| 许雪萍,陈小桥,任美玲,王 静,薛 新,俞一芳.小儿肺咳颗粒联合头孢呋辛酯治疗急性支气管炎患儿的临床疗效及对免疫功能和炎症指标的影响[J].,2022,(8):1494-1497 |
| 小儿肺咳颗粒联合头孢呋辛酯治疗急性支气管炎患儿的临床疗效及对免疫功能和炎症指标的影响 |
| Clinical Efficacy of Xiaoer Feike Granule Combined with Cefuroxime Axetil in the Treatment of Children with Acute Bronchitis and its Influence on Immune Function and Inflammatory Indexes |
| 投稿时间：2021-09-05 修订日期：2021-09-28 |
| DOI：10.13241/j.cnki.pmb.2022.08.019 |
| 中文关键词: 小儿肺咳颗粒 头孢呋辛酯 急性支气管炎 儿童 临床疗效 免疫功能 炎症指标 |
| 英文关键词: Xiaoer Feike granule Cefuroxime axetil Acute bronchitis Children Clinical effect Immune function Inflammatory indexes |
| 基金项目:江苏省自然科学基金项目（BK20160166） |
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| 中文摘要: |
| 摘要 目的：探讨小儿肺咳颗粒联合头孢呋辛酯治疗急性支气管炎患儿的临床疗效及对免疫功能和炎症指标的影响。方法：将我院2019年1月到2020年12月期间接收的88例急性支气管炎患儿以信封抽签法的方式分为对照组（头孢呋辛酯治疗）和观察组（小儿肺咳颗粒联合头孢呋辛酯治疗），各44例，两组患儿均治疗10 d。观察两组患儿疗效、临床症状消失时间、免疫功能、炎症因子及不良反应。结果：观察组患儿临床总有效率为90.91%（40/44），高于对照组患儿的70.45%（31/44）（P<0.05）。与对照组相比，观察组的临床症状消失时间（肺部啰音、咳嗽、发热）更短（P<0.05）。治疗10 d后，观察组CD3+、CD4+、CD4+/CD8+高于对照组，CD8+低于对照组（P<0.05）。治疗10 d后，观察组血清白介素-6（IL-6）、超敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）水平低于对照组（P<0.05）。两组不良反应发生率组间对比差异无统计学意义（P>0.05）。结论：急性支气管炎患儿在头孢呋辛酯治疗的基础上给予小儿肺咳颗粒治疗，症状缓解时间缩短，同时还可有效降低血清炎症因子水平，提高患儿免疫力，安全可靠。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical efficacy of Xiaoer Feike granule combined with cefuroxime axetil in the treatment of children with acute bronchitis and its influence on immune function and inflammatory indexes. Methods: 88 cases of children with acute bronchitis in our hospital from January 2019 to December 2020 were randomly divided into control group (treated with cefuroxime axetil) and observation group (treated with Xiaoer Feike granules combined with cefuroxime axetil) by the envelope lottery, with 44 cases in each group. Both groups were treated for 10 days. The curative effect, remission time of clinical symptoms, immune function, inflammatory factors and adverse reactions of the two groups were observed. Results: The clinical total effective rate of the observation group was 90.91%(40/44), which was higher than 70.45%(31/44) of the control group(P<0.05). Compared to the control group, the disappearance time of clinical symptoms (lung rales, cough, fever) of the observation group was shorter (P<0.05). 10 d after treatment, CD3+, CD4+, CD4+/CD8+ of the observation group were higher than those of the control group, and CD8+ was lower than that of the control group(P<0.05). 10d after treatment, the levels of serum interleukin-6 (IL-6), hypersensitive C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α) of the observation group were lower than those of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: On the basis of cefuroxime axetil treatment, the treatment of children with acute bronchitis assisted by Xiaoer Feike granule can shorten the time of symptom relief, effectively reduce the level of serum inflammatory factors, and improve the immunity of children, which is safe and reliable. |
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