| 于养生,吕惠惠,丛 超,张文芳,刘 秀.急性ST段抬高型心肌梗死介入手术时间窗与血清FGF21水平的相关性[J].,2022,(12):2347-2351 |
| 急性ST段抬高型心肌梗死介入手术时间窗与血清FGF21水平的相关性 |
| Correlation between the Time Window of Interventional Surgery for Acute ST-segment Elevation Myocardial Infarction and Serum FGF21 Levels |
| 投稿时间：2021-11-02 修订日期：2021-11-26 |
| DOI：10.13241/j.cnki.pmb.2022.12.030 |
| 中文关键词: 手术时间窗 急性ST段抬高型心肌梗死 成纤维细胞生长因子21 |
| 英文关键词: Operating window Acute ST-segment elevation myocardial infarction Fibroblast growth factor 21 |
| 基金项目:山东省中医药科技发展计划项目(2019-0509） |
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| 中文摘要: |
| 摘要 目的：探讨急性ST段抬高型心肌梗死介入手术时间窗与血清成纤维细胞生长因子21（FGF21）水平的相关性。方法：选择本院2019年1月-2021年1月收治的急性ST段抬高型心肌梗死患者120例作为研究对象，根据随机1：1抽签法把患者分为研究组与对照组各60例。所有患者都给予急诊经皮冠脉介入手术治疗，对照组在发病后7-12 h进行介入治疗，研究组在发病后≤6 h进行介入治疗，检测、记录血清FGF21表达变化情况并进行相关性分析。结果：两组治疗后1周的血清心肌肌钙蛋白T（cTnT）、心肌肌钙蛋白Ⅰ（cTnⅠ）含量低于治疗前，研究组低于对照组（P<0.05）。两组治疗后1周的血清FGF21水平高于治疗前，研究组高于对照组（P<0.05）。治疗后随访6个月，研究组的心律失常、心力衰竭、心绞痛、心源性休克等不良心血管事件发生率为3.3 %，低于对照组的26.7 %（P<0.05）。在两组120例患者中，发病后≤6 h进行介入治疗为影响患者治疗后血清FGF21水平、近期疗效与随访不良心血管事件的重要因素（P<0.05）。结论：发病后≤6 h介入治疗急性ST段抬高型心肌梗死可促进血清FGF21的释放，提高治疗近期疗效，改善心功能，也可降低远期不良心血管事件的发生，介入手术时间窗与血清FGF21的表达存在相关性。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between the time window of interventional surgery for acute ST-segment elevation myocardial infarction and serum fibroblast growth factor 21 (FGF21) levels. Methods: From January 2019 to January 2021, 120 cases of patients with acute ST-segment elevation myocardial infarction admitted to our hospital were selected as the research objects, and the patients were divided into research group and control group with 60 patients in each groups accorded to a random 1:1 lottery method. All patients were treated with emergency percutaneous coronary intervention. The control group were received interventional treatment 7-12 h after the onset of the disease, and the research group were received interventional treatment ≤6 h after the onset of the disease. The changes in serum FGF21 expression were detected and recorded and correlation analysis were performed. Results: The serum cardiac troponin T (cTnT) and cardiac troponin I (cTnⅠ) levels in the two groups were lower than before treatment, and the research group were lower than the control group (P<0.05). Serum FGF21 level 1 week after treatment in both groups was higher than that before treatment, and that in the study group was higher than that in the control group (P<0.05). Followed-up for 6 months after treatment, The incidence of adverse cardiovascular events such as arrhythmia, heart failure, angina, and cardiogenic shock in the research group were 3.3 %, which were lower than 26.7 % in the control group (P<0.05). In the two groups of 120 patients, interventional therapy ≤6 h after the onset of the disease were an important factor affecting the serum FGF21 level, short-term efficacy and follow-up adverse cardiovascular events (P<0.05). Conclusion: Interventional treatment of ACUTE ST-segment elevation myocardial infarction ≤6 h after onset can promote the release of serum FGF21, improve the short-term therapeutic effect, improve cardiac function, and reduce the occurrence of long-term adverse cardiovascular events. The time window of interventional surgery is correlated with the expression of serum FGF21. |
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