| 高 琳,王 丽,谭 焰,李 倩,解卫平.维生素D联合肺泡灌洗对机械通气重症肺炎患者血清CHE、PA的影响[J].,2021,(24):4681-4685 |
| 维生素D联合肺泡灌洗对机械通气重症肺炎患者血清CHE、PA的影响 |
| Effect of Vitamin D Combined with Alveolar Lavage on Serum CHE and PA of Patients with Severe Pneumonia in Mechanical Ventilation |
| 投稿时间：2021-05-06 修订日期：2021-05-30 |
| DOI：10.13241/j.cnki.pmb.2021.24.016 |
| 中文关键词: 维生素D 肺泡灌洗 机械通气 重症肺炎 胆碱酯酶 前白蛋白 |
| 英文关键词: Vitamin D Alveolar lavage Mechanical ventilation Severe pneumonia Cholinesterase Prealbumin |
| 基金项目:国家自然科学基金青年项目（81903089）；南京医科大学科技发展基金—— 一般项目（NMUB2019165） |
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| 中文摘要: |
| 摘要 目的：探讨维生素D联合肺泡灌洗对机械通气重症肺炎患者血清胆碱酯酶（Cholinesterase，CHE）、前白蛋白（Prealbumin，PA）的影响。方法：2018年8月到2021年2月选择在本院重症监护病房（Intensive Care Unit，ICU）诊治的重症肺炎患者78例作为研究对象，根据随机信封1:1抽签原则将患者分为联合组与对照组各39例。对照组给予肺泡灌洗治疗，联合组在对照组治疗基础上给予外源性维生素D治疗，两组均给予机械通气治疗，且治疗观察2周。结果：治疗后联合组的总有效率为97.4 %，高于对照组的84.6 %（P<0.05）。所有患者在治疗期间都无出现窒息、气胸、气道痉挛、心律失常等不良反应，联合组的入住ICU时间与ICU费用少于对照组（P<0.05）。两组治疗后的第1秒FEV1、PaO2高于治疗前（P<0.05），联合组高于对照组（P<0.05）。两组治疗后的血清CHE、PA水平高于治疗前（P<0.05），联合组高于对照组（P<0.05）。结论：维生素D联合肺泡灌洗在机械通气重症肺炎患者的应用能抑制血清CHE、PA的表达，改善血气状况与肺功能，提高治疗效果，缩短入住ICU时间与降低ICU费用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of vitamin D combined with alveolar lavage on serum cholinesterase (CHE) and prealbumin (PA) in patients with severe pneumonia from mechanical ventilation. Methods: From August 2018 to February 2021, 78 cases of patients with severe pneumonia diagnosed and treated in the Intensive Care Unit (ICU) of our hospital were selected as the research objects, and the patients were divided into the combination group and control groups of 39 cases in each groups accorded to the random envelope 1:1 lottery principle. The control group were given alveolar lavage treatment, the combination group were given exogenous vitamin D treatment on the basis of the control group's treatment, both groups were given mechanical ventilation treatment, and the two groups were treated for 2 weeks. Results: After treatment, the total effective rates of the combination group were 97.4%, which were higher than 84.6% of the control group (P<0.05). During the treatment, all patients had no adverse reactions such as asphyxia, pneumothorax, airway spasm, arrhythmia, and the combination group's ICU admission time and ICU cost were less than those of the control group (P<0.05). The orced expiratory volume in one second (FEV1) and PaO2 in the two groups were higher than before treatment (P<0.05), and the combination group were higher than the control group(P<0.05). The serum CHE and PA levels of the two groups after treatment were higher than those before treatment(P<0.05), and the combination group were higher than the control group(P<0.05). Conclusion: The application of vitamin D combined with alveolar lavage in patients with severe pneumonia on mechanical ventilation can inhibit the expression of serum CHE and PA, improve blood gas status and pulmonary function, improve the treatment effect, shorten the time of admission to the ICU and reduce the cost of ICU. |
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