| 曾 燕,胡玉娟,周 莛,李 黎,朱 岷.单纯性肥胖儿童血清Hcy、visfatin、E-FABP水平与糖脂代谢紊乱和炎症因子的相关性分析[J].,2022,(4):713-717 |
| 单纯性肥胖儿童血清Hcy、visfatin、E-FABP水平与糖脂代谢紊乱和炎症因子的相关性分析 |
| Correlation Analysis of Serum Hcy, Visfatin, E-FABP Levels and Glucose and Lipid Metabolism Disorders and Inflammatory Factors in Children with Simple Obesity |
| 投稿时间：2021-06-05 修订日期：2021-06-28 |
| DOI：10.13241/j.cnki.pmb.2022.04.024 |
| 中文关键词: 单纯性肥胖 同型半胱氨酸 内脂素 上皮型脂肪酸结合蛋白 糖脂代谢 炎症因子 |
| 英文关键词: Simple obesity Homocysteine Visfatin Epithelial fatty acid binding protein Glucose and lipid metabolism Inflammatory factors |
| 基金项目:重庆市医学科研计划项目（2018MSXM142） |
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| 中文摘要: |
| 摘要 目的：研究单纯性肥胖儿童血清同型半胱氨酸（Hcy）、内脂素（visfatin）、上皮型脂肪酸结合蛋白（E-FABP）水平与糖脂代谢紊乱和炎症因子的相关性。方法：将2019年4月～2020年10月于我院就诊的70例单纯性肥胖儿童纳入研究，记作肥胖组。另取同期于我院接受体检的健康儿童70例作为对照组。检测并比较两组血清Hcy、visfatin、E-FABP水平，糖脂代谢紊乱相关指标和炎症因子水平。以Pearson相关性分析明确单纯性肥胖儿童血清Hcy、visfatin、E-FABP水平与糖脂代谢紊乱和炎症因子的关系。结果：肥胖组血清Hcy、visfatin、E-FABP水平均高于对照组（均P＜0.05）。肥胖组空腹血糖（FPG）、空腹胰岛素（FINS）水平及胰岛素抵抗指数（HOMA-IR）均高于对照组（均P＜0.05）。肥胖组总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）水平均高于对照组，而高密度脂蛋白胆固醇（HDL-C）水平低于对照组（均P＜0.05）。肥胖组血清白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）及肿瘤坏死因子-α（TNF-α）水平均高于对照组（均P＜0.05）。经Pearson相关性分析可得：单纯性肥胖儿童血清Hcy、visfatin、E-FABP水平与FPG、FINS、HOMA-IR、TC、TG、LDL-C、IL-1β、IL-6、TNF-α水平均呈正相关，而与HDL-C水平呈负相关（均P＜0.05）。结论：单纯性肥胖儿童血清Hcy、visfatin、E-FABP水平均异常升高，且与其糖脂代谢紊乱及炎症反应密切相关，值得临床重点关注。 |
| 英文摘要: |
| ABSTRACT Objective: To study the correlation between serum homocysteine (Hcy), visfatin (visfatin) and epithelial fatty acid binding protein (E-FABP) levels and glucose and lipid metabolism disorders and inflammatory factors in children with simple obesity. Methods: 70 children with simple obesity who were treated in our hospital from April 2019 to October 2020 were included in the study, and recorded as obesity group. 70 healthy children who underwent physical examination in hospital during the same period were selected as the control group. Serum Hcy, visfatin, E-FABP levels, glucose and lipid metabolism disorders and inflammatory factors were detected and compared between the two groups. Pearson correlation analysis was used to determine the relationship between serum Hcy, visfatin, E-FABP levels and glucose and lipid metabolism disorders and inflammatory factors in children with simple obesity. Results: The serum Hcy, visfatin and E-FABP levels in the obesity group were higher than those in the control group (all P<0.05). The Fasting blood glucose (FPG), fasting insulin (FINS) levels and insulin Resistance Index (HOMA-IR) in the obesity group were higher than those in the control group (all P<0.05). The total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) levels in the obesity group were higher than those in the control group, while the high density lipoprotein cholesterol (HDL-C) level was lower than that in the control group (all P<0.05). The serum interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels in the obesity group were higher than those in the control group (all P<0.05). According to Pearson correlation analysis: the serum Hcy, visfatin and E-FABP levels were positively correlated with the FPG, FINS, HOMA-IR, TC, TG, LDL-C, IL-1β, IL-6 and TNF-α levels, but negatively correlated with the HDL-C level in children with simple obesity (all P<0.05). Conclusion: Serum levels of Hcy, Visfatin and E-FABP are all abnormally elevated in children with simple obesity, which are closely related to glucose and lipid metabolism disorder and inflammatory response, and deserved clinical attention. |
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