| 王莎莎,Jorge A. Trujillo Perdomo,薛 敏,潘 荣,史春生.和血明目片联合全视网膜激光光凝术对糖尿病视网膜病变患者视力状况、血液流变学及脉络膜厚度的影响[J].,2022,(17):3343-3346 |
| 和血明目片联合全视网膜激光光凝术对糖尿病视网膜病变患者视力状况、血液流变学及脉络膜厚度的影响 |
| Effects of Hexuemingmu Tablet Combined with Whole Retina Laser Photocoagulation on Visual Acuity, Hemorheology and Choroidal Thickness in Patients with Diabetes Retinopathy |
| 投稿时间：2022-03-08 修订日期：2022-03-30 |
| DOI：10.13241/j.cnki.pmb.2022.17.028 |
| 中文关键词: 和血明目片 全视网膜激光光凝术 糖尿病视网膜病变 视力状况 血液流变学 脉络膜厚度 |
| 英文关键词: Hexuemingmu tablet Whole retina laser photocoagulation Diabetes retinopathy Visual acuity Hemorheology Choroidal thickness |
| 基金项目:2021 年度安徽省卫生健康委科研项目（AHWJ2021b107） |
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| 中文摘要: |
| 摘要 目的：探讨和血明目片联合全视网膜激光光凝术（PRP）对糖尿病视网膜病变（DR）患者视力状况、血液流变学及脉络膜厚度的影响。方法：选择2018年3月~2019年12月期间来安徽省第二人民医院接受治疗的60例DR患者，经计算机随机编号按奇偶顺序分为对照组（奇数，n=30）和研究组（偶数，n=30），两组在接受常规降糖治疗的基础上，对照组患者接受PRP治疗，研究组患者接受和血明目片联合PRP治疗，对比两组临床总有效率，观察两组治疗前后的视力状况、血液流变学及脉络膜厚度变化。结果：研究组的临床总有效率高于对照组（P<0.05）。治疗后，两组裸眼视力、视野、视敏度均升高，研究组的升高程度大于对照组（P<0.05）。治疗后，两组血浆黏度（PV）、红细胞聚集指数（AI）、全血高切黏度（NBH）、全血低切黏度（NBL）、血沉（ESR）均下降，研究组的下降程度大于对照组（P<0.05）。治疗后，两组黄斑中心凹下脉络膜厚度（SFCT）、下方脉络膜厚度（ICT）、上方脉络膜厚度（SCT）、鼻侧脉络膜厚度（NCT）、颞侧脉络膜厚度（TCT）均下降，研究组的下降程度大于对照组（P<0.05）。两组均未见明显的不良反应发生。结论：和血明目片联合PRP可有效改善DR患者的视力状况、血液流变学及脉络膜厚度。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of hexuemingmu tablet combined with whole retina laser photocoagulation (PRP) on visual acuity, hemorheology and choroidal thickness in patients with diabetes retinopathy (DR). Methods: 60 patients with DR who received treatment in Anhui No.2 Provincial People's Hospital from March 2018 to December 2019 were selected, and they were randomly numbered by computer and divided into control group (odd, n=30) and study group (even, n=30) in odd-even order. On the basis of conventional hypoglycemic treatment for the two groups, the control group received PRP treatment. The patients in the study group received hexuemingmu tablet combined with PRP treatment. The total clinical response rate of the two groups was compared, and the changes of visual acuity, hemorheology and choroid thickness were observed before and after treatment. Results: The total clinical effective rate in the study group was higher than that in the control group (P<0.05). After treatment, naked eye vision, visual field and visual acuity were increased in two groups, and the degree of increase in the study group was greater than that in the control group (P<0.05). After treatment, plasma viscosity (PV), erythrocyte aggregation index (AI), whole blood high shear viscosity (NBH), whole blood low shear viscosity (NBL) and erythrocyte sedimentation rate (ESR) decreased in two groups, and the decrease degree in the study group was greater than that in the control group (P<0.05). After treatment, the inferior choroid thickness (SFCT), inferior choroid thickness (ICT), superior choroid thickness (SCT), nasal choroid thickness (NCT) and temporal choroid thickness (TCT) in the macular fovea decreased in two groups, and the decrease degree in the study group was greater than that in the control group (P<0.05). There were no obvious adverse reactions in two groups. Conclusion: Hexuemingmu tablet combined with PRP can effectively improve the visual acuity, hemorheology and choroidal thickness of patients with DR, and the curative effect is safe and reliable. |
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