| 苑小历,王君宜,胡素琴,张嫣然,高大志.牛黄宁宫片联合阿立哌唑对精神分裂症患者Th1/Th2免疫平衡、神经功能指标和复发的影响[J].,2022,(10):1860-1864 |
| 牛黄宁宫片联合阿立哌唑对精神分裂症患者Th1/Th2免疫平衡、神经功能指标和复发的影响 |
| Effects of Niuhuang Ninggong Tablets Combined with Aripiprazole on Th1/Th2 Immune Balance, Neurological Function Indexes and Recurrence in Patients with Schizophrenia |
| 投稿时间：2021-11-21 修订日期：2021-12-17 |
| DOI：10.13241/j.cnki.pmb.2022.10.013 |
| 中文关键词: 牛黄宁宫片 阿立哌唑 精神分裂症 Th1/Th2免疫平衡 神经功能 复发 |
| 英文关键词: Niuhuang Ninggong tablets Aripiprazole Schizophrenia Th1/Th2 immune balance Neurological function Recurrence |
| 基金项目:江苏省自然科学基金项目（BK20181064） |
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| 中文摘要: |
| 摘要 目的：观察牛黄宁宫片联合阿立哌唑对精神分裂症患者Th1/Th2免疫平衡、神经功能指标和复发的影响。方法：选择2018年2月至2020年7月期间东部战区总医院收治的198例精神分裂症患者，以随机数字表法分为对照组和观察组，各为99例。对照组患者接受阿立哌唑治疗，观察组患者接受牛黄宁宫片联合阿立哌唑治疗，对比两组临床总有效率、Th1/Th2免疫平衡、临床症状、神经功能指标和复发情况，观察两组用药不良反应发生情况。结果：观察组（90.91%）的临床总有效率高于对照组（76.77%），差异有统计学意义（P<0.05）。治疗后观察组外周血肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-23（IL-23）、白细胞介素-17（IL-17）、白细胞介素-1β（IL-1β）水平较对照组更低（P<0.05）。治疗后观察组阳性和阴性症状评定量表（PANSS）各维度评分及总分较对照组更低（P<0.05）。治疗后两组血清神经元特异性烯醇化酶（NSE）、S100β蛋白水平均显著降低，观察组较对照组降低更明显（P<0.05）；治疗后两组脑源性神经营养因子（BDNF）水平升高，且观察组高于对照组（P<0.05）。观察组的复发率低于对照组（P<0.05）。两组不良反应发生率对比无差异（P>0.05）。结论：精神分裂症患者采用牛黄宁宫片联合阿立哌唑治疗后，Th1/Th2免疫平衡和神经功能得到明显恢复，同时还有利于降低复发率，具有良好的临床疗效。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of Niuhuang Ninggong tablets combined with aripiprazole on Th1/Th2 immune balance, neurological function indexes and recurrence in patients with schizophrenia. Methods: 198 patients with schizophrenic who came to General Hospital of Eastern Theater Command for treatment from February 2018 to July 2020 were selected. They were randomly divided into control group and observation group, with 99 cases in each group. The patients in the control group were treated with aripiprazole, and the patients in the observation group were treated with Niuhuang Ninggong tablets combined with aripiprazole. The total clinical effective rate, Th1/Th2 immune balance, clinical symptoms, neurological function indexes and recurrence of the two groups were compared, and the adverse reactions of the two groups were observed. Results: The total clinical effective rate of the observation group （90.91%）was higher than that of the control group（76.77%） (P<0.05). The levels of serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-23 (IL-23), interleukin-17 (IL-17) and interleukin -1β (IL-1β) of the observation group after treatment were significantly lower than those of the control group (P<0.05). After treatment, the scores of all dimensions and total scores of positive and negative symptom rating scale (PANSS) of the observation group were lower than those of the control group (P<0.05). After treatment, the levels of serum neuron specific enolase (NSE) and S100β protein in the two groups were significantly decreased, and the decrease was more obvious in the observation group than the control group (P<0.05). After treatment, the level of brain-derived neurotrophic factor (BDNF) in both groups increased, and the observation group was higher than the control group (P<0.05). The recurrence rate of the observation group was lower than that of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: After treatment with Niuhuang Ninggong tablets combined with aripiprazole, the Th1/Th2 immune balance and neurological function of patients with schizophrenic have been significantly restored. At the same time, it is also conducive to reduce the recurrence rate, and which has good clinical curative effect. |
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