| 刘 彤,刘 帆,史淑月,孟银苹,王 鹏.阿卡波糖辅助治疗糖尿病合并甲状腺功能亢进的效果及对T_4 、TSH及脂联素的影响[J].,2022,(7):1371-1374 |
| 阿卡波糖辅助治疗糖尿病合并甲状腺功能亢进的效果及对T_4 、TSH及脂联素的影响 |
| Effect of Acarbose in the Adjuvant Treatment of Diabetes Mellitus Complicated with Hyperthyroidism and Its Effect on T_4, TSH and Adiponectin |
| 投稿时间：2021-08-26 修订日期：2021-09-22 |
| DOI：10.13241/j.cnki.pmb.2022.07.037 |
| 中文关键词: 阿卡波糖 辅助治疗 糖尿病 甲状腺功能亢进 甲状腺素 促甲状腺激素 脂联素 |
| 英文关键词: Acarbose Adjuvant therapy Diabetes Hyperthyroidism Thyroxine Thyroid stimulating hormone Adiponectin |
| 基金项目:河北省科技计划项目（16277135） |
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| 中文摘要: |
| 摘要 目的：探讨阿卡波糖辅助治疗糖尿病合并甲状腺功能亢进的效果及对甲状腺素（T_4 ）、促甲状腺激素（TSH）及脂联素的影响。方法：选择2019年1月-2021年1月在我院接受治疗的105例糖尿病合并甲状腺功能亢进患者，采用随机数表法分为试验组（n=53）和对照组（n=52）。对照组给予甲巯咪唑和甘精胰岛素治疗，试验组在对照组的基础上加用阿卡波糖治疗。比较两组临床疗效、T_4 、TSH及脂联素、空腹血糖（FBG）、餐后2 h血糖（PBG）、胰岛素抵抗（Homa-IR）、胰岛β细胞指数（Homa-β）水平变化情况及不良反应发生情况。结果：治疗后，两组总有效率比较差异显著（P<0.05）；治疗前，试验组和对照组血清T_4 、TSH及脂联素比较无显著差异；治疗后，试验组和对照组血清T_4 及脂联素均随着时间的推移而降低，且试验组均低于对照组，TSH随着时间的推移而升高，且试验组高于对照组，差异显著（P<0.05）；治疗前，试验组和对照组血清FBG、PBG比较无显著差异；治疗后，试验组和对照组血清FBG、PBG均随着时间的推移而降低，且试验组均低于对照组，差异显著（P<0.05）；治疗前，试验组和对照组血清Homa-IR、Homa-β比较无显著差异；治疗后，试验组和对照组血清Homa-IR、Homa-β均随着时间的推移而降低，且试验组均低于对照组，差异显著（P<0.05）；两组不良反应总发生率为3.77%、9.62%，无显著差异（P>0.05）。结论：在糖尿病合并甲状腺功能亢进中应用阿卡波糖辅助治疗疗效显著，可有效改善患者T_4 、TSH及脂联素水平。 |
| 英文摘要: |
| ABSTRACT Objective: To study Effect of acarbose in the adjuvant treatment of diabetes mellitus complicated with hyperthyroidism and its effect on Thyroid hormone (T_4), thyroid stimulating hormone (TSH) and adiponectin. Methods: 105 diabetic patients with hyperthyroidism who received treatment in our hospital from January 2019 to January 2021 were selected and divided into experimental group (n=53) and control group (n=52) by random number table method. Methimazole and insulin glargine were given to the control group, and acarbose was added to the control group. Clinical efficacy, T_4, TSH, adiponectin, fasting blood glucose (FBG), 2 h postprandial blood glucose (PBG), insulin resistance (HOMA-IR), islet β-cell index (HOMA-β) and the incidence of ADR were compared between the two groups. Results: After treatment, the total effective rate between the two groups was significantly different (P<0.05). Before treatment, there were no significant differences in serum T_4, TSH and adiponectin between the experimental group and the control group. After treatment, serum T_4 and adiponectin in experimental group and control group decreased with time, and TSH in experimental group was lower than control group, and the difference was significant (P<0.05). Before treatment, there was no significant difference in serum FBG and PBG between the experimental group and the control group. After treatment, serum FBG and PBG in experimental group and control group decreased with the passage of time, and the difference was significant (P<0.05). Before treatment, there were no significant differences in serum HOMA-IR and HOMA-β between the experimental group and the control group. After treatment, serum HOMA-IR and HOMA-β in both experimental and control groups decreased with time, and the difference was significant (P<0.05). The total incidence of adverse reactions between the two groups was 3.77% and 9.62%, with no significant difference (P>0.05). Conclusion: The adjuvant treatment of acarbose in diabetic patients with hyperthyroidism has a significant effect, which can effectively improve the levels of T_4, TSH and adiponectin in patients. |
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