| 李一璐,周亚军,任晨曦,姚继国,柯颖颖,何英姿.急性缺血性脑卒中患者血清RBP4、Lp-PLA2及MCP-1水平表达及其与患者病情及预后的关系研究[J].,2022,(11):2086-2090 |
| 急性缺血性脑卒中患者血清RBP4、Lp-PLA2及MCP-1水平表达及其与患者病情及预后的关系研究 |
| Study on the Expression of Serum RBP4, Lp-PLA2 and MCP-1 in Patients with Acute Ischemic Stroke and Their Relationship with Patient Condition and Prognosis |
| 投稿时间：2022-01-06 修订日期：2022-01-31 |
| DOI：10.13241/j.cnki.pmb.2022.11.016 |
| 中文关键词: 急性缺血性脑卒中 RBP4 Lp-PLA2 MCP-1 病情程度 预后 相关性 |
| 英文关键词: Acute ischemic stroke RBP4 Lp-PLA2 MCP-1 Degree of illness Prognosis Relevance |
| 基金项目:上海市自然科学基金项目（07ZR14059）； 上海市第六人民医院院级科学研究基金（院内-2221） |
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| 中文摘要: |
| 摘要 目的：探究急性缺血性脑卒中（AIS）患者血清视黄醇结合蛋白4（RBP4）、脂蛋白磷脂酶A2（Lp-PLA2）及单核细胞趋化蛋白-1（MCP-1）水平表达及其与患者病情及预后的关系。方法：选取2020年6月～2021年12月我院收治的130例初发AIS患者作为研究对象，根据美国国立卫生研究院卒中量表（NIHSS）评分分为轻度组、中度组、重度组，另取同期在我院体检的志愿者45例作为对照组。采用酶联免疫吸附测定（ELLSA）法检测并对比各组血清RBP4、Lp-PLA2、MCP-1水平差异。改良Rankin量表（MRS）评估AIS患者入院14 d预后，比较不同预后患者临床资料差异。采用Pearson相关系数分析血清RBP4、Lp-PLA2、MCP-1水平与NIHSS、MRS评分的相关性。受试者工作特征（ROC）曲线分析血清RBP4、Lp-PLA2、MCP-1对AIS患者预后的预测价值。结果：AIS患者的血清RBP4、Lp-PLA2、MCP-1水平均明显高于对照组，且随着病情程度的加重，血清RBP4、Lp-PLA2、MCP-1水平逐渐升高（P＜0.05）。预后不良组年龄、血清RBP4、Lp-PLA2、MCP-1水平以及NIHSS评分均明显高于预后良好组（P＜0.05）。AIS患者的血清RBP4、Lp-PLA2、MCP-1水平与NIHSS、MRS评分之间均呈正相关（P＜0.05）。血清RBP4、Lp-PLA2、MCP-1三项联合检测预测AIS患者预后的ROC曲线下面积为0.957，明显高于各指标单独检测的0.775、0.799、0.781。结论：AIS患者血清RBP4、Lp-PLA2、MCP-1水平显著升高，升高程度与患者病情及预后密切相关，三项指标联合检测对AIS患者预后具有良好的预测价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression of serum retinol binding protein 4 (RBP4), lipoprotein phospholipase A2 (Lp-PLA2) and monocyte chemoattractant protein-1 (MCP-1) in patients with acute ischemic stroke (AIS) and their relationship with the condition and prognosis of patients. Methods: 130 patients with primary AIS treated in our hospital from June 2020 to December 2021 were selected as the research object. According to the National Institutes of Health Stroke Scale (NIHSS) score, they were divided into mild group, moderate group and severe group, and 45 volunteers who underwent physical examination in our hospital in the same period were taken as the control group. Enzyme linked immunosorbent assay (ELLSA) was used to detect and compare the levels of serum RBP4, Lp-PLA2 and MCP-1 in each group. The improved Rankin Scale (MRS) was used to evaluate the 14 d prognosis of AIS patients, and the clinical data of patients with different prognosis were compared. Pearson correlation coefficient was used to analyze the correlation between serum RBP4, Lp-PLA2 and MCP-1 levels and NIHSS and Mrs scores. The predictive value of serum RBP4, Lp-PLA2 and MCP-1 on the prognosis of AIS patients was analyzed by receiver operating characteristic (ROC) curve. Results: The levels of serum RBP4, Lp-PLA2 and MCP-1 in AIS patients were significantly higher than those in the control group, and the levels of serum RBP4, Lp-PLA2 and MCP-1 increased gradually with the aggravation of the disease(P<0.05). The age, serum RBP4, Lp-PLA2, MCP-1 and NIHSS score in the poor prognosis group were significantly higher than those in the good prognosis group(P< 0.05). The levels of serum RBP4, Lp-PLA2 and MCP-1 in patients with AIS were positively correlated with NIHSS and Mrs scores(P<0.05). The area under the ROC curve of serum RBP4, Lp-PLA2 and MCP-1 in predicting the prognosis of AIS patients was 0.957, which was significantly higher than that of 0.775, 0.799 and 0.781 detected alone. Conclusion: The levels of serum RBP4, Lp-PLA2 and MCP-1 in patients with AIS are significantly increased, and the degree of increase is closely related to the patient's condition and prognosis. The combined detection of the three indexes has a good predictive value for the prognosis of patients with AIS. |
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