoshen acupuncture are effective in the treatment of patients with VD after cerebral infarction. It can improve dementia symptoms, cognitive function and activities of daily living, which may be related to the regulation of hemorheology and cerebral hemodynamics. |
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