| 李莲乔,黄倩蕾,齐 琦,田浴阳,王 香.血清IFN-γ、ESR以及sIL-2R在急性淋巴细胞白血病患儿中的表达水平与病情的相关性[J].,2022,(11):2176-2180 |
| 血清IFN-γ、ESR以及sIL-2R在急性淋巴细胞白血病患儿中的表达水平与病情的相关性 |
| Correlation between the Expression Levels of Serum IFN-γ, ESR and sIL-2R in Children with Acute Lymphoblastic Leukemia |
| 投稿时间：2021-12-04 修订日期：2021-12-27 |
| DOI：10.13241/j.cnki.pmb.2022.11.035 |
| 中文关键词: 急性淋巴细胞白血病 干扰素-γ 可溶性白细胞介素2受体 血沉 |
| 英文关键词: Acute lymphoblastic leukemia Interferon-γ Soluble interleukin 2 receptor Erythrocyte sedimentation rate |
| 基金项目:国家癌症中心攀登基金（NCC201808B026） |
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| 中文摘要: |
| 摘要 目的：探讨与分析血清干扰素-γ（IFN-γ）、血沉（ESR）以及可溶性白细胞介素2受体（sIL-2R）在急性淋巴细胞白血病（ALL）患儿中的表达水平与病情的相关性。方法：选择2017年2月到2020年10月在本院血液科诊治的急性淋巴细胞白血病患儿62例作为ALL组，同期选择在本院体检的健康小儿62例作为对照组，检测所有小儿的血清IFN-?酌、ESR、sIL-2R水平，判定ALL组患儿的免疫表型、染色体分析，随访患儿的预后并进行相关性分析。结果：ALL组的CD34+阳性、CD117+阳性、染色体核型异常占比分别为77.4 %、58.1 %、54.8 %，高于对照组的27.4 %、17.7 %、14.5 %（P<0.05）。ALL组的血清ESR、sIL-2R含量高于对照组，IFN-γ含量低于对照组（P<0.05）。在ALL组小儿中，随访到2021年12月1日，平均随访时间29.14±4.28个月，总生存时间为18.29±1.22个月，无事件生存时间为10.48±0.33个月；死亡22例，生存40例，死亡率为35.5 %。Spearman相关分析显示：血清IFN-γ、ESR、sIL-2R含量与CD34+阳性、CD117+阳性、染色体核型异常、总生存时间、无事件生存时间具有相关性（P<0.05）。多因素logistic回归分析显示：IFN-γ、ESR、sIL-2R为影响急性淋巴细胞白血病患儿预后死亡的重要因素（P<0.05）。受试者操作特征曲线（ROC）显示IFN-γ、ESR、sIL-2R预测急性淋巴细胞白血病患儿预后死亡的曲线下面积分别为0.867、0.735、0.796。结论：急性淋巴细胞白血病患儿多伴随有血清IFN-γ的高表达与血清ESR、sIL-2R的低表达，三者都与患儿的免疫表型与染色体核型存在相关性，也是影响患儿预后的重要因素。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate and analysis the correlation between the expression levels of serum Interferon-γ (IFN-γ), erythrocyte sedimentation rate (ESR) and soluble interleukin receptor (sIL-2R) in children with acute lymphoblastic leukemia (ALL). Methods: From February 2017 to October 2020, 62 cases of children with acute lymphoblastic leukemia who were diagnosed and treated in the Department of Hematology of our hospital were selected as the ALL group, and the other 62 cases of healthy children who had physical examination in our hospital during the same period were selected as the control group. The serum IFN-γ, ESR, and sIL-2R levels were used to determine the immunophenotype and chromosome analysis of children in the ALL group, followed up the prognosis of the children and given correlation analysis. Results: The proportions of CD34+, CD117+, and karyotype abnormalities in the ALL group were 77.4 %, 58.1 %, 54.8 %, respectively, which were higher than those of the control group (27.4 %, 17.7 %, 14.5 %)(P<0.05). The levels of serum ESR and sIL-2R in the ALL group were higher than those in the control group, and the levels of IFN-γ were lower than those in the control group(P<0.05). In children in the ALL group, followed-up until December 1, 2021, the average follow-up time were 29.14±4.28 months, the overall survival time were 18.29±1.22 months, and the event-free survival time were 10.48±0.33 months; there were 22 cases were died and 40 cases were survived, the mortality rate were 35.5 %. Spearman correlation analysis showed that serum IFN-γ, ESR, sIL-2R levels were correlated with CD34+ positive, CD117+ positive, abnormal chromosomal karyotype, overall survival time, event-free survival time(P<0.05). Multivariate logistic regression analysis showed that IFN-γ, ESR, sIL-2R were important factors affected the prognosis and death of children with acute lymphoblastic leukemia(P<0.05). Receiver operating characteristic curve(ROC) showed that the area under the curve of IFN-γ, ESR, sIL-2R predicted the prognostic death of children with acute lymphoblastic leukemia were 0.867, 0.735, and 0.796, respectively. Conclusion: Children with acute lymphoblastic leukemia are mostly accompanied by high expression of serum IFN-γ and low expression of serum ESR and sIL-2R. All three of them are related to the immune phenotype and chromosome karyotype of the child, and are also the important factors for the prognosis of children. |
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