| 俞志松,阮发晖,吴 轲,林庚海,杨 鹏,张旺东,戴增欢.急性心肌梗死患者血清Myo、Cat S、NGAL与PCI术后炎症因子和住院期间主要不良心血管事件的关系研究[J].,2022,(16):3102-3106 |
| 急性心肌梗死患者血清Myo、Cat S、NGAL与PCI术后炎症因子和住院期间主要不良心血管事件的关系研究 |
| Relationship Study between Serum Myo, Cat S, NGAL and Inflammatory Factors after PCI and Major Adverse Cardiovascular Events During Hospitalization in Patients with Acute Myocardial Infarction |
| 投稿时间：2022-02-06 修订日期：2022-02-28 |
| DOI：10.13241/j.cnki.pmb.2022.16.021 |
| 中文关键词: 急性心肌梗死 Myo Cat S NGAL PCI 炎症因子 不良心血管事件 |
| 英文关键词: Acute myocardial infarction Myo Cat S NGAL PCI Inflammatory factors Adverse cardiovascular events |
| 基金项目:福建省自然科学基金项目（2015J05129） |
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| 中文摘要: |
| 摘要 目的：探讨急性心肌梗死（AMI）患者血清肌红蛋白（Myo）、组织蛋白酶S（Cat S）、中性粒细胞明胶酶相关载脂蛋白（NGAL）与经皮冠状动脉介入治疗术（PCI）后炎症因子和住院期间主要不良心血管事件（MACE）的关系。方法：选择我院2020年3月~2021年11月期间接收的行PCI术的AMI患者126例，根据术后是否发生MACE分为MACE组和非MACE组。对比非MACE组、MACE组血清Myo、Cat S、NGAL水平和白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、白介素-10（IL-10）水平。采用Pearson检验分析Myo、Cat S、NGAL与炎性因子的相关性，采用多因素Logistic回归分析患者住院期间发生MACE的影响因素。结果：住院期间，126例患者中有34例患者发生MACE，其余92例未发生MACE，发生率为26.98%。MACE 组的血清Myo、Cat S、NGAL水平高于非MACE组（P<0.05）。MACE组的血清IL-6、TNF-α高于非MACE组，IL-10水平低于非MACE组（P<0.05）。Pearson检验分析结果显示，Myo、Cat S、NGAL与IL-6、TNF-α呈正相关，而与IL-10呈负相关（P<0.05）。单因素分析结果显示，非MACE组、MACE组在年龄、发病-就诊时间、糖化血红蛋白（HbAlc）、N末端B型利钠肽原（NT-proBNP）、Killp分级≥Ⅱ级方面对比有统计学差异（P<0.05）。多因素Logistic回归分析结果显示：Myo偏高、Cat S偏高、NGAL偏高、HbAlc偏高、NT-proBNP偏高、Killp分级≥Ⅱ级是发生MACE的影响因素（P<0.05）。结论：MACE患者体内Myo、Cat S、NGAL异常升高，且与炎症因子水平相关。Myo、Cat S、NGAL、HbAlc、NT-proBNP、Killp分级≥Ⅱ级均是发生MACE的影响因素。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum myoglobin (Myo), cathepsin S (Cat S), neutrophil gelatinase associated apolipoprotein (NGAL) and inflammatory factors after percutaneous coronary intervention and major adverse cardiovascular events (MACE) during hospitalization in patients with acute myocardial infarction (AMI). Methods: 126 patients with AMI who underwent PCI in our hospital from March 2020 to November 2021 were selected. They were divided into MACE group and non MACE group according to whether MACE occurred after operation. The levels of serum Myo, Cat S, NGAL, interleukin-6 (IL-6) and tumor necrosis factor- α (TNF-α) and interleukin-10 (IL-10) in non MACE group and MACE group were compared. Pearson test was used to analyze the correlation between Myo, Cat S, NGAL and inflammatory factors. Multivariate Logistic regression was used to analyze the influencing factors of MACE during hospitalization. Results: During hospitalization, 34 cases of 126 patients developed MACE, and the remaining 92 patients did not develop MACE, with an incidence of 26.98%. The serum levels of Myo, Cat S and NGAL in MACE group were higher than those in non MACE group(P<0.05). Serum IL-6 and TNF-α in MACE group were higher than those in non-MACE group, the level of IL-10 was lower than that in non mace group(P<0.05). Pearson test analysis showed that Myo, Cat S, NGAL were positively correlated with IL-6 and TNF-α, while negatively correlated with IL-10 (P<0.05). Univariate analysis showed that there were significant differences between non MACE group and MACE group in age, onset-visit time, glycosylated hemoglobin (HbAlc), N-terminal B-type natriuretic peptide(NT-proBNP) and Killp grade ≥ grade II(P<0.05). Multivariate Logistic regression analysis showed that high Myo, high Cat S, high NGAL, high HbAlc, high NT-proBNP and Killp grade ≥ grade II were the influencing factors of MACE (P<0.05). Conclusion: The levels of Myo, Cat S and NGAL in patients with MACE are abnormally elevated, and correlated with the levels of inflammatory factors. Myo, Cat S, NGAL, HbAlc, NT-probNP and Killp grade ≥ grade II are the influencing factors of MACE. |
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