| 顾婷婷,齐保龙,苑仁祥,赵 琴,孙静茹.稳定期慢性阻塞性肺疾病患者营养不良与甲状腺激素、肺功能及血清IL-6、IL-18的关系研究[J].,2022,(2):347-351 |
| 稳定期慢性阻塞性肺疾病患者营养不良与甲状腺激素、肺功能及血清IL-6、IL-18的关系研究 |
| Relationship Study between Malnutrition and Thyroid Hormone, Lung Function, Serum IL-6, IL-18 in Patients with Stable Chronic Obstructive Pulmonary Disease |
| 投稿时间：2021-05-23 修订日期：2021-06-17 |
| DOI：10.13241/j.cnki.pmb.2022.02.029 |
| 中文关键词: 慢性阻塞性肺疾病 营养不良 甲状腺激素 肺功能 白细胞介素-6、白细胞介素-18 |
| 英文关键词: Chronic obstructive pulmonary disease Malnutrition Thyroid hormone Lung function Interleukin-6 Interleukin-18 |
| 基金项目:安徽省科技厅科技攻关项目（8010302719） |
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| 中文摘要: |
| 摘要 目的：观察稳定期慢性阻塞性肺疾病（COPD）患者营养不良与甲状腺激素、肺功能及血清白细胞介素（IL）-6、IL-18的关系。方法：选择2019年1月~2020年12月我院收治的稳定期COPD患者76例作为研究对象。根据患者的微型营养评定（MNA）评分将其分为营养不良组(n=31)和非营养不良组(n=45)，比较两组患者的人口学资料、疾病相关因素，甲状腺激素[三碘甲状腺原氨酸（T3）、甲状腺激素（T4）、促甲状腺激素（TSH）]水平，肺功能[第1秒用力呼气量占预测值百分比（FEV1%pred）、第1秒用力呼气量与用力肺活量比值（FEV1/FVC）]，血清IL-6、IL-18水平。分析MNA评分与甲状腺激素水平、肺功能及血清IL-6、IL-18水平的相关性。分析患者发生营养不良的危险因素。结果：营养不良组年龄高于非营养不良组（P＜0.05）。营养不良组T3、T4、TSH、FEV1%pred、FEV1/FVC显著低于非营养不良组，血清IL-6、IL-18水平显著高于非营养不良组（P＜0.05）。稳定期COPD患者的MNA评分与T3、T4、TSH、FEV1%pred、FEV1/FVC呈正相关，与IL-6、IL-18呈负相关（P＜0.05）。多因素Logistic回归分析显示，年龄＞60岁、T3≤1.60 nmol/L、T4≤73.00 nmol/L、TSH≤1.50 nmol/L、FEV1%pred≤60.00 %、FEV1/FVC≤0.54、IL-6≥8.00 pg/mL、IL-18≥47. 00 pg/mL是稳定期COPD患者营养不良的危险因素（P＜0.05）。结论：稳定期COPD患者营养不良受多种因素影响，临床应针对相关因素给予有效干预，降低此类患者营养不良风险。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the relationship between malnutrition and thyroid hormone, lung function, serum interleukin (IL)-6 and IL-18 in patients with stable chronic obstructive pulmonary disease (COPD). Methods: 76 stable COPD patients from January 2019 to December 2020 in our hospital were selected as research objects. According to the Micronutrient assessment (MNA) score, the patients were divided into malnutrition group (n=31) and non malnutrition group (n=45). The demographic data, disease-related factors, thyroid hormones [triiodothyronine (T3), thyroid hormone (T4), thyroid stimulating hormone (TSH)], Lung function [Percentage of predicted forced expiratory volume in 1 second (FEV1%pred), ratio of forced expiratory volume in 1 second to forced vital capacity (FEV1/FVC)], serum IL-6 and IL-18 levels were compared between the two groups. The correlation between MNA score and thyroid hormone level, lung function, serum IL-6, IL-18 level was analyzed. The risk factors of malnutrition were analyzed. Results: The age of the malnutrition group were higher than those of the non malnutrition group(P<0.05). The levels of T3, T4, TSH, FEV1%pred and FEV1/FVC in malnutrition group were significantly lower than those in non malnutrition group, and the levels of serum IL-6 and IL-18 were significantly higher than those in non malnutrition group(P<0.05). MNA score of stable COPD patients was positively correlated with T3, T4, TSH, FEV1%pred, FEV1/FVC, and negatively correlated with IL-6 and IL-18(P<0.05). Multivariate Logistic regression analysis showed that age > 60 years, T3 ≤1.60 nmol / L, T4 ≤73.00 nmol/L, TSH ≤1.50 nmol/L, FEV1%pred ≤60.00%, FEV1/FVC ≤0.54, IL-6 ≥8.00 pg/mL, IL-18 ≥47.00 pg/mL were risk factors for malnutrition in stable COPD patients(P<0.05). Conclusion: Malnutrition in stable COPD patients is affected by a variety of factors, and effective clinical intervention should be given according to relevant factors to reduce the risk of malnutrition in such patients. |
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