| 李 静,覃腊云,欧阳辉,吴 杰,章 婵.肺康复训练联合规律性有氧运动疗法对稳定期COPD患者心肺运动功能、生活质量和Th17/Treg细胞亚群失衡的影响[J].,2022,(12):2337-2341 |
| 肺康复训练联合规律性有氧运动疗法对稳定期COPD患者心肺运动功能、生活质量和Th17/Treg细胞亚群失衡的影响 |
| Effects of Lung Rehabilitation Training Combined with Regular Aerobic Exercise Therapy on Cardiopulmonary Motor Function, Quality of Life and Imbalance of Th17 / Treg Cell Subsets in Patients with Stable COPD |
| 投稿时间：2021-10-28 修订日期：2021-11-22 |
| DOI：10.13241/j.cnki.pmb.2022.12.028 |
| 中文关键词: 肺康复训练 有氧运动 稳定期慢性阻塞性肺疾病 心肺运动功能 生活质量 Th17/Treg细胞亚群 |
| 英文关键词: Pulmonary rehabilitation training Aerobic exercise Stable chronic obstructive pulmonary disease Cardiopulmonary motor function Quality of life Th17 / Treg cell subsets |
| 基金项目:湖南省中医药管理局科研计划项目（2013153） |
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| 中文摘要: |
| 摘要 目的：观察肺康复训练联合规律性有氧运动疗法对稳定期慢性阻塞性肺疾病（COPD）患者心肺运动功能、生活质量和Th17/Treg细胞亚群失衡的影响。方法：选取2019年6月-2021年6月期间于我院接受治疗的80例稳定期COPD患者，根据随机数字表法分为观察组（40例，肺康复训练联合规律性有氧运动疗法）、对照组（40例，接受肺康复训练），比较两组患者心肺运动功能、运动耐量、生活质量和Th17/Treg细胞亚群失衡相关指标。结果：两组干预3个月后最大分钟通气量（VEmax）、峰值摄氧量（PeakVO2）升高，且观察组高于对照组（P<0.05）。两组干预3个月后无氧阈时二氧化碳通气当量（VE/CO2 at AT）下降，且观察组低于对照组（P<0.05）。两组干预3个月后圣?乔治呼吸问卷（SGRQ）评分降低，且观察组低于对照组（P<0.05）。两组干预3个月后6 min步行试验（6MWT）距离、运动时间延长，且观察组长于对照组（P<0.05）。两组干预3个月后Treg含量升高，且观察组高于对照组（P<0.05）；两组干预3个月后Th17/Treg比值、Th17含量下降，且观察组低于对照组（P<0.05）。结论：肺康复训练联合规律性有氧运动疗法用于稳定期COPD患者，可改善其心肺运动功能，提高运动耐量，提高生活质量，同时还可调节Th17/Treg细胞亚群失衡。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of lung rehabilitation training combined with regular aerobic exercise therapy on cardiopulmonary motor function, quality of life and imbalance of Th17/Treg cell subsets in patients with stable chronic obstructive pulmonary disease (COPD). Methods: 80 patients with stable COPD who were treated in our hospital from June 2019 to June 2021 were selected, they were randomly divided into observation group (40 cases, lung rehabilitation training combined with regular aerobic exercise therapy) and control group (40 cases, receiving lung rehabilitation training). The cardiopulmonary motor function, exercise tolerance, quality of life and imbalance of Th17/Treg cell subsets were compared between the two groups. Results: 3 months after intervention, the maximum minute ventilation (VEmax) and peak oxygen uptake (PeakVO2) increased in the two groups, and the observation group was higher than the control group (P<0.05). 3 months after intervention, the carbon dioxide ventilation equivalent (VE/CO2 at AT) at anaerobic threshold decreased in the two groups, and the observation group was lower than the control group (P<0.05). 3 months after intervention, the score of St. George's Respiratory Questionnaire (SGRQ) decreased in the two group, the observation group was lower than the control group (P<0.05). 3 months after intervention, the 6-min walking test (6MWT) distance and exercise time were prolonged in the two groups, and the observation group was longer than the control group (P<0.05). Treg content in the two groups increased 3 months after intervention, and the observation group was higher than the control group (P<0.05). Th17/Treg ratio and Th17 content in the two groups decreased 3 months after intervention, and the observation group was lower than the control group (P<0.05). Conclusion: Lung rehabilitation training combined with regular aerobic exercise therapy in the treatment of patients with stable COPD can improve cardiopulmonary motor function, improve exercise tolerance, improve quality of life, and regulate the imbalance of Th17 / Treg cell subsets. |
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