| 刘鸿儒,李 俊,陆 明,郭秀岚,李明涛.疏肝健脾针法对肝郁脾虚证腹泻型肠易激综合征患者肠道菌群和血清5-HT、NPY、CGRP的影响[J].,2022,(2):259-263 |
| 疏肝健脾针法对肝郁脾虚证腹泻型肠易激综合征患者肠道菌群和血清5-HT、NPY、CGRP的影响 |
| Effects of Shugan Jianpi Acupuncture on Intestinal Flora and Serum 5-HT, NPY and CGRP in Patients with Diarrhea Irritable Bowel Syndrome with Liver Depression and Spleen Deficiency Syndrome |
| 投稿时间：2021-08-24 修订日期：2021-09-19 |
| DOI：10.13241/j.cnki.pmb.2022.02.011 |
| 中文关键词: 疏肝健脾针法 肝郁脾虚证 腹泻型肠易激综合征 临床疗效 肠道菌群 |
| 英文关键词: Shugan Jianpi acupuncture Liver depression and spleen deficiency syndrome Diarrhea irritable bowel syndrome Clinical efficacy Intestinal flora |
| 基金项目:天津市卫生和计划生育委员会基金项目(2015022) |
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| 摘要 目的：观察疏肝健脾针法治疗肝郁脾虚证腹泻型肠易激综合征（IBS-D）的临床疗效及对肠道菌群和血清5-羟色胺（5-HT）、降钙素基因相关肽（CGRP）、神经肽Y（NPY）的影响。方法：96例肝郁脾虚证IBS-D患者均来自天津市人民医院2018年5月~2021年2月期间收治的门诊或住院患者。根据双色球法将患者分为对照组和研究组，各为48例，对照组接受西医治疗，研究组在对照组基础上结合疏肝健脾针法治疗，对比两组疗效、中医证候积分、肠道菌群和血清5-HT、NPY、CGRP水平变化。结果：研究组的临床总有效率明显高于对照组（P<0.05）。疗程结束后，研究组大便稀溏、少腹胀痛、食后腹胀、食欲减退、精神疲乏、口苦口黏、四肢无力、烦躁易急、畏寒怕冷症状积分均低于对照组（P<0.05）。疗程结束后，研究组血清5-HT、NPY、CGRP水平均低于对照组（P<0.05）。疗程结束后，研究组双歧杆菌、双歧杆菌/大肠杆菌比值、乳酸杆菌数量均高于对照组，而大肠杆菌数量低于对照组（P<0.05）。结论：疏肝健脾针法治疗肝郁脾虚证IBS-D患者，可有效促进症状改善，调节肠道菌群，降低血清5-HT、NPY、CGRP水平，临床疗效显著。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the clinical efficacy of Shugan Jianpi acupuncture in the treatment of diarrhea irritable bowel syndrome (IBS-D) with liver depression and spleen deficiency syndrome and its effects on intestinal flora, serum serotonin (5-HT), calcitonin gene-related peptide (CGRP) and neuropeptide Y (NPY). Methods: 96 IBS-D patients with liver depression and spleen deficiency syndrome were all outpatients or inpatients who were treated in Tianjin People's Hospital from May 2018 to February 2021 were selected. According to the two-color ball method, the patients were divided into control group and study group, with 48 cases in each group. The control group was treated with western medicine. The study group was treated with Shugan Jianpi acupuncture on the basis of the control group. The curative effect, TCM syndrome score, intestinal flora and the changes of serum 5-HT, NPY and CGRP were compared between the two groups. Results: The total clinical effective rate of the study group was significantly higher than that of the control group (P<0.05). After the course of treatment, the symptom scores of loose stool, less abdominal pain, abdominal distension after eating, anorexia, mental fatigue, bitter mouth and sticky mouth, limb weakness, irritability and irritability, fear of cold and fear of cold in the study group were lower than those in the control group(P<0.05). After the course of treatment, the levels of serum 5-HT, NPY and CGRP in the study group were lower than those in the control group(P<0.05). After treatment, the number of bifidobacteria, bifidobacteria/Escherichia coli ratio and Lactobacillus in the study group were higher than those in the control group, while the number of Escherichia coli was lower than that in the control group(P<0.05). Conclusion: Shugan Jianpi acupuncture in the treatment of IBS-D patients with liver depression and spleen deficiency can effectively promote the improvement of symptoms, regulate intestinal flora and reduce the levels of serum 5-HT, NPY and CGRP. |
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