| 徐 良,叶长青,王 静,徐海波,邵先安.银杏叶提取物注射液联合单硝酸异山梨酯对经桡动脉穿刺冠脉介入后桡动脉闭塞和血流动力学的影响[J].,2022,(16):3148-3152 |
| 银杏叶提取物注射液联合单硝酸异山梨酯对经桡动脉穿刺冠脉介入后桡动脉闭塞和血流动力学的影响 |
| Effects of Ginkgo Biloba Extract Injection Combined with Isosorbide Mononitrate on Radial Artery Occlusion and Hemodynamics after Percutaneous Coronary Intervention |
| 投稿时间：2022-02-06 修订日期：2022-02-28 |
| DOI：10.13241/j.cnki.pmb.2022.16.030 |
| 中文关键词: 银杏叶提取物注射液 单硝酸异山梨酯 桡动脉穿刺 冠脉介入 桡动脉闭塞 血流动力学 |
| 英文关键词: Ginkgo biloba extract injection Isosorbide mononitrate Radial artery puncture Coronary intervention Radial artery occlusion Hemodynamics |
| 基金项目:安徽省卫生计生委科研计划项目（2016QK0217） |
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| 中文摘要: |
| 摘要 目的：探究银杏叶提取物注射液联合单硝酸异山梨酯对经桡动脉穿刺冠脉介入后桡动脉闭塞（RAO）和血流动力学的影响。方法：选取2020年1月～2021年1月我院收治的120例经桡动脉穿刺冠脉介入患者为研究对象，使用随机数字表法分为观察组（n=59，单硝酸异山梨酯治疗）与对照组（n=61，对照组基础上联合银杏叶提取物注射液治疗）。探究两组患者术后7 d时、术后30 d时、术后3个月时RAO发生情况差异，比较两组患者治疗前、治疗2周后血流动力学指标[收缩期峰速度(PSV)、舒张末期速度（EDV）、阻力指数（RI）]差异，比较两组患者治疗前、治疗30 d后心功能[B型脑钠肽（BNP）、左室射血分数（LVEF）、心脏指数（CI）]差异，分析两组患者不良反应差异。结果：术后7 d时，观察组患者RAO发生低于对照组（P＜0.05），术后30 d时、术后3个月时，两组患者RAO发生率差异均不显著（P均＞0.05）；治疗2周后，两组患者PSV、EDV水平均较治疗前上升，RI水平均较治疗前下降，且观察组PSV、EDV高于对照组，RI低于对照组（P均＜0.05）；治疗30 d后，两组患者BNP较治疗前均降低，且观察组BNP低于对照组，两组患者LVEF、CI均较治疗前上升，且观察组LVEF、CI高于对照组（P均＜0.05）；两组患者不良反应发生差异均不显著（P均＞0.05）。结论：银杏叶提取物注射液联合单硝酸异山梨酯可减少经桡动脉穿刺冠脉介入后RAO发生，对患者血流动力学影响更小，有利于患者心功能恢复，安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of Ginkgo biloba extract injection combined with isosorbide mononitrate on radial artery occlusion (RAO) and hemodynamics after percutaneous coronary intervention. Methods: 120 patients with percutaneous coronary intervention through radial artery in our hospital from January 2020 to January 2021 were selected as the research objects, they were randomly divided into observation group (n=59, isosorbide mononitrate treatment) and control group (n=61, control group combined with Ginkgo biloba extract injection). The differences of RAO between the two groups at 7 d, 30 d and 3 months after operation were explored, the differences of hemodynamic indexes [peak systolic velocity (PSV), end diastolic velocity (EDV) and resistance index (RI)] between the two groups before and 2 weeks after treatment were compared, and the differences of cardiac function [B-type brain natriuretic peptide (BNP), left ventricular ejection fraction (LVEF) and cardiac index (CI)] between the two groups before and 30d after treatment were compared, the difference of adverse reactions between the two groups was analyzed. Results: The incidence of RAO in the observation group was lower than that in the control group at 7 d after operation (P<0.05). There was no significant difference in the incidence of RAO between the two groups at 30d after operation and 3 months after operation (all P>0.05). 2 weeks after treatment, the levels of PSV and EDV in the two groups were higher than those before treatment, and the level of RI was lower than that before treatment. Moreover, the PSV and EDV in the observation group were higher than those in the control group, and the RI was lower than that in the control group (all P<0.05). 30 d after treatment, BNP in the two groups was lower than that before treatment, BNP in the observation group was lower than that in the control group, LVEF and CI in the two groups were higher than those before treatment, and LVEF and CI in the observation group were higher than those in the control group (all P<0.05). There was no significant difference in adverse reactions between the two groups (all P>0.05). Conclusion: Ginkgo biloba extract injection combined with isosorbide mononitrate can reduce the occurrence of RAO after coronary intervention through radial artery puncture, which have less impact on hemodynamics, and it is conducive to the recovery of cardiac function, and with a good safety. |
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