| 廖占玲,安国印,吴晶晶,陈润祥,刘 峰.老年不稳定型心绞痛患者血清Irisin、Angptl 2、CTRP1水平与血脂和冠状动脉病变的相关性分析[J].,2022,(3):566-569 |
| 老年不稳定型心绞痛患者血清Irisin、Angptl 2、CTRP1水平与血脂和冠状动脉病变的相关性分析 |
| Correlation Analysis of Serum Irisin, Angptl 2, CTRP1 Levels with Blood Lipid and Coronary Artery Disease in Elderly Patients with Unstable Angina Pectoris |
| 投稿时间：2021-06-24 修订日期：2021-07-20 |
| DOI：10.13241/j.cnki.pmb.2022.03.035 |
| 中文关键词: 不稳定型心绞痛 鸢尾素 血管生成素样蛋白2 C1q肿瘤坏死因子相关蛋白1 血脂 冠状动脉病变 |
| 英文关键词: Unstable angina pectoris Irisin Angiopoietin like protein 2 C1q tumor necrosis factor-related protein 1 Blood lipid Coronary artery disease |
| 基金项目:江苏省卫计委科研项目（H2016674） |
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| 中文摘要: |
| 摘要 目的：探讨老年不稳定型心绞痛（UAP）患者血清鸢尾素（Irisin）、血管生成素样蛋白2（Angptl 2）、C1q肿瘤坏死因子相关蛋白1（CTRP1）水平与血脂和冠状动脉病变的相关性。方法：选择2019年4月至2021年5月期间我院收治的老年UAP患者86例作为观察组，同期在我院体检无冠状动脉病变的志愿者80例作为对照组，比较两组血清Irisin、Angptl 2、CTRP1水平，根据Gensini积分将观察组患者分为轻度病变组28例，中度病变组33例和重度病变组25例，比较各组血清Irisin、Angptl 2、CTRP1及血脂水平，并分析血清Irisin、Angptl 2、CTRP1水平与血脂及Gensini积分的相关性。结果：观察组血清Irisin水平明显低于对照组，Angptl 2、CTRP1水平明显高于对照组（P<0.05）。不同冠状动脉病变程度老年UAP患者血清Irisin、Angptl 2、CTRP1、TC、TG、LDL-C、HDL-C水平比较均有统计学差异（P<0.05），血清Irisin、HDL-C水平随着冠状动脉病变程度的增加而降低，Angptl 2、CTRP1、TC、TG、LDL-C水平则随着冠状动脉病变程度的增加而升高（P<0.05）。Pearson相关性分析显示：老年UAP患者的血清Irisin水平与TC、TG、LDL-C、Gensini积分呈负相关，而与HDL-C呈正相关（P<0.05）；血清Angptl 2、CTRP1水平与TC、TG、LDL-C、Gensini积分呈正相关，而与HDL-C呈负相关（P<0.05）。结论：老年UAP患者血清Irisin水平降低，Angptl 2、CTRP1水平升高，其水平与患者血脂和冠状动脉病变程度密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between serum Irisin, angiopoietin like protein 2(Angptl 2), C1q tumor necrosis factor-related protein 1 (CTRP1) and blood lipid and coronary artery disease in elderly patients with unstable angina pectoris (UAP). Methods: 86 elderly UAP patients treated in our hospital from April 2019 to May 2021 were selected as the observation group, and 80 volunteers who underwent physical examination in our hospital without coronary artery disease in the same period were selected as the control group. The levels of serum Irisin, Angptl 2 and CTRP1 in the two groups were compared. According to Gensini score, the patients in the observation group were divided into 28 cases of mild lesion group, 33 cases of moderate lesion group and 25 cases of severe lesion group. The levels of serum Irisin, Angptl 2 and CTRP1 and blood lipid in each group were compared, and the correlation between the levels of serum Irisin, Angptl 2 and CTRP1 and blood lipid and Gensini score were analyzed. Results: The levels of serum Irisin in the observation group were significantly lower than those in the control group, and the levels of Angptl 2 and CTRP1 in the observation group were significantly higher than those in the control group(P<0.05). There were significant differences in the levels of serum Irisin, Angptl 2, CTRP1, TC, TG, LDL-C and HDL-C in elderly UAP patients with different degrees of coronary artery disease (P<0.05). The levels of serum Irisin and HDL-C decreased with the increase of the degree of coronary artery disease, while the levels of Angptl 2, CTRP1, TC, TG and LDL-C increased with the increase of the degree of coronary artery disease(P<0.05). Pearson correlation analysis showed that the serum Irisin level in elderly patients with UAP was negatively correlated with TC, TG, LDL-C and Gensini score, but positively correlated with HDL-C(P<0.05). The levels of serum Angptl 2 and CTRP1 were positively correlated with TC, TG, LDL-C and Gensini score, but negatively correlated with HDL-C(P<0.05). Conclusion: The level of serum Irisin decreased and the levels of Angptl 2 and CTRP1 increased in elderly patients with UAP, which are closely related to blood lipid and the degree of coronary artery disease. |
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