| 李 倩,赵彩霞,王荣华,卫敏超,马彩艳.早产儿血清炎性因子与生长发育指标的关系及对新生儿呼吸窘迫综合征的预测研究[J].,2022,(12):2342-2346 |
| 早产儿血清炎性因子与生长发育指标的关系及对新生儿呼吸窘迫综合征的预测研究 |
| Study on the Relationship between Serum Inflammatory Factors and Growth Indices in Premature Infants and the Prediction of Neonatal Respiratory Distress Syndrome |
| 投稿时间：2021-10-27 修订日期：2021-11-22 |
| DOI：10.13241/j.cnki.pmb.2022.12.029 |
| 中文关键词: 早产儿 炎性因子 生长发育 新生儿呼吸窘迫综合征 |
| 英文关键词: Premature infants Inflammatory factors Growth and development Neonatal respiratory distress syndrome |
| 基金项目:山西省重点研发计划项目（201803D31163） |
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| 中文摘要: |
| 摘要 目的：分析早产儿血清炎性因子与生长发育指标的关系及对新生儿呼吸窘迫综合征（RDS）的预测效能。方法：选择2018年1月至2020年10月在我院出生的98例早产儿作为研究对象，根据是否并发RDS，分为RDS组（58例）和非RDS组（40例）。检测两组血清白细胞介素-1β（IL-1β）、IL-6、IL-8、肿瘤坏死因子-α（TNF-α）、降钙素原（PCT）水平，记录生长发育指标，通过Pearson相关性分析早产儿血清炎性因子与生长发育指标的关系，使用受试者工作特征曲线（ROC）分析血清炎性因子对新生儿呼吸窘迫综合征的预测效能。结果：RDS组血清IL-1β、IL-6、IL-8、TNF-α、PCT水平均高于非RDS组（P＜0.05）；RDS组胎龄、出生体重均小于非RDS组（P＜0.05）；经Pearson相关性分析，早产儿血清IL-1β、IL-6、IL-8、TNF-α、PCT水平均与胎龄、出生体重呈负相关（P＜0.05）；经多因素Logistic回归分析，IL-1β、IL-6、IL-8、TNF-α、PCT均是早产儿并发新生儿呼吸窘迫综合征的独立危险因素（P＜0.05）；经ROC曲线分析，IL-1β、IL-6、IL-8、TNF-α联合PCT预测早产儿并发新生儿呼吸窘迫综合征的AUC为0.910。结论：早产儿血清IL-1β、IL-6、IL-8、TNF-α均与胎龄及出生体重密切相关，这些炎性因子联合预测RDS发生的效能较好，值得临床予以重视应用。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the relationship between serum inflammatory factors and growth indices in premature infants and the predictive efficacy of neonatal respiratory distress syndrome (RDS). Methods: A total of 98 premature infants born in our hospital from January 2018 to October 2020 were selected as the study subjects. According to the complications of RDS, they were divided into RDS group (58 cases) and non-RDS group (40 cases). Serum interleukin-1 β(IL-1β), IL-6, IL-8, tumor necrosis factor -α(TNF-α), procalcitonin (PCT) levels were detected in the two groups, and growth and development indicators were recorded.The relationship between serum inflammatory factors and growth and development indicators was analyzed by Pearson correlation analysis.Receiver operating characteristic curve (ROC) was used to analyze the predictive efficacy of serum inflammatory factors for neonatal respiratory distress syndrome. Results: The levels of IL-1β, IL-6, IL-8, TNF-α and PCT in RDS group were higher than those in non-RDS group (P<0.05). The gestational age and birth weight of RDS group were lower than those of non-RDS group (P<0.05). Pearson correlation analysis showed that serum LEVELS of IL-1β, IL-6, IL-8, TNF-α and PCT were negatively correlated with gestational age and birth weight (P<0.05). Multiple Logistic regression analysis showed that IL-1β, IL-6, IL-8, TNF-α and PCT were independent risk factors for neonatal respiratory distress syndrome in premature infants (P<0.05). ROC curve analysis showed that Il-1β, IL-6, IL-8 and TNF-α combined with PCT predicted the AUC of neonatal respiratory distress syndrome in premature infants was 0.910. Conclusion: Serum IL-1β, IL-6, IL-8 and TNF-α are closely correlated with gestational age and birth weight in premature infants. These inflammatory factors have good efficacy in predicting the occurrence of RDS, and deserve clinical attention. |
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