| 宋云熙,王东霞,王 英,杨雅茹,马建新.血清S1P、SFRP1、TIM4、SFRP5与成人支气管哮喘急性发作期患者肺功能、气道炎症和治疗后再次急性复发的关系[J].,2022,(8):1519-1523 |
| 血清S1P、SFRP1、TIM4、SFRP5与成人支气管哮喘急性发作期患者肺功能、气道炎症和治疗后再次急性复发的关系 |
| Relationship between Serum S1P, SFRP1, TIM4 and SFRP5 and Lung Function, Airway Inflammation and Acute Recurrence after Treatment in Adult Patients with Acute Attack Stage of Bronchial Asthma |
| 投稿时间：2021-09-21 修订日期：2021-10-19 |
| DOI：10.13241/j.cnki.pmb.2022.08.025 |
| 中文关键词: 支气管哮喘 急性发作期 S1P SFRP1 TIM4 SFRP5 肺功能 气道炎症 复发 |
| 英文关键词: Bronchial asthma Acute attack stage S1P SFRP1 TIM4 SFRP5 Lung function Airway inflammation Recurrence |
| 基金项目:北京市自然科学基金项目（71621761） |
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| 中文摘要: |
| 摘要 目的：观察血清分泌型卷曲相关蛋白1（SFRP1）、分泌型卷曲相关蛋白5（SFRP5）、1-磷酸鞘氨醇（S1P）、T细胞免疫球蛋白域及黏蛋白域蛋白4（TIM4）与成人支气管哮喘急性发作期患者肺功能、气道炎症和治疗后再次急性复发的关系。方法：选择火箭军特色医学中心2016年7月~2020年8月期间收治的120例成人支气管哮喘患者，其中47例缓解期患者纳为缓解组，73例急性发作期患者纳为发作组。对比发作组、缓解组血清S1P、SFRP1、TIM4、SFRP5水平、肺功能[第1秒用力呼气容积（FEV1）、用力肺活量（FVC）、FEV1/FVC]、气道炎症[血清总免疫球蛋白E（IgE）、痰嗜酸粒细胞、呼出气一氧化氮（FeNO）、血嗜酸粒细胞]，治疗结束后以门诊复查或电话的形式进行随访1年，根据1年内是否再次急性复发分组，分为复发组和未复发组，对比复发组和未复发组的血清S1P、SFRP1、TIM4、SFRP5水平。结果：发作组的S1P、SFRP1、TIM4高于缓解组，SFRP5低于缓解组（P<0.05）。发作组的FEV1、FVC、FEV1/FVC低于缓解组（P<0.05）。发作组的血清总IgE、嗜酸粒细胞、FeNO、血嗜酸粒细胞高于缓解组（P<0.05）。Pearson相关性分析结果显示，S1P、SFRP1、TIM4与FEV1、FVC、FEV1/FVC呈负相关（P<0.05），而与血清总IgE、嗜酸粒细胞、FeNO、血嗜酸粒细胞均呈正相关（P<0.05）。SFRP5与FEV1、FVC、FEV1/FVC呈正相关（P<0.05），而与血清总IgE、嗜酸粒细胞、FeNO、血嗜酸粒细胞均呈负相关（P<0.05）。复发组的S1P、SFRP1、TIM4高于未复发组，SFRP5低于未复发组（P<0.05）。结论：成人支气管哮喘急性发作期患者S1P、SFRP1、TIM4水平异常升高，SFRP5异常降低，且与肺功能、气道炎症、再次急性复发均有一定关系。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the relationship between serum secretory curl associated protein 1 (SFRP1), secretory curl associated protein 5 (SFRP5), sphingosine 1-phosphate (S1P), T cell immunoglobulin domain and mucin domain protein 4 (TIM4) and lung function, airway inflammation and acute recurrence after treatment in adult patients with acute attack stage of bronchial asthma. Methods: 120 patients with bronchial asthma who were treated in Rocket army characteristic medical center from July 2016 to August 2020 were selected, of which 47 patients in remission stage were included in the remission group, 73 patients with acute attack stage were included in the attack group. The serum S1P, SFRP1, TIM4 and SFRP5 levels, lung function[forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), FEV1/FVC], airway inflammation [serum total immunoglobulin E (IgE), sputum eosinophils, exhaled nitric oxide (FeNO), blood eosinophils] in the attack group and remission group were compared. After treatment, the patients were followed up for 1 year in the form of outpatient review or telephone. According to whether there was another acute recurrence within 1 year, they were divided into recurrence group and non recurrence group. The serum S1P, SFRP1, TIM4 and SFRP5 levels in recurrence group and non recurrence group were compared. Results: S1P, SFRP1 and TIM4 in the attack group were higher than those in the remission group, and SFRP5 was lower than that in the remission group (P<0.05). FEV1, FVC and FEV1/FVC in the attack group were lower than those in the remission group (P<0.05). The total serum IgE, eosinophils, FeNO and blood eosinophils in the attack group were higher than those in the remission group(P<0.05). Pearson correlation analysis showed that S1P, SFRP1 and TIM4 were negatively correlated with FEV1, FVC and FEV1/FVC(P<0.05), but positively correlated with serum total IgE, eosinophils, FeNO and blood eosinophils(P<0.05). SFRP5 was positively correlated with FEV1, FVC and FEV1/FVC(P<0.05), but negatively correlated with serum total IgE, eosinophils, FeNO and blood eosinophils(P<0.05). S1P, SFRP1 and TIM4 in the recurrence group were higher than those in the non recurrence group, and SFRP5 was lower than that in the non recurrence group(P<0.05). Conclusion: The S1P, SFRP1 and TIM4 levels are abnormally increased, and SFRP5 is abnormally decreased in adult patients with acute attack stage of bronchial asthma, which is related to lung function, airway inflammation and acute recurrence again. |
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