| 潘慧莹,石先明,齐 玥,孟玉娟,朱 静.加味苦参汤联合紫归解毒膏对肛瘘术后创面愈合、肛肠动力学及血清TNF-α、IL-6、bFGF、TGF-β1水平的影响[J].,2022,(2):388-391 |
| 加味苦参汤联合紫归解毒膏对肛瘘术后创面愈合、肛肠动力学及血清TNF-α、IL-6、bFGF、TGF-β1水平的影响 |
| Effect of Jiawei Kushen Decoction Combined with Zigui Jiedu Ointment on Wound Healing, Anorectal Dynamics and Serum TNF-α, IL-6, bFGF and TGF-β1 Levels after Anal Fistula Operation |
| 投稿时间：2021-05-11 修订日期：2021-06-06 |
| DOI：10.13241/j.cnki.pmb.2022.02.037 |
| 中文关键词: 加味苦参汤 紫归解毒膏 肛瘘术后 创面愈合 肛肠动力学 TNF-α IL-6 TGF-β1 bFGF |
| 英文关键词: iawei Kushen Decoction Zigui Jiedu ointment After anal fistula operation Wound healing Anorectal dynamics TNF-α IL-6 TGF-β1 bFGF |
| 基金项目:辽宁省博士启动基金项目（20170520316） |
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| 中文摘要: |
| 摘要 目的：探讨加味苦参汤联合紫归解毒膏对肛瘘术后创面愈合、肛肠动力学及血清肿瘤坏死因子-α（TNF-α）、白介素-6（IL-6）、转移生长因子-β1（TGF-β1）、碱性成纤维细胞生长因子（bFGF）水平的影响。方法：选取2015年6月~2019年6月期间我院收治的肛瘘术后患者80例，以随机数字表法将患者分为研究组（n=40，加味苦参汤联合紫归解毒膏治疗）和对照组（n=40，紫归解毒膏治疗），均治疗14 d。比较两组患者疗效、创面愈合情况、肛肠动力学及相关血清细胞因子水平，记录两组患者不良反应发生情况。结果：研究组治疗14 d后的临床总有效率为87.50%（35/40），显著高于对照组的65.00%（26/40），差异有统计学意义（P<0.05）。与对照组相比，研究组创面出血评分、创面水肿评分更低，创面愈合时间更短（P<0.05）。两组患者治疗14 d后直肠静息压（RRP）、肛管静息压（ARP）均下降，但研究组高于对照组（P<0.05）。两组治疗14 d后血清TNF-α、IL-6水平下降，且研究组低于对照组（P<0.05）；两组治疗14 d后血清TGF-β1、bFGF水平升高，且研究组高于对照组（P<0.05）。两组不良反应发生率比较无差异（P>0.05）。结论：加味苦参汤联合紫归解毒膏治疗肛瘘术后患者，可促进创面尽快愈合，改善患者肛肠动力学及血清TNF-α、IL-6、TGF-β1、bFGF水平，且不增加不良反应发生率，疗效较好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Jiawei Kushen decoction combined with Zigui Jiedu ointment on wound healing, anorectal dynamics, serum Tumor necrosis factor-α (TNF-α), interleukin-6(IL-6), transfer growth factor-1(TGF-β1), basic fibroblast growth factor (bFGF)levels after anal fistula operation. Methods: 80 patients who underwent anal fistula operation in our hospital from June 2015 to June 2019 were selected, they were divided into control group(n=40) and study group(n=40) according to the method of random number table. Patients in the control group were treated with Zigui Jiedu cream. The study group was treated with modified Kushen Decoction on the basis of the control group. The curative effect, wound healing, anorectal dynamics and related blood of the two groups were compared The adverse reactions of the two groups were recorded. Results: The total clinical effective rate of the study group was 87.5%(35/40), which was significantly higher than 65.00%(26/40) of the control group(P<0.05). The wound healing time of the study group was shorter than that of the control group, and the scores of bleeding and edema were lower than that of the control group (P<0.05). The rectal resting pressure(RRP), anal resting pressure (ARP) of the two groups decreased after 14 days treatment, but the study group was higher than the control group(P<0.05). After 14 days of treatment, TNF-α and IL-6 decreased in the two groups, which was lower in the study group than in the control group(P<0.05); after 14 days of treatment, TGF-β1 and bFGF increased in the two groups, which was higher in the study group than in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Jiawei Kushen decoction combined with Zigui Jiedu ointment can promote wound healing as soon as possible, improve anorectal dynamics and serum TNF-α, IL-6, TGF-β1, bFGF levels, and do not increase the incidence of adverse reactions, with definite effect. |
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