| 王志杰,郑建英,赵晓佩,孟昭君,王思田,李天琪.速效牙痛宁酊辅助根管治疗对慢性牙髓炎患者口腔健康相关生活质量和血清Toll样受体4、CX3C趋化因子配体1的影响[J].,2022,(14):2773-2777 |
| 速效牙痛宁酊辅助根管治疗对慢性牙髓炎患者口腔健康相关生活质量和血清Toll样受体4、CX3C趋化因子配体1的影响 |
| Effects of Quick Acting Yatongning Tincture Assisted Root Canal Therapy on Oral Health-Related Quality of Life and Serum Toll Like Receptor 4 and CX3C Chemokine Ligand 1 in Patients with Chronic Pulpitis |
| 投稿时间：2022-01-28 修订日期：2022-02-23 |
| DOI：10.13241/j.cnki.pmb.2022.14.035 |
| 中文关键词: 速效牙痛宁酊 根管治疗 慢性牙髓炎 生活质量 Toll样受体4 CX3C趋化因子配体1 |
| 英文关键词: Quick acting yatongning tincture Root canal therapy Chronic pulpitis Quality of life Toll like receptor 4 CX3C chemokine ligand 1 |
| 基金项目:河北省卫生厅科研基金项目（20170050）；2019年衡水市科技计划项目（2019014047Z） |
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| 中文摘要: |
| 摘要 目的：观察速效牙痛宁酊辅助根管治疗对慢性牙髓炎患者口腔健康相关生活质量和血清CX3C趋化因子配体1（CX3CL1）、Toll样受体4（TLR4）的影响。方法：选取衡水市中医院2019年9月~2021年6月期间收治的87例慢性牙髓炎患者（患牙87颗），根据随机数字表法分为观察组44例（患牙44颗，给予速效牙痛宁酊辅助根管治疗）、对照组43例（患牙43颗，给予根管治疗）。对比两组临床疗效，观察两组疼痛症状和口腔健康相关生活质量改善情况，比较两组血清TLR4、CX3CL1水平变化，并记录两组不良反应发生情况。结果：观察组的临床总有效率高于对照组（P<0.05）。治疗2周后、4周后，两组视觉模拟量表（VAS）评分降低，且观察组较对照组低（P<0.05）。治疗4周后，两组口腔健康影响程度量表（OHIP-14）各领域（社交障碍、心理障碍、功能限制、生理障碍、残障、生理疼痛、心理不适）评分及总分降低，且观察组低于对照组（P<0.05）。治疗4周后，两组血清CX3CL1、TLR4水平下降，观察组较对照组低（P<0.05）。与对照组比较，观察组并发症总发生率较低（P<0.05）。结论：速效牙痛宁酊辅助根管治疗慢性牙髓炎患者，可有效减轻疼痛症状，提高口腔健康相关生活质量，作用机制可能与调节血清TLR4、CX3CL1水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of quick acting yatongning tincture assisted root canal therapy on oral health-related quality of life and serum CX3C chemokine ligand 1 (CX3CL1) and toll like receptor 4 (TLR4) in patients with chronic pulpitis. Methods: 87 patients with chronic pulpitis (87 teeth) who were treated in Hengshui Hospital of Traditional Chinese Medicine from September 2019 to June 2021 were selected, and they were randomly divided into 44 cases in the observation group (44 teeth with root canal treatment assisted by quick acting yatongning tincture) and 43 cases in the control group (43 teeth were treated with root canal therapy) by random number table method. The clinical effects of the two groups were compared, the improvement of pain symptoms and oral health-related quality of life in the two groups were observed, the changes of serum TLR4 and CX3CL1 levels in the two groups were compared, and the occurrence of adverse reactions in the two groups were recorded. Results: The total clinical effective rate of the observation group was higher than that of the control group (P<0.05). 2 weeks and 4 weeks after treatment, the scores of visual analogue scale (VAS) in the two groups decreased, and the observation group was lower than the control group (P<0.05). 4 weeks after treatment, the oral health impact scale (OHIP-14) (social disorder, psychological disorder, functional restriction, physiological disorder, disability, physiological pain and psychological discomfort) scores and total score in the two groups decreased, and the observation group was lower than the control group (P<0.05). 4 weeks after treatment, the serum CX3CL1 and TLR4 levels of the two groups decreased, and the observation group was lower than the control group (P<0.05). Compared with the control group, the total incidence of complication in the observation group was lower (P<0.05). Conclusion: Quick acting yatongning tincture assisted root canal therapy in patients with chronic pulpitis can effectively reduce pain symptoms and improve oral health-related quality of life. The mechanism may be related to regulating the serum TLR4 and CX3CL1 levels. |
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