| 席 瑛,邵雪妮,王 璐,郭伟楠,李彩霞.中药药浴联合卤米松乳膏对银屑病患者角质层神经酰胺及屏障功能的影响[J].,2021,(23):4593-4597 |
| 中药药浴联合卤米松乳膏对银屑病患者角质层神经酰胺及屏障功能的影响 |
| The Effect of Traditional Chinese Medicinal Bath Combined with Halometasone Cream on Ceramide and Barrier Function of Stratum Corneum in Patients with Psoriasis |
| 投稿时间：2021-04-27 修订日期：2021-05-23 |
| DOI：10.13241/j.cnki.pmb.2021.23.041 |
| 中文关键词: 银屑病 中药 卤米松乳膏 角质层 神经酰胺 屏障 |
| 英文关键词: Psoriasis Traditional Chinese medicine Halometasone cream Stratum corneum Ceramide Barrier |
| 基金项目:陕西省自然科学基础研究计划项目（2020JM-320） |
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| 中文摘要: |
| 摘要 目的：研究中药药浴联合卤米松乳膏对银屑病患者角质层神经酰胺及屏障功能的影响。方法：本研究招募2020年3月~2021年5月在我院皮肤门诊科就诊的80例银屑病患者，所有患者经临床病理确诊寻常型银屑病。其中男性患者52例，女性患者28例，患者年龄23~72岁，平均年龄48.29±6.33岁。实验分为两组：对照组（常规药物治疗）和观察组（中药药浴联合卤米松乳膏进行治疗）。观察患者病情康复情况，据PASI评分比较银屑病患者的总体严重程度，通过DLQI评分和VAS评估患者皮肤干燥和脱屑，通过电容检测和经表皮失水评估银屑病患者皮肤的水化程度和屏障功能，通过反相-液相色谱-质谱法分析患者角质层细胞中神经酰胺Cer和Cer（[NP]/[NS]）。通过蛋白印迹检测患者病变区域VEGFR-1和VEGFR-2的蛋白表达。结果：（1）根据PASI比较银屑病患者的总体严重程度，治疗前3周，两组患者PASI评分比较无差别（P>0.05），第5周、8周和12周观察组较对照组的PASI评分降低（P<0.05）。（2）观察组较对照组DLQI和VAS评分降低（P<0.05）。（3）观察组较对照组病患者病变皮肤的电容增大，经表皮水分降低（P<0.05）。（4）观察组组较对照组Cer含量和Cer（[NP]/[NS]）升高（P<0.05）。（5）观察组较对照组VEGFR-1和VEGFR-2的蛋白表达降低。结论：中药药浴联合卤米松乳膏通过提高银屑病患者Cer的含量和Cer（[NP]/[NS]比率，维持角质层细胞的屏障功能，从而改善患者的皮肤干燥和瘙痒，角质层神经酰胺及屏障功能。 |
| 英文摘要: |
| ABSTRACT Objective: To study the effect of traditional Chinese medicine bath combined with halometasone cream on ceramide and barrier function of stratum corneum in patients with psoriasis. Methods: This study recruited 80 patients with psoriasis who were treated in the Dermatology Clinic of our hospital from March 2020 to May 2021. All patients were diagnosed with psoriasis vulgaris through clinicopathology. Among them, 52 were male patients and 28 were female patients. The patients were 23-72 years old, with an average age of 48.29±6.33 years old. The experiment was divided into two groups: the control group (conventional drug treatment) and the observation group (Chinese medicinal bath combined with Metone cream for treatment). Observe the recovery of the two groups of patients. Compare the overall severity of psoriasis patients according to PASI. The dryness and desquamation of the skin of patients were evaluated by DLQI score and VAS. The hydration degree and barrier function of the skin of patients with psoriasis were evaluated by capacitance detection and transepidermal water loss. Analyze Cer and Cer ([NP]/[NS]) in the stratum corneum cells of patients by reversed-phase-liquid chromatography-mass spectrometry. The protein expression of VEGFR-1 and VEGFR-2 in the diseased area of the patient was detected by Western blot. Results: (1) 3 weeks before treatment, there was no difference in PASI scores between the two groups (P>0.05), and the PASI scores of the observation group at the 5th, 8th and 12th week were lower than those of the control group (P<0.05). (2) The DLQI and VAS scores of the observation group were lower than those of the control group (P<0.05). (3) Compared with the control group, the capacitance of the diseased skin of the observation group increased, and the transepidermal water level decreased (P<0.05). (4) The Cer content and Cer ([NP]/[NS]) of the observation group were higher than those of the control group (P<0.05). (5) The protein expression of VEGFR-1 and VEGFR-2 in the observation group was lower than that in the control group. Conclusion: Chinese medicinal bath combined with halometasone cream can improve the content of Cer and the ratio of Cer([NP]/[NS] in patients with psoriasis to maintain the barrier function of stratum corneum cells, thereby improving dry skin and itching of patients. Ceramide and barrier function. |
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